Deciphering the role of Epstein-Barr virus in the pathogenesis of T and NK cell lymphoproliferations

Epstein-Barr virus (EBV) is a highly successful herpesvirus, colonizing more than 90% of the adult human population worldwide, although it is also associated with various malignant diseases. Primary infection is usually clinically silent, and subsequent establishment of latency in the memory B lymphocyte compartment allows persistence of the virus in the infected host for life. EBV is so markedly B-lymphotropic when exposed to human lymphocytes in vitro that the association of EBV with rare but distinct types of T and NK cell lymphoproliferations was quite unexpected. Whilst relatively rare, these EBV-associated T and NK lymphoproliferations can be therapeutically challenging and prognosis for the majority of patients is dismal. In this review, we summarize the current knowledge on the role of EBV in the pathogenesis of these tumours, and the implications for treatment. \ud \u

Sexual Violence and the Role of Public Conversations in Japan: A Closer Look at the “Bakky Case”

While the #MeToo movement has led to successful campaigns against sexual harassment in many parts of the world, results have been mixed in Japan. In spite of the fact that #MeToo has inspired a number of offshoot campaigns, many victims of sexual abuse remain silent. Greater attention needs to be directed at the reasons for this reluctance to pursue justice. One factor that requires greater scrutiny is the role of public conversations; that is, widely reported comments from prominent members of society which generate some level of discussion and which exercise some influence over people’s way of thinking on particular topics. If public conversations denigrate women by labeling them as sexually promiscuous or as failures in terms of normative motherhood, the result may be increased violence against women and greater difficulty for women who seek justice in the aftermath of sexual violence. This argument is developed in this article which explores the ways in which a set of public conversations during the 1990’s and early 2000’s may have helped to incite extreme reactions of sexual abuse by stigmatizing certain young women both in terms of masculinist norms of sexuality and of female reproduction. Through engagement with relevant texts and member-checking with gender activists, the author found that the failure to learn lessons from a case of pornography-related sexual violence in the early 2000’s (referred to as the “Bakky case”) means that women remain vulnerable, especially if they are stigmatized for “failing in their duty” to bear children. Prominent figures in society must refrain from initiating public conversations that can lead to the stigmatization of women who challenge traditional gender norms. This study is made so that concerned citizens in Japan today, and readers everywhere, can more strongly justify their insistence on public conversations that reflect principles of gender equality and respect

The role of nucleoporin Nup58 during cell division

Nuclear pore complexes (NPCs) are transport channels between the nucleus and the cytoplasm. The NPCs are composed by around 30 different proteins, termed nucleoporins (Nups) and each Nup is present in multiple copies. Recently, we and others discovered that several nucleoporins play critical roles during cell division including chromosome condensation, sister chromatid cohesion, kinetochore assembly and spindle formation. Nup58 is a part of the central transport channel of the NPC, which forms a complex protein with other nucleoporins such as Nup62 and Nup54. Recently, we showed that Nup62 plays a novel role in centrosome integrity. Here, we show that Nup62 interacts with Nup58 during cell mitosis. Next, we performed RNA interference-mediated knockdown of Nup58. Currently, we are investigating Nup58 depletion effect in cell cycle