1,2,4-TRIAZOLES: SYNTHETIC STRATEGIES AND PHARMACOLOGICAL PROFILES

Multicomponent, solid-phase, microwave and grinding methods are the constructive modes in the sustainable synthesis of 1, 2, 4-triazoles and such reactions have attracted enormous interest in recent years. The alternative reaction conditions getting popularity in the recent ecofriendly-economical time have been thoroughly investigated. Literature studies on 1, 2, 4-triazoles have shown that these derivatives possess broad spectrum of biological activities. This review focuses on synthetic strategies and pharmacological properties of 1, 2, 4-triazoles

Modeling Of Power Line Communication Channel For Automatic Meter Reading System With LDPC Codes

In this era of modernization, one of the promising emerging technologies is Power Line Communication (PLC) system. In previous research fields, modeling of PLC channel, mostly for indoor applications has been studied. However, the need to study that for outdoor applications, such as the Automatic Meter Reading (AMR) systems is also vital. Moreover, standardization bodies have considered the use of LDPC codes restricted for indoor systems. Thus, in this paper, not only we model the PLC channel based on AMR applications, but also, we apply LDPC coding scheme to the system. To accomplish the objectives, firstly, we model the PLC-AMR channel, which includes multipath phenomenon. Additionally, PLC noise, usually occurring in the channel, is modeled. The modulation technique applied is BPSK and the performance of the system with varying load impedances is compared. The coded system consists of irregular LDPC codes, with two different constructions of the Parity-Check matrix, namely that by Radford Neal and reduced size of DVBS2. The performances of respective systems are then compared. Using LDPC by Radford Neal, the performances are analyzed with varied code rates

SYNTHESIS AND ANTIBACTERIAL SCREENING OF FEW NEW 5-MEMBERED HETEROCYCLIC SUGAR HYDRAZONES

Objective: The aim of this study is to synthesize, characterize, and screen some new 5-membered heterocyclic sugar hydrazones for their antibacterialactivities.Methods: A library of sugar hydrazones containing 2-benzofuryl, 2-thiophenyl, and 2-pyrrolyl motifs were synthesized. Structures of the newlysynthesized compounds were deduced based on spectral data and elemental analyses.Results: Antibacterial activity was screened against Gram-positive and Gram-negative bacterial strains. Results were compared to gentamicin.Compound 6a exhibited most potent antibacterial activity against all the tested strains.Conclusion: 2-benzofuryl derivatives were observed to be good antibacterials.Keywords: Benzofuran, Thiophene, Pyrrole, Antibacterial, Sugar

Understanding the etiopathogenesis of Uttana Vatarakta (peripheral vascular disease) - An Observational Study

Advanced life style and changing food habits affects the activities of individual which leads to many diseases and Peripheral Vascular Diseases are one among them. They are characterized by reduction of blood flow and oxygen supply through peripheral vascular vessels. This can happen in arteries or veins. The incidence of Varicose vein is more common with age and high prevalence is after 30 years of life. PAD occurs in patients over 40 years old; the highest incidence occurs in the sixth and seventh decades of life and it affects 10-15% of the general population. The symptoms of Uttana Vatarakta owing to the Margavarana pathology simulate with the symptoms of Peripheral vascular diseases and some of the etiological factors of Uttana Vatarakta in the writing are specific in inclining Peripheral Vascular Diseases. Ayurveda emphasise the importance of study on etiopathogenesis of disease before the planning of treatment protocol. In this study an effort is done to identify the Nidanas and pattern of Samprapti in relation with Peripheral vascular diseases for the better understanding of different clinical presentations of Uttana Vatarakta

Self-reported discrimination and mental health among Asian Indians: Cultural beliefs and coping style as moderators.

The South Asian (SA) population has been underrepresented in research linking discrimination with health indicators; studies that focus on the unique cultural and psychosocial experiences of different SA subgroups are needed. The purpose of this study was to examine associations between self-reported discrimination and mental health among Asian Indians (AIs), and whether traditional cultural beliefs (believing that South Asian cultural traditions should be practiced in the US), coping style, and social support moderated these relationships. Asian Indians (N = 733) had been recruited from community-based sampling frames for the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study were included in this analysis. Multiple linear regression analyses were employed to evaluate relationships between discrimination and depressive symptoms, anger, and anxiety. Participants (men = 54%) were on average 55 years of age and had high levels of English proficiency, education, and income. Higher reports of discrimination were significantly associated with higher depressive symptoms, B = .27 (.05) p < .001, anger, B = .08 (.01), p < .001, and anxiety, B = .10 (.01), p < .001. Associations between discrimination and anger, B = −.005 (.002), p = .02, were weakest among those with stronger cultural beliefs. The link between discrimination and anxiety was attenuated by an active coping style, B = −.05 (.03), p = .04. In sum, self-reported discrimination appeared to adversely impact the mental health of AIs. Discrimination may be better coped with by having strong traditional cultural beliefs and actively managing experiences of discrimination

Hydrothermal from — Geology to Nanotechnology and Nanogeoscience (Part — II)

Hydrothermal process from a pure geologic science has now become one of the fast-emerging processing technologies to synthesize nanomaterials in the laboratory. Today it is an advanced technological tool, which facilitates to obtain nanomaterials and nanoparticles with desired size, shape, quality and functionality. In fact, hydrothermal technique has its bearing on the nature-inspired or geo-mimetic processes that are being employed extensively in the laboratory. The natural hydrothermal processes are acting ever since earth came into existence, and leading to the formation of a large variety of minerals, rocks and ores. Earth is a blue planet of the universe, where water is a major component which plays an important role in the formation of geological materials and hydrothermal circulation has always assisted by bacteria, photochemical and other related activities. The synthesis of advanced technological materials often occurs in the presence of biomolecules, proteins, organic ligands, DNA and amino acids. An understanding of nanogeoscience is becoming very relevant in the current context and is crossing into almost all the branches of geology including palaeoecology, mineralogy, environmental geology, energy geology, geochemistry, etc. Similarly, the hydrothermal processes in nature cover several branches of geology whether it is the origin of ores, minerals, rocks, but also life on the earth. In the present review, the authors discuss all the above aspects in detail with a future perspective of the field. Also, the authors have described the evolution of hydrothermal process from pure geology to the nanotechnology, nanogeoscience, nano-geopolymers, etc., with specific examples and depicted its relevance to the geologic science

Microbial quality of retort processed traditional Kerala chicken curry

The present study was carried out at the Department of Livestock Products Technology, College of Veterinary and Animal Sciences, Pookode and ICAR - Central Institute of Fisheries Technology, Kochi to develop retort processed traditional Kerala chicken curry and to evaluate its microbial quality. Traditional Kerala chicken curry was prepared using boneless chicken breast pieces and with a gravy of roasted coconut, spices and condiments. The product was packed in multilayer laminated pouch, which was then hermetically sealed and processed in an over-pressure retort. Accurate time-temperature standardisation was done to maintain sterility. The pouches were checked for commercial sterility after processing. The product was stored at ambient temperature and microbiological evaluation was conducted on days 0, 30, 60, 90 and 120 of storage. The curry showed no aerobic and anaerobic growth on different days of storage and did not spoil till day 120

Formative evaluation and adaptation of a hypertension Extension for Community Health Outcomes program for healthcare workers within the Federal Capital Territory, Nigeria

BACKGROUND: The Extension for Community Health Outcomes (ECHO) model has been used extensively to link care providers in rural communities with experts with the aim of improving local patient care. OBJECTIVE: The aim of this qualitative research study was to assess the feasibility, acceptability, perceived needs, and contextual factors to guide implementation of a hypertension focused ECHO program for Community Health Extension Workers (CHEWs) in the Federal Capital Territory, Nigeria. METHODS: From September 2020 to December 2020, key informant interviews were performed with seven global organizations (hubs) providing ECHO training focused on cardiovascular disease or nephrology to identify contextual factors and implementation strategies used by each hub. In February 2022, seven focus group discussions were performed with 42 frontline healthcare workers in the Federal Capital Territory to inform local adaptation of a hypertension ECHO program. Directed content analysis identified major themes which were mapped to the Consolidated Framework for Implementation Research. Qualitative analyses were performed using Dedoose, and results were synthesized using the Implementation Research Logic Model. RESULTS: We found both barriers and facilitators across the Consolidated Framework for Implementation Research domains that mapped to a number of constructs in each one. The results of these analyses confirmed that the core components of the ECHO model are a feasible and appropriate intervention for hypertension education of healthcare workers. However, implementing the ECHO program within the Federal Capital Territory may require strategies such as utilizing communications resources effectively, developing incentives to motivate initial participation, and providing rewards or recognition for ongoing engagement. CONCLUSIONS: These results provide valuable formative insights to guide implementation of our proposed hypertension ECHO program for CHEWs in the Federal Capital Territory, Nigeria. This information was used for key decisions around: 1) scope and content of training, 2) format and frequency, 3) selection of implementation strategies, and 4) building a community of practice

Associations Between Discrimination and Cardiovascular Health Among Asian Indians in the United States

Asian Indians (AI) have a high risk of atherosclerotic cardiovascular disease. The study investigated associations between discrimination and (1) cardiovascular risk and (2) self-rated health among AI. Higher discrimination scores were hypothesized to relate to a higher cardiovascular risk score (CRS) and poorer self-rated health. Asian Indians (n = 757) recruited between 2010 and 2013 answered discrimination and self-reported health questions. The CRS (0–8 points) included body-mass index, systolic blood pressure, total cholesterol, and fasting blood glucose levels of AI. Multiple linear regression analyses were conducted to evaluate relationships between discrimination and the CRS and discrimination and self-rated health, adjusting for psychosocial and clinical factors. There were no significant relationships between discrimination and the CRS (p ≥ .05). Discrimination was related to poorer self-reported health, B = −.41 (SE = .17), p = .02. Findings suggest perhaps there are important levels at which discrimination may harm health