Primary intraosseous mucoepidermoid carcinoma of the maxilla

Primary intraosseous mucoepidermoid carcinoma (PIOC) is an infrequent malignancy of the head and neck that exhibits diverse biological behavior. The rareness of the location for a salivary gland tumor and the clinical and radiographic manifestations, suggestive of an odontogenic lesion often pose a diagnostic challenge. We hereby report such a unique case of central mucoepidermoid carcinoma that presented in an ambiguous manner, developing in the maxilla and intruding into the adjacent vital structures, adding a literature review.Keywords: Mucoepidermoid carcinoma, salivary gland malignancy, maxilla, CT imaging,histopathologic pictur

Stabilization of Pickering Emulsions with Oppositely Charged Latex Particles: Influence of Various Parameters and Particle Arrangement around Droplets

© 2015 American Chemical Society. In this study we explore the fundamental aspects of Pickering emulsions stabilized by oppositely charged particles. Using oppositely charged latex particles as a model system, Pickering emulsions with good long-term stability can be obtained without the need for any electrolyte. The effects of parameters like oil to water ratio, mixed particle composition, and pH on emulsion type and stability are explored and linked to the behavior of the aqueous particle dispersion prior to emulsification. The particle composition is found to affect the formation of emulsions, viz., stable emulsions were obtained close to a particle number ratio of 1:1, and no emulsion was formed with either positively or negatively charged particles alone. The emulsions in particle mixtures exhibited phase inversion from oil-in-water to water-in-oil beyond an oil volume fraction of 0.8. Morphological features of emulsion droplets in terms of particle arrangement on the droplets are discussed

Coexistent antiphospholipid syndrome and myeloproliferative neoplasm

Antiphospholipid syndrome (APS) and myeloproliferative neoplasms (MPN) are associated with an increased risk of thrombosis. The optimal management of patients with coexistent APS and MPN has not been defined. A single centre and systematic literature review of patients with coexistent APS and MPN was performed. Cases were divided into two groups based on whether they met international consensus criteria for APS. Of the 12 studies identified, eight were excluded (leaving five of a total 54 patients), as although antiphospholipid antibodies (aPL) were documented, the diagnosis of APS was not conclusively demonstrated. Another ten patients with definite APS were identified at our centre. Fifteen patients (ten females, five males) were therefore included in this analysis (eleven definite APS and four highly likely), median age 44 (range: 13–71) years. Nine had polycythaemia vera and six, essential thrombocythaemia. Thirteen of the 15 patients (86.7%) had thrombotic APS (seven with initial venous events and six arterial) and two (13.3%) had obstetric APS. Nine patients were single-positive, and six double-positive for aPL. None were triple aPL-positive. Four patients at our centre had recurrent thrombotic/obstetric events, including while on anticoagulation/antiplatelet treatment

Inbreeding Depression and Ovule Pre-emption in 'Bulbine bulbosa' (R. Br.) Haw. (Asphodelaceae)

This thesis examines the causes of self-sterility and consequences of inbreeding on seed set and progeny fitness in 'Bulbine bulbosa' (Asphodelaceae). I conducted my research utilising both glasshouse plants and natural populations of 'B. bulbosa'. I investigated the causes of reduced self-fertility. Two mechanisms can be responsible for self-infertility in hermaphroditic flowers: physiological self-incompatibility and inbreeding depression. I conducted a histological investigation of ovule development after self- and cross-pollination, up to 7-days post-pollination. Examination of cleared specimens at 2-days post-pollination indicated that the mechanism reducing self-fertility was post-zygotic because double fertilisation was apparent after both self- and cross-pollination. This eliminated gametophytic and sporophytic self-incompatibility. Examinations of ovule development at 5- and 7-days post-pollination indicated that abortion was significantly higher after self-compared to cross-pollination. There was no indication that the arrest of selfed ovule development occurred at a single stage, eliminating a late-acting physiological self-incompatibility mechanism. The evidence indicated that reduced self-fertility was probably due to early-acting inbreeding depression. I conclude that inbreeding facilitated by both selfing and mating between related individuals is costly to 'B. bulbosa' populations. Inbreeding results in inbreeding depression causing ovules to abort reducing natural seed set. Consequently, these ovules are wasted and are unavailable for outcrossing. Inbreeding reduces fecundity and potentially recruitment to successive generations. Finally, inbreeding depression is a major selective force maintaining a predominately outcrossing mating system in 'B. bulbosa'

Nuclear proteome response to cell wall removal in rice (Oryza sativa)

Plant cells are routinely exposed to various pathogens and environmental stresses that cause cell wall perturbations. Little is known of the mechanisms that plant cells use to sense these disturbances and transduce corresponding signals to regulate cellular responses to maintain cell wall integrity. Previous studies in rice have shown that removal of the cell wall leads to substantial chromatin reorganization and histone modification changes concomitant with cell wall re-synthesis. But the genes and proteins that regulate these cellular responses are still largely unknown. Here we present an examination of the nuclear proteome differential expression in response to removal of the cell wall in rice suspension cells using multiple nuclear proteome extraction methods. A total of 382 nuclear proteins were identified with two or more peptides, including 26 transcription factors. Upon removal of the cell wall, 142 nuclear proteins were up regulated and 112 were down regulated. The differentially expressed proteins included transcription factors, histones, histone domain containing proteins, and histone modification enzymes. Gene ontology analysis of the differentially expressed proteins indicates that chromatin & nucleosome assembly, protein-DNA complex assembly, and DNA packaging are tightly associated with cell wall removal. Our results indicate that removal of the cell wall imposes a tremendous challenge to the cells. Consequently, plant cells respond to the removal of the cell wall in the nucleus at every level of the regulatory hierarchy.This item is part of the UA Faculty Publications collection. For more information this item or other items in the UA Campus Repository, contact the University of Arizona Libraries at [email protected]

Cleidocranial Dysplasia

Cleidocranial dysplasia (CCD) is a bone disorder with cranial malformations, dental abnormalities, clavicular hypoplasia or agenesis and narrow thorax which allows approximation ofshoulders in front of chest. We report a case of CCD and discuss about it

Anti-protein C antibodies and acquired protein C resistance in SLE: novel markers for thromboembolic events and disease activity?

OBJECTIVES: Risk factors for thromboembolism in SLE are poorly understood. We hypothesized a possible role for protein C, based on its dual activity in inflammation and haemostasis and on the evidence of an association between acquired activated protein C (APC) resistance (APCR) and high-avidity anti-protein C antibodies (anti-PC) with a severe thrombotic phenotype in venous thrombosis APS patients. METHODS: In a cross-sectional study of 156 SLE patients, the presence and avidity of IgG anti-PC was established by in house-ELISA, and APCR to exogenous recombinant human APC (rhAPC) and Protac (which activates endogenous protein C) was assessed by thrombin generation-based assays. Associations with aPL profile, thrombotic history and disease activity (BILAG and SLEDAI-2K) were also established. RESULTS: Anti-PC were detected in 54.5% of patients and APCR in 59%. Anti-PC positivity was associated with APCR to both rhAPC (P <0.0001) and Protac (P =0.0001). High-avidity anti-PC, detected in 26.3% of SLE patients, were associated with APCR in patients with thrombosis only (P <0.05), and with the development of thrombosis over time (range: 0-52 years; P =0.014). High-avidity anti-PC levels correlated with SLEDAI-2K (P =0.033) and total BILAG (P =0.019); SLEDAI-2K correlated inversely with APCR to Protac (P =0.004). CONCLUSION: Anti-PC occur in patients with SLE, independently of aPL profile, and are associated with APCR. High-avidity anti-PC are associated with thrombosis and with active disease and might prove a novel marker to monitor the risk of thrombosis and disease progression in SLE

Knowledge, anxiety levels and attitudes of infertile couples towards COVID-19 and its impact on self-funded fertility treatment : a cross-sectional questionnaire survey

Acknowledgement We thank the couples who were willing to participate in the study. Funding This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Peer reviewedPublisher PD

Experimentation and Optimization of Multilayered Aluminum-Based Functionally Graded Materials

According to current industrial and societal demands, product manufacturing is now highly competitive. The current research is primarily focused on the creation of functionally graded materials that are essential for automotive cylinders and their internal components. Since aluminum plays a significant role in automobile components, layerwise deposition of the matrix and reinforcements is used. Aluminum alloy (Al 356) was investigated in weight proportions of 100, 95, and 90%, while the reinforcement varied from 0 to 7.5%. The particulate reinforcements were chosen to be silicon carbide (SiC) and nickel (Ni). Zinc stearate is used as lubricating agent to enhance the free-flow compaction process and to avoid the wastage in synthesis. The compressed specimens were examined for various mechanical and microstructural characterization. An ultimate compressive strength of 328 MPa and 68 BHN was achieved at 85% Al, 5% SiC, and 7.5% Ni, as per research criterion. Scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), and X-ray diffraction analysis (XRD) images of the inclusions and matrix are compatible and compact due to the excellent bonding. The process variables were adjusted using Taguchi optimization, which shows that the sintering duration and compaction pressure are crucial for the validation of manufacturing and characterization