Implications of Physical Education Activities as Reinforcement in Learning Multiplication Tables

Higher Educatio

Quickening the pulse: Fractal tempos in continental arc magmatism

The magmatic history of a continental arc can be characterized as punctuated equilibrium, whereby long periods of low-level activity are interrupted periodically by short bursts of high-volume magmatism (“flare-ups”). Geochronological records, most notably from zircon, reveal episodicity in volcanism, pluton formation, and detrital sedimentation in, and associated with, arc segments and volcano-plutonic suites. Distinct tempos can be recognized at all resolvable spatial and temporal scales and are broadly fractal, with each scale reflecting the timescale of processes occurring at different levels in the arc crust. The tempos of continental arc magmatism thus reflect modulation of the mantle-power input as it is progressively filtered through the continental crust

Submarine Volcanism of the Cabo de Gata Magmatic Arc in the Betic-Rif Orogen, SE Spain: Processes and Products

Volcanic eruptions in subaqueous settings have been traditionally characterized by the study of ancient deposits and, more recently, by indirect observation of the sea floor with different geophysical means. Subaqueous volcanism is largely governed by the physical properties of water and the way water interacts with magma. Among the characteristic products of subaqueous volcanism are hyaloclastite breccias of dense clasts and of pumiceous clasts produced by the quench fragmentation of hot magma in effusive eruptions. Pumice breccias driven by fragmentation of magma in explosive eruptions are not infrequent. The Miocene volcanic zone of Cabo de Gata in southeastern Spain provides excellent exposures where to test the current understanding on subaqueous volcanism. In particular, submarine lavas with a coherent core and an outer carapace of vesicular hyaloclastite together with pumice breccias and crystal tuffs of the El Barronal Formation provide clues to understand transient conditions during explosive and effusive eruptions. Debris avalanches deposits are rather common in Cabo de Gata, such as those of the Los Frailes Formation and the Cerro Estorvillas Formation, and help to understand the instability processes of submarine volcanic edifices and the resultant mass flows. Interbedding of volcanic rocks with shallow water sedimentary rocks allows inferring water depth conditions for volcanism and the subsidence history of the volcano-sedimentary basin

Facies architecture, emplacement mechanisms and eruption style of the submarine andesite El Barronal complex, Cabo de Gata, SE Spain

El Barronal complex consists of a succession of andesite lavas and andesite volcaniclastic facies interbedded with carbonate and siliciclastic sedimentary rocks. Carbonate and siliciclastic rocks were deposited in a shallow-marine environment during periods of volcanic quiescence. Lavas consist of an inner coherent core grading outward into hyaloclastite breccia made of dense clasts that in turn grade into hyaloclastite breccia made of vesicular clasts, in massive to layered zones. Volcaniclastic facies contain clasts produced during explosive eruptions and reworked clasts from sources above wave base. Volcaniclastic facies were deposited from cold granular flows with different grain size populations. Stratigraphy and facies architecture at El Barronal suggest that a succession of several discrete eruptive events occurred with a similar cyclic pattern made of an initial explosive phase followed by effusive emplacement of lavas, in turn followed by a period of quiescence of volcanic activity. Hyaloclastic fragmentation of magma took place in the final stages of lava emplacement, allowing only for local disorganization of the jigsaw-fit texture. © 2013 Elsevier B.V.This research has been funded by projects CGL2005-03511/BTE and HI2006-0073Peer Reviewe

Chemical abrasion applied to LA-ICP-MS U-Pb zircon geochronology

Zircon (ZrSiO4) is the most commonly used mineral in U-Pb geochronology. Although it has proven to be a robust chronometer, it can suffer from Pb-loss or elevated common Pb, both of which impede precision and accuracy of age determinations. Chemical abrasion of zircon involves thermal annealing followed by relatively low temperature partial dissolution in HF acid. It was specifically developed to minimize or eliminate the effects of Pb-loss prior to analysis using Thermal Ionization Mass Spectrometry (TIMS). Here we test the application of chemical abrasion to Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) by analyzing zircons from both untreated and chemically abraded samples. Rates of ablation for high alpha-dose non-treated zircons are up to 25% faster than chemically abraded equivalents. Ablation of 91500 zircon reference material demonstrates a ca. 3% greater down-hole fractionation of Pb-206/U-238 for non-treated zircons. These disparities necessitate using chemical abrasion for both primary reference material and unknowns to avoid applying an incorrect laser induced fractionation correction. All treated samples display a marked increase in the degree of concordance and/or lowering of common Pb, thereby illustrating the effectiveness of chemical abrasion to LA-ICP-MS U-Pb zircon geochronology

Geochronology, geochemistry and geodynamics of the Cabo de Gata volcanic zone, Southeastern Spain

© 2014 Societa Geologica Italiana, Roma. New 40Ar/39Ar ages and major and trace element geochemistry of the middle-late Miocene Cabo de Gata volcanic complex, southeast Spain, indicate that the volcanic activity of the Cabo de Gata volcanic zone developed over a short period through several pulses of geochemically and isotopically different parental magmas. The oldest volcanic rocks exposed in the Cabo de Gata volcanic zone are the shoshonite and high-K calc-Alkaline rocks of Bujo group, which cry - stallised from a parental magma transitional from calc-Alkaline to alkaline potassic generated through large degrees of partial melting, and then affected by a minor contribution from metasomatised veins and a larger one from the surrounding mantle wedge, in comparison to ultrapotassic melts. Subsequent partial melting of the mantle source produced typical calc-Alkaline parental magmas belonging to the Rodalquilar and Agua Amarga groups. Sr-Nd-Pb isotope and incompatible trace element distributions of Cabo de Gata rocks are in agreement with a mantle-wedge source affected by a two-fold metasomatism. The data suggested that mild potassic to sub-Alkaline subduction-related parental magmas (i.e., high-K calc-Alkaline and calc-Alkaline) were generated in the Cabo de Gata sector within a mantle wedge metasomatised by a fluid-dominated agent. In contrast, the enrichment in K2O of shoshonitic to ultrapotassic magmas was achieved through recycling of subducted sediments through melts that enriched the mantle wedge in K and related elements. Such a scenario can be easily reconciled with a geodynamic setting at the edge of a destructive plate margin with the subducted slab responsible for the recycling of sediments within the mantle wedge.Geochemical, petrographic and analytical work were supported by the Italian MIUR through Cofin_2004 (grants #2004040502_001 and 2004040502_002), Cofin_2008 (grants #2008HMHYFP_002 and 2008HMHYFP_004) and Cofin_2010-2011 (grants #2010TT22SC_001, 2010TT22SC_005 and 2010TT22SC_006; 2010TT22SC_003) projects, to Sandro Conticelli and Massimo Mattei, respectively. Further financial support for geochronological analyses was provided by Spanish projects CGL2009-06968-E, CGL2005-03511/BTE and HI2006-0073 to Carles C. Soriano.Peer Reviewe

Geologic map, volcanic stratigraphy and structure of the Cabo de Gata volcanic zone, Betic-Rif orogen, SE Spain

The geologic map of the Neogene Cabo de Gata volcanic zone is presented together with a comprehensive volcanic stratigraphy and structure based on logging, correlation and mapping. Volcanic rocks are interbedded with sedimentary rocks throughout the Cabo de Gata volcanic zone. The volcano-sedimentary succession of Cabo de Gata has been divided into formations according to lithology, age, composition and stratigraphic position. The contacts between sedimentary units and volcanic units and between formations are unconformities. Sedimentary units were deposited during periods of volcanic repose. The depositional environment of volcanism in Cabo de Gata is characterized as shallow-water submarine to emergent based on lithofacies of volcanic rocks and on fossil content and sedimentary structures of sedimentary rocks. The eruptive style in Cabo de Gata is dominantly effusive, although small-volume explosive eruptions due to magma-water interaction processes and to explosions of lava flow and domes complexes occurred.Peer Reviewe

The role of “omics” technologies for livestock sustainability

Un exitoso programa de seguridad alimentaria de una población en crecimiento necesita una producción más eficiente y sostenible del ganado para asegurar la disponibilidad de alto valor nutritivo, y también la salud y el bienestar de los seres humanos y los animales, y protección del medio ambiente. Innovaciones y avances tecnológicos vendrán de la investigación básica y fundamental. En particular, la integración de la genómica con otros campos de investigación '' OMIC '' y métodos computacionales, posiblemente, facilitar la comprensión de los mecanismos biológicos que son responsables de los atributos físicos o fenotipos de animales. Ejemplos OMIC de diversos métodos y sus aplicaciones se describen para demostrar los avances recientes y cómo estos métodos se pueden aplicar a la producción animal. Los avances en la investigación en genómica y otros campos ómicas se pueden utilizar para aumentar la productividad de los animales, satisfacer la creciente demanda de alimentos de origen animal, aumentar la disponibilidad de nutrientes de alta calidad, garantizar la seguridad alimentaria, mitigar los efectos de la variabilidad climático, y el resultado en nuevas tecnologías que favorezcan un mejor seguridad de los alimentos en todo el mundo.A successful program of food security for a growing population requires the production of livestock in the most efficient and sustainable manner possible to ensure the availability of nutritious foods, the overall health and well-being of humans and animals, and the protection of the environment. Innovative and technological advancements that enhance all aspects of food production will arise from basic, fundamental research. Notably, the integration of genomics with other “’omics” research fields and computational methods will continue to lead to a better understanding of biological mechanisms that are responsible for physical attributes, or phenotypes. Examples of several ‘omics methods and their applications are described to demonstrate recent advances and how these methods can be applied to livestock. Research breakthroughs in genomics and other ‘omics fields can be used to enhance the productivity of food animals, meet the increasing demand for animal-sourced foods, enhance high-quality nutrient availability, ensure nutrient safety, mitigate the effects of climate variability, and result in new technologies that provide continuous improvement in food security worldwide.Um programa bem-sucedido de segurança alimentar para uma população em crescimento necessita de uma produção animal mais eficiente e sustentável para assegurar a disponibilidade de alimentos de alto valor nutricional, e também a saúde e o bem-estar dos humanos e dos animais, e a proteção do ambiente. Inovações e avanços tecnológicos surgirão da pesquisa básica e fundamental. Em especial, a integração da genômica com outros campos de pesquisa ''ômicos '' e com métodos computacionais possivelmente facilitará o entendimento dos mecanismos biológicos que são responsáveis por atributos físicos ou fenótipos dos animais. Exemplos de vários métodos ômicos e suas aplicações são descritos para demonstrar os avanços recentes e como esses métodos podem ser aplicados para produção animal. Os avanços na pesquisa em genômica e em outros campos ômicos podem ser usados para aumentar a produtividade de animais, atender à crescente demanda por alimentos de origem animal, aumentar a disponibilidade de nutrientes de alta qualidade, garantir a segurança nutricional, mitigar os efeitos da variabilidade climática, e resultar em novas tecnologias que favorecem a melhora a segurança alimentar em todo o mundo

Bone Microenvironment Specific Roles of ITAM Adapter Signaling during Bone Remodeling Induced by Acute Estrogen-Deficiency

Immunoreceptor tyrosine-based activation motif (ITAM) signaling mediated by DAP12 or Fcε receptor Iγ chain (FcRγ) have been shown to be critical for osteoclast differentiation and maturation under normal physiological conditions. Their function in pathological conditions is unknown. We studied the role of ITAM signaling during rapid bone remodeling induced by acute estrogen-deficiency in wild-type (WT), DAP12-deficient (DAP12-/-), FcRγ-deficient (FcRγ-/-) and double-deficient (DAP12-/-FcRγ-/-) mice. Six weeks after ovariectomy (OVX), DAP12-/-FcRγ-/- mice showed resistance to lumbar vertebral body (LVB) trabecular bone loss, while WT, DAP12-/- and FcRγ-/- mice had significant LVB bone loss. In contrast, all ITAM adapter-deficient mice responded to OVX with bone loss in both femur and tibia of approximately 40%, relative to basal bone volumes. Only WT mice developed significant cortical bone loss after OVX. In vitro studies showed microenvironmental changes induced by OVX are indispensable for enhanced osteoclast formation and function. Cytokine changes, including TGFβ and TNFα, were able to induce osteoclastogenesis independent of RANKL in BMMs from WT but not DAP12-/- and DAP12-/-FcRγ-/- mice. FSH stimulated RANKL-induced osteoclast differentiation from BMMs in WT, but not DAP12-/- and DAP12-/-FcRγ-/- mice. Our study demonstrates that although ITAM adapter signaling is critical for normal bone remodeling, estrogen-deficiency induces an ITAM adapter-independent bypass mechanism allowing for enhanced osteoclastogenesis and activation in specific bony microenvironments

Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts

Background—The standard test for the diagnosis of acute rejection in kidney transplants is the renal biopsy. Noninvasive tests would be preferable. Methods—We prospectively collected 4300 urine specimens from 485 kidney-graft recipients from day 3 through month 12 after transplantation. Messenger RNA (mRNA) levels were measured in urinary cells and correlated with allograft-rejection status with the use of logistic regression. Results—A three-gene signature of 18S ribosomal (rRNA)–normalized measures of CD3ε mRNA and interferon-inducible protein 10 (IP-10) mRNA, and 18S rRNA discriminated between biopsy specimens showing acute cellular rejection and those not showing rejection (area under the curve [AUC], 0.85; 95% confidence interval [CI], 0.78 to 0.91; P<0.001 by receiver-operatingcharacteristic curve analysis). The cross-validation estimate of the AUC was 0.83 by bootstrap resampling, and the Hosmer–Lemeshow test indicated good fit (P = 0.77). In an externalvalidation data set, the AUC was 0.74 (95% CI, 0.61 to 0.86; P<0.001) and did not differ significantly from the AUC in our primary data set (P = 0.13). The signature distinguished acute cellular rejection from acute antibody-mediated rejection and borderline rejection (AUC, 0.78; 95% CI, 0.68 to 0.89; P<0.001). It also distinguished patients who received anti–interleukin-2 receptor antibodies from those who received T-cell–depleting antibodies (P<0.001) and was diagnostic of acute cellular rejection in both groups. Urinary tract infection did not affect the signature (P = 0.69). The average trajectory of the signature in repeated urine samples remained below the diagnostic threshold for acute cellular rejection in the group of patients with no rejection, but in the group with rejection, there was a sharp rise during the weeks before the biopsy showing rejection (P<0.001). Conclusions—A molecular signature of CD3ε mRNA, IP-10 mRNA, and 18S rRNA levels in urinary cells appears to be diagnostic and prognostic of acute cellular rejection in kidney allografts