Physiological roles of dietary glutamate signaling via gut–brain axis due to efficient digestion and absorption

Dietary glutamate (Glu) stimulates to evoke the umami taste, one of the five basic tastes, enhancing food palatability. But it is also the main gut energy source for the absorption and metabolism for each nutrient, thus, only a trace amount of Glu reaches the general circulation. Recently, we demonstrated a unique gut sensing system for free Glu (glutamate signaling). Glu is the only nutrient among amino acids, sugars and electrolytes that activates rat gastric vagal afferents from the luminal side specifically via metabotropic Glu receptors type 1 on mucosal cells releasing mucin and nitrite mono-oxide (NO), then NO stimulates serotonin (5HT) release at the enterochromaffin cell. Finally released 5HT stimulates 5HT(3) receptor at the nerve end of the vagal afferent fiber. Functional magnetic resonance imaging (f-MRI, 4.7 T) analysis revealed that luminal sensing with 1 % (w/v) monosodium l-glutamate (MSG) in rat stomach activates both the medial preoptic area (body temperature controller) and the dorsomedial hypothalamus (basic metabolic regulator), resulting in diet-induced thermogenesis during mealing without changes of appetite for food. Interestingly, rats were forced to eat a high fat and high sugar diet with free access to 1 % (w/w) MSG and water in a choice paradigm and showed the strong preference for the MSG solution and subsequently, they displayed lower fat deposition, weight gain and blood leptin. On the other hand, these brain functional changes by the f-MRI signal after 60 mM MSG intubation into the stomach was abolished in the case of total vagotomized rats, suggesting that luminal glutamate signaling contributes to control digestion and thermogenesis without obesity

Transverse Dynamics for Super-Rapid Acceleration in Circular High-Energy Particle Accelerators

A new particle acceleration concept had been presented to realize a short acceleration time of µs to produce high-energy muons in circular accelerators. The acceleration method is also expected to accelerate heavy-mass particles with large momentum spread: protons, deuterons, and various heavy ions. It is most important to develop a beam injection method into a main accelerator and to investigate the vertical motion of particles, especially for heavy ion acceleration. The outlines of beam injection method and beam focusing method to solve the vertical divergence problem, which causes the beam loss, are shown in this paper. In addition, a new compact magnet system, which produces magnetic field like a quadrupole field for beam focusing especially in wide aperture accelerators, is also described here

Developments on Next-Generation Beam Handling of High-Energy Particles by using Non-linear Characteristics

Various developments had been conducted to produce a fast-response magnet by the traditional concepts based on the use of linear-characteristic elements, but the improvement is limited by the transmission theory. The application of non-linear phenomena is important to achieve further improvements. The recent progress and the future plan of the developments to produce a fast-response and strong field for high-energy particle handling are described here

New Approach for Designing of High-Energy Circular Particle Accelerators

New particles and new nuclei have been discovered by artificial techniques recently. High-energy particle accelerators work the important roles to bring such discoveries. The applications of the particles are being discussed at various communities as a next step to get new technologies. The life-time of the particles are very short to handle by conventional techniques. It can be extended by the theory of relativity. The compact particle accelerator, which enables rapid acceleration, is required especially for the industrial applications. The possibility to satisfy the isochronous condition in the case of DC and uniform magnetic field is discussed here by getting back to the fundamental theoretical approach

Magnetic dichroism study on Mn1.8_{1.8}Co1.2_{1.2}Ga thin film using a combination of X-ray absorption and photoemission spectroscopy

Using circularly polarised radiation and a combination of bulk-sensitive hard X-ray photoelectron spectroscopy and X-ray-absorption spectroscopy (XAS) we studied the electronic and magnetic structure of epitaxial Mn$_{1.8}$Co$_{1.2}$Ga thin films. Spin resolved Bloch spectral functions, density of states as well as charge and magnetisation densities were investigated by a first-principles analysis of full potential, fully relativistic Korringa--Kohn--Rostoker calculations of the electronic structure. The valence states were experimentally investigated by using linear dichroism in the angular distribution and comparing the results to spin-resolved densities of states. The linear dichroism in the valence band enabled a symmetry analysis of the contributing states. The spectra were in good agreement with the theoretical partial density of states. The element-specific, spin-resolved, unoccupied densities of states for Co and Mn were analysed by using XAS and X-ray magnetic circular dichroism (XMCD) at the $L_{3,2}$ edges. The spectra were influenced by strong correlation effects. XMCD was used to extract the site resolved magnetic moments. The experimental values of $m_{\rm Mn}=0.7\:\mu_B$ and $m_{\rm Co}=1.05\:\mu_B$ agree very well with the calculated magnetic moments. Magnetic circular dichroism in angle-resolved photoelectron spectroscopy at the Mn and Co $2p$ core level exhibited a pronounced magnetic dichroism and confirmed the localised character of the Mn $d$ valence states

Pure exploration in multi-armed bandits with low rank structure using oblivious sampler

In this paper, we consider the low rank structure of the reward sequence of the pure exploration problems. Firstly, we propose the separated setting in pure exploration problem, where the exploration strategy cannot receive the feedback of its explorations. Due to this separation, it requires that the exploration strategy to sample the arms obliviously. By involving the kernel information of the reward vectors, we provide efficient algorithms for both time-varying and fixed cases with regret bound $O(d\sqrt{(\ln N)/n})$. Then, we show the lower bound to the pure exploration in multi-armed bandits with low rank sequence. There is an $O(\sqrt{\ln N})$ gap between our upper bound and the lower bound.Comment: 15 page