L’immigrazione nella trasformazione dei contesti urbani: il caso siciliano, l’esigenza del recupero culturale ed il rifiuto della marginalizzazione

The issue of the immigration leads to reorganize the whole social architecture of the societies in which it occurs. Considering the urban environment as a microcosm which has a great deal of influence on global dynamics, it is right to think about the living conditions of urban citizens who live in the multicultural present societies, often suffering marginalization. As the last researches claim, the local government system is the one that could help to deal with the immigration matter in the best way and this also needs to be urgently addressed, as the “Immigration in Sicily” case study could show

Coactivator condensation at super-enhancers links phase separation and gene control

Super-enhancers (SEs) are clusters of enhancers that cooperatively assemble a high density of the transcriptional apparatus to drive robust expression of genes with prominent roles in cell identity. Here we demonstrate that the SE-enriched transcriptional coactivators BRD4 and MED1 form nuclear puncta at SEs that exhibit properties of liquid-like condensates and are disrupted by chemicals that perturb condensates. The intrinsically disordered regions (IDRs) of BRD4 and MED1 can form phase-separated droplets, and MED1-IDR droplets can compartmentalize and concentrate the transcription apparatus from nuclear extracts. These results support the idea that coactivators form phase-separated condensates at SEs that compartmentalize and concentrate the transcription apparatus, suggest a role for coactivator IDRs in this process, and offer insights into mechanisms involved in the control of key cell-identity genes.National Institutes of Health (U.S.) (Grant GM123511)National Institutes of Health (U.S.) (Grant P01-CA042063)National Science Foundation (U.S.) (Grant PHY-1743900)National Cancer Institute (U.S.) (Grant P30-CA14051

Bare life in an immigration jail: technologies of surveillance in U.S. pre-deportation detention

This is an accepted manuscript of an article published by Taylor & Francis in Journal of Ethnic and Migration Studies on 29/08/2020, available online: https://doi.org/10.1080/1369183X.2020.1796266 The accepted version of the publication may differ from the final published version.Migration policies globally are characterised by a growth in the use of detention. These dynamics have also been noted in the United States of America, where, increasingly, the private immigration detention infrastructure is the most developed in the world. Like other total institutions, U.S. Immigration and Customs Enforcement (ICE) detention facilities depend on controlling human bodies. This article, which explains how nation-state sovereignty is created by means of surveillance technologies, draws upon the narratives of 26 Mexicans, deported under the administrations of Presidents Bush and Obama and interviewed in four waves of research between 2012 and 2019 in their hometown. The article describes the lived experience of biopolitical interventions on detainees’ bodies and explains the disciplining role of restricting or limiting access to ICTs. The article uses Agamben’s notion of bare life. It describes how biopolitical interventions and disciplines dehumanise precarious migrants and contribute to their governmentality long after their deportation when they abstain from re-entering the United States. The article complicates the notion of bare life by demonstrating that the use of biometrics (fingerprints) not only dehumanises people but also identifies their bodies and thus rehumanise them.Published onlin

Evaluation of the antioxidant and phototoxic potentials of Bauhinia microstachya var. massambabensis Vaz leaf extracts

Four different leaf extracts of B. microstachya var. massambabensis were studied to evaluate their antioxidant capacity by using three in vitro methods, with Ginkgo biloba and Trolox® as the standards. With the DPPH and ABTS·+ methods, the antioxidant activity of the extracts was in the following order, from maximum to minimum: AcEt > WAc > raw EtOH > EtOH CA > EGb, while with the ORAC method, it was as follows: EtOH CA > raw EtOH > AcEt > WAc > EGb. Phototoxic analysis was performed in yeast cultures of Saccharomyces cerevisiae. From the ethyl acetate extract, 2 flavonoids kaempferol-3-O-rhamnoside and astragalin-2”,6”-O-digallate were isolated and identified by HPLC and 1H- and 13C-NMR; to our knowledge, this is the first report of the occurrence of astragalin-2”,6”-O-digallate in the Bauhinia genus.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

The 14th St Gallen International Breast Cancer Conference (2015) reviewed new evidence on locoregional and systemic therapies for early breast cancer. This manuscript presents news and progress since the 2013 meeting, provides expert opinion on almost 200 questions posed to Consensus Panel members, and summarizes treatment-oriented classification of subgroups and treatment recommendation