515 research outputs found

    Breaking Bread: Holistically Meeting Needs to Increase Writing Tutorial Success and Engagement

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    Students need writing tutoring, yet attendance for tutoring is epidemically low. Learn how an embedded tutoring program/center for English and ESL students increases student success and attendance for tutoring by providing “Brain Food” during tutoring sessions. Learn how breaking bread on your campus can meet students’ needs and change everything

    Dynamical Causes of the 2010/11 Texas–Northern Mexico Drought

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    The causes of the Texas–northern Mexico drought during 2010–11 are shown, using observations, reanalyses, and model simulations, to arise from a combination of ocean forcing and internal atmospheric variability. The drought began in fall 2010 and winter 2010/11 as a La Niña event developed in the tropical Pacific Ocean. Climate models forced by observed sea surface temperatures (SSTs) produced dry conditions in fall 2010 through spring 2011 associated with transient eddy moisture flux divergence related to a northward shift of the Pacific–North American storm track, typical of La Niña events. In contrast the observed drought was not associated with such a clear shift of the transient eddy fields and instead was significantly influenced by internal atmospheric variability including the negative North Atlantic Oscillation of winter 2010/11, which created mean flow moisture divergence and drying over the southern Plains and southeast United States. The models suggest that drought continuation into summer 2011 was not strongly SST forced. Mean flow circulation and moisture divergence anomalies were responsible for the summer 2011 drought, arising from either internal atmospheric variability or a response to dry summer soils not captured by the models. The summer of 2011 was one of the two driest and hottest summers over recent decades but it does not represent a clear outlier to the strong inverse relation between summer precipitation and temperature in the region. Seasonal forecasts at 3.5-month lead time did predict onset of the drought in fall and winter 2010/11 but not intensification into summer 2011, demonstrating the current, and likely inherent, inability to predict important aspects of North American droughts

    Hydrogen Peroxide Triggers a Dual Signaling Axis To Selectively Suppress Activated Human T Lymphocyte Migration

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    H2O2 is an early danger cue required for innate immune cell recruitment to wounds. To date, little is known about whether H2O2 is required for the migration of human adaptive immune cells to sites of inflammation. However, oxidative stress is known to impair T cell activity, induce actin stiffness, and inhibit cell polarization. In this study, we show that low oxidative concentrations of H2O2 also impede chemokinesis and chemotaxis of previously activated human T cells to CXCL11, but not CXCL10 or CXCL12. We show that this deficiency in migration is due to a reduction in inflammatory chemokine receptor CXCR3 surface expression and cellular activation of lipid phosphatase SHIP-1. We demonstrate that H2O2 acts through an Src kinase to activate a negative regulator of PI3K signaling, SHIP-1 via phosphorylation, providing a molecular mechanism for H2O2-induced chemotaxis deficiency. We hypothesize that although H2O2 serves as an early recruitment trigger for innate immune cells, it appears to operate as an inhibitor of T lymphocyte immune adaptive responses that are not required until later in the repair process
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