Large Intrahepatic Cholangiocarcinoma with Tumor Infiltrative Lymphocytes and Autoimmune Hepatitis-Like Features

The development of a primary hepatic tumor associated with autoimmune hepatitis (AIH) has been rarely reported. This report describes a rare case of intrahepatic cholangiocarcinoma (ICC) that accompanied tumor infiltrative lymphocytes (TIL) and AIH-like features. Moreover, multiple early gastric cancers were recognized in synchrony. An 81-year-old male was admitted due to liver dysfunction. His laboratory data on admission showed an elevation of immunoglobulin G and a positive titer of antinuclear antibody. Biological tests for HBV and HCV were negative. Computed tomography showed a well-enhanced hepatic tumor and gastrointestinal fiberscopy revealed two early gastric cancers with mucosal invasion. Biopsies were obtained from the background liver and the hepatic tumor. Histologically, the tumor revealed adenocarcinoma and the liver showed piecemeal necrosis and interface hepatitis with lymphoplasmacytic infiltration. The patient underwent hepatectomy and distal gastrectomy. Finally, he was diagnosed to have a mass forming type ICC and early gastric cancers. Moreover, prominent TIL in the ICC was revealed. An analysis of the infiltrating lymphocytes by immunohistochemical staining suggested that there was a difference in the local immune response between the tumor and the background liver. Review of the literature showed that there are only three reports of ICC associated with AIH, if including the current case

Quantification of Lung Perfusion Blood Volume in Dual-Energy Computed Tomography in Patients with Pulmonary Hypertension

Dual-energy computed tomography (DECT) is a promising technique for the assessment of the lung perfused blood volume (LPBV) in the lung parenchyma. This study was performed to compare the LPBV by DECT of patients with pulmonary hypertension (PH) and controls and to evaluate the association between the LPBV and the perfusion ratio derived by lung perfusion scintigraphy. This study involved 45 patients who underwent DECT (25 patients with PH and 20 controls). We measured the total LPBV and distribution of the LPBV in each lung. The total LPBV was significantly lower in the PH group than the control group (38 +/- 9 vs. 45 +/- 8 HU, p = 0.024). Significant differences were observed between the LPBV of the upper lung of the PH and control groups (34 +/- 10 vs. 47 +/- 10, p = 0.021 and 37 +/- 10 vs. 47 +/- 8, p < 0.001). A significant correlation was observed between the LPBV and the lung perfusion scintigraphy. A lower total LPBV and lower LPBV of the upper lung as detected by DECT might be specific findings of PH

Ratioless full-complementary 12-transistor static random access memory for ultra low supply voltage operation

In this study, a ratioless full-complementary 12-transistor static random access memory (SRAM) was developed and measured to evaluate its operation under an ultra low supply voltage range. The ratioless SRAM design concept enables a memory cell design that is free from the consideration of the static noise margin (SNM). Furthermore, it enables a SRAM function without the restriction of transistor parameter (W/L) settings and the dependence on the variability of device characteristics. The test chips that include both conventional 6-transistor SRAM cells and the ratioless full-complementary 12-transistor SRAM cells were developed by a 180 nm CMOS process to compare their stable operations under an ultralow supply voltage condition. The measured results show that the ratioless full-complementary 12-transistor SRAM has superior immunity to device variability, and its inherent operating ability at the supply voltage of 0.22 V was experimentally confirmed

Full Particle Simulation of Whistler-Mode Triggered Falling-Tone Emissions in the Magnetosphere

We perform a one‐dimensional electromagnetic full particle simulation for triggered falling‐tone emissions in the Earth's magnetosphere. The equatorial region of the magnetosphere is modeled with a parabolic magnetic field approximation. The short whistler‐mode waves with a large amplitude are excited and propagate poleward from an artificial current oscillating with a constant frequency and amplitude. Following the excited waves, clear emissions are triggered with a falling frequency. Without the inhomogeneity of the background magnetic field, no triggered emission appears. The falling tone has several subpackets of amplitude and decreases the frequency in a stepwise manner. The positive resonant current formed by resonant electrons in the direction of the wave magnetic field clearly shows that an electron hill is formed in the phase space and causes the frequency decrease. The entrapping of the resonant electrons at the front of the packets and the decrease of the amplitude at the end of packets are essential for the generation of falling‐tone emissions. Each wavefront of the emission has a strongly negative resonant current −JE, which results in the wave growth. In the formation process of the resonant currents, we investigate the inhomogeneous factor S, which controls the nonlinear motion of the resonant electrons interacting with waves. The factor S consists of two terms, a frequency sweep rate and a gradient of the background magnetic field. The resonant current JE in the wave packet changes its sign from negative to positive as the packet moves away from the equator, terminating the wave growth

Usefulness of Immunoglobulin Light-Chain Restriction on Immunocytochemical Double Staining for the Cytological Diagnosis of B Cell Non-Hodgkin's Lymphoma

Objective: We examined the usefulness of light-chain restriction (LCR) on immunocytochemical double staining (IDS) for cytological diagnosis. Study Design: We investigated LCR on IDS in 40 patients with proliferative lymphatic disorders (23 with B cell lymphoma, 13 with reactive lymphoid lesions, 2 with T cell lymphoma and 2 with Hodgkin's lymphoma). In addition, the results of flow cytometry (FCM) were compared in 34 of these patients. Results: On IDS, LCR was detected in 21 of 23 patients (91.3%) with B cell lymphoma. On FCM, it was detected in 15 of 21 patients (71.4%) with B cell lymphoma. Neither IDS nor FCM showed LCR in any patients with reactive lesions, T cell lymphoma or Hodgkin's lymphoma. Conclusion: IDS facilitated the detection of LCR with a single specimen under morphological observation. The application of this procedure may improve the accuracy of cytological diagnosis

Rate of Family Violence Among Patients With Schizophrenia in Japan

Kageyama, M., Yokoyama, K., Nagata, S., Kita, S., Nakamura, Y., Kobayashi, S., & Solomon, P. (2015). Rate of Family Violence Among Patients With Schizophrenia in Japan. Asia Pacific Journal of Public Health, 27(6), pp. 652–660. © 2015 APJPH. DOI: 10.1177/101053951559506

Relationship Between Balance Recovery From a Forward Fall and Lower-Limb Rate of Torque Development

The authors examined the relationship between the maximum recoverable lean angle via the tether-release method with early- or late-phase rate of torque development (RTD) and maximum torque of lower-limb muscle groups in 56 young healthy adults. Maximal isometric torque and RTD at the hip, knee, and ankle were recorded. The RTD at 50-ms intervals up to 250 ms from force onset was calculated. The results of a stepwise multiple regression analysis, early RTD for hip flexion, and knee flexion were chosen as predictive variables for the maximum recoverable lean angle. The present study suggests that some of the early RTD in the lower limb muscles, but not the maximum isometric torque, can predict the maximum recoverable lean angle