The Rules of Human T Cell Fate in vivo.

The processes governing lymphocyte fate (division, differentiation, and death), are typically assumed to be independent of cell age. This assumption has been challenged by a series of elegant studies which clearly show that, for murine cells in vitro, lymphocyte fate is age-dependent and that younger cells (i.e., cells which have recently divided) are less likely to divide or die. Here we investigate whether the same rules determine human T cell fate in vivo. We combined data from in vivo stable isotope labeling in healthy humans with stochastic, agent-based mathematical modeling. We show firstly that the choice of model paradigm has a large impact on parameter estimates obtained using stable isotope labeling i.e., different models fitted to the same data can yield very different estimates of T cell lifespan. Secondly, we found no evidence in humans in vivo to support the model in which younger T cells are less likely to divide or die. This age-dependent model never provided the best description of isotope labeling; this was true for naïve and memory, CD4+ and CD8+ T cells. Furthermore, this age-dependent model also failed to predict an independent data set in which the link between division and death was explored using Annexin V and deuterated glucose. In contrast, the age-independent model provided the best description of both naïve and memory T cell dynamics and was also able to predict the independent dataset

Erratum to: Daphnia revisited: local stability and bifurcation theory for physiologically structured population models explained by way of an example

In the original publication, the addresses of the authors Dr. J.A.J. Metz and Dr. S. Nakaoka were incorrectly published. The correct address list for the authors are: J.A.J. Metz: Institute of Biology and Institute of Mathematics, Leiden University, P.O. Box 9516, 2300RA Leiden, The Netherlands. S. Nakaoka: Graduate School of

A neural network-based estimate of the seasonal to inter-annual variability of the Atlantic Ocean carbon sink

The Atlantic Ocean is one of the most important sinks for atmospheric carbon dioxide (CO2), but this sink has been shown to vary substantially in time. Here we use surface ocean CO2 observations to estimate this sink and the temporal variability from 1998 through 2007 in the Atlantic Ocean. We benefit from (i) a continuous improvement of the observations, i.e. the Surface Ocean CO2 Atlas (SOCAT) v1.5 database and (ii) a newly developed technique to interpolate the observations in space and time. In particular, we use a two-step neural network approach to reconstruct basin-wide monthly maps of the sea surface partial pressure of CO2 (pCO2) at a resolution of 1° × 1°. From those, we compute the air–sea CO2 flux maps using a standard gas exchange parameterization and high-resolution wind speeds. The neural networks fit the observed pCO2 data with a root mean square error (RMSE) of about 10 μatm and with almost no bias. A check against independent time-series data and new data from SOCAT v2 reveals a larger RMSE of 22.8 μatm for the entire Atlantic Ocean, which decreases to 16.3 μatm for data south of 40° N. We estimate a decadal mean uptake flux of −0.45 ± 0.15 Pg C yr−1 for the Atlantic between 44° S and 79° N, representing the sum of a strong uptake north of 18° N (−0.39 ± 0.10 Pg C yr−1), outgassing in the tropics (18° S–18° N, 0.11 ± 0.07 Pg C yr−1), and uptake in the subtropical/temperate South Atlantic south of 18° S (−0.16 ± 0.06 Pg C yr−1), consistent with recent studies. The strongest seasonal variability of the CO2 flux occurs in the temperature-driven subtropical North Atlantic, with uptake in winter and outgassing in summer. The seasonal cycle is antiphased in the subpolar latitudes relative to the subtropics largely as a result of the biologically driven winter-to-summer drawdown of CO2. Over the 10 yr analysis period (1998 through 2007), sea surface pCO2 increased faster than that of the atmosphere in large areas poleward of 40° N, while in other regions of the North Atlantic the sea surface pCO2 increased at a slower rate, resulting in a barely changing Atlantic carbon sink north of the Equator (−0.01 ± 0.02 Pg C yr−1 decade−1). Surface ocean pCO2 increased at a slower rate relative to atmospheric CO2 over most of the Atlantic south of the Equator, leading to a substantial trend toward a stronger CO2 sink for the entire South Atlantic (−0.14 ± 0.02 Pg C yr−1 decade−1). In contrast to the 10 yr trends, the Atlantic Ocean carbon sink varies relatively little on inter-annual timescales (±0.04 Pg C yr−1; 1 σ)

Large Polarization Degree of Comet 2P/Encke Continuum Based on Spectropolarimetric Signals During Its 2017 Apparition

Spectropolarimetry is a powerful technique for investigating the physical properties of gas and solid materials in cometary comae without mutual contamination, but there have been few spectropolarimetric studies to extract each component. We attempt to derive the continuum polarization degree of comet 2P/Encke, free from influence of molecular emissions. The target is unique in that it has an orbit dynamically decoupled from Jupiter like main-belt asteroids, while ejecting gas and dust like ordinary comets. We observed the comet using the Higashi-Hiroshima Optical and Near-Infrared Camera attached to the Cassegrain focus of the 150-cm Kanata telescope on UT 2017 February 21 when the comet was at the solar phase angle of 75.7 deg. We find that the continuum polarization degree with respect to the scattering plane is 33.8+/-2.7 % at the effective wavelength of 0.815 um, which is significantly higher than those of cometary dust in a high-Pmax group at similar phase angles. Assuming that an ensemble polarimetric response of 2P/Encke's dust as a function of phase angle is morphologically similar with those of other comets, its maximum polarization degree is estimated to > 40 % at the phase angle of ~100 deg. In addition, we obtain the polarization degrees of the C2 swan bands (0.51-0.56 um), the NH2 alpha bands (0.62-0.69 um) and the CN-red system (0.78-0.94 um) in a range of 3-19 %, which depend on the molecular species and rotational quantum numbers of each branch. The polarization vector aligns nearly perpendicularly to the scattering plane with the average of 0.4 deg over a wavelength range of 0.50-0.97 um. From the observational evidence, we conjecture that the large polarization degree of 2P/Encke would be attributable to a dominance of large dust particles around the nucleus, which have remained after frequent perihelion passages near the Sun.Comment: 9 pages, 4 figures, accepted for publication in Astronomy & Astrophysic

Torsion pairs and rigid objects in tubes

We classify the torsion pairs in a tube category and show that they are in bijection with maximal rigid objects in the extension of the tube category containing the Pruefer and adic modules. We show that the annulus geometric model for the tube category can be extended to the larger category and interpret torsion pairs, maximal rigid objects and the bijection between them geometrically. We also give a similar geometric description in the case of the linear orientation of a Dynkin quiver of type A.Comment: 25 pages, 13 figures. Paper shortened. Minor errors correcte

Risk for Tuberculosis among Children

Risk among children is underestimated in countries with a high incidence of this disease

Stability Assessment of Regenerated Hierarchical ZSM-48 Zeolite Designed by Post-Synthesis Treatment for Catalytic Cracking of Light Naphtha

Hierarchical ZSM-48, a one-dimensional pore system zeolite with the presence of mesopores, was obtained by post-synthesis alkaline and acid treatments. Hierarchical ZSM-48 exhibited excellent hexane cracking activity compared to parent ZSM-48, which can be attributed to better diffusion as a result of the created mesoporosity. Moreover, the post-synthesis treatment allowed for manipulation of the distribution of active sites. Consequently, better stability and higher propylene selectivity were accomplished. The spent catalyst was regenerated by removing the deposited coke from the pores, and the regenerated catalyst was characterized again to investigate the recyclability of the hierarchical structure achieved. Parent ZSM-48 showed the same textural and acidic properties after regeneration, while the structure of the post-treated sample suffered from serious defects. The defects severely decreased the number of active sites as measured by pyridine Fourier transform infrared spectroscopy and caused major structural collapse as observed by scanning electron microscopy and transmission electron microscopy