Rb-Sr age of K-rich LL-chondrite Yamato-74442

Yamato-74442, a brecciated LL-group chondrite, consists of fragments with igeous texture, chondrules, mineral fragments, and host. The fragments involve K-rich fragments as well as normal ones. Typically, both fragments consist mainly of euhedral porphyritic olivines and a few orthopyroxenes in a glassy grundmass. EPMA analyses for these fragments indicate that olivines and orthoptroxenes have a range of Fe/(Fe+Mg) ratio of 27.19～31.33 and 20.10～26.91 mol%, respectively. There is no significant difference in these rations between K-rich (Na2O/K2O<1) and normal framents. The K2O contents of groundmass for K-rich fragments range from 0.51 to 4.89 wt% and that of the normal fragments is 0.38～090 wt%. K2O contents of groundmass vary from fragment to fragment but are rather homegeneous in a single fragment. Rb-Sr isotopic determination on eighteen K-rich fragments (1.5 to 9.5mg in weight) gave an internal isochron age of 4.514±0.022 (2σ) Ga (λ87Rb=1.42×10-11y-1) and initial 87Sr/86Sr ratio of 0.7016±0.0024. This age is somewhat old compared with a whole rock isochron age of LL chondrites (4.493±0.18 Ga; Minster and Allegre, 1981). From a comoarison of the present result with others so far reported, it is inferred that the alkali differentiation as observed in Yamato-74442 probably occurred prior to or during a process of accumulation from LL chondrite parent material in the early solar nebula.

Purification and Properties of Hyaluronidase (EC 4. 2. 2. 1) from an Oral Strain of Propionibacterium acnes

From a culture supernatant of P. acnes isolated from a lesion of periodontal disease, hyaluronidase was purified to homogeneity by the sequential procedures including ammonium sulfate precipitation, carboxy methy-cellulose column chromatography, and Sephadex G-100 gel filtration. Specific activity increased 1,027 fold and the recovery of the enzymatic activity was 12.4%. Molecular weight was determined to be 67,000 and isoelectric point was 7.2. Optimal pH for the activity was found at 5.5. The enzyme was inactivated by heating at 60℃ for 10 min. The purified hyaluronidase degraded hyaluronic acid, chondroitin, chondroitin sulfate A and chondroitin sulfate C. From the degradation products of these substrates, unsaturated disaccharides were detected by paper chromatography. When the rate of reaction of this enzyme against hyaluronic acid is supposed to be 100%, the corresponding values against chondroitin, chondroitin sulfate A, and C were 47%, 8%, and 8%, respectively. No degradation by this enzyme of heparin and heparan sulfate was demonstrated

Solar thermophotovoltaic using Al2O3/Er3 Al5O12 eutectic composite selective emitter

科研費報告書収録論文(課題番号:11555057・基盤研究(B)(2)・H11～H13/研究代表者:湯上, 浩雄/太陽熱光起電力による高温輻射-電力直接変換システムの開発

Comparative Studies of Acid and Alkaline Phosphatases from Bacteroides melaninogenicus

Acid and alkaline phosphatases from an oral strin of Bacteroides melaninogenicus were purified to homogeneity from cell extracts and their properties were compared. Molecular weights of acid and alkaline phosphatases were estimated to be 62,000 and 160,000, respectively. Michaelis constant for p-nitrophenylphosphate of the acid phosphatase was 0.17 mM and that of the alkaline enzyme was 0.23 mM. The alkaline phosphatase was more stable than the acid phospatase when they were heated at 60℃. The activity of the acid phosphatase was largely reduced by Cu^ or fluoride and the alkaline phosphatase was quite sensitive to inhibition by Zn^, thiol compounds, or EDTA. The inactivation by EDTA of the alkaline phosphatase was restored with Ca^ or Mg^. The acid phosphatase hydrolyzed α-D-glucose 1.6-diphosphate, p-nitrophenylphos-phate, D-glucose 6-phosphate, and D-fructose 6-phosphate. On the other hand, p-nitro-phenylphosphate was the most suitable substrate for the alkaline phosphatase. Nucleoside triphosphates were also hydrolyzed by the alkaline phosphatase

下顎第3大臼歯の萌出程度と下顎骨の形態について

Recent studies have indicated that even in cases in which the existence of tooth germs are observed, third molars cannot perfectly erupt because there is too little space for eruption in the distal end of the 2nd molar, and that cases of impaction or semi-impaction are increasing. The purpose of this study was to compared the morphological variation of the mandible as the mandibular corpus and the mandibular ramus among three groups: a group of full impaction of the third molar in the mandibular dental arch (A group), a group of semi-impaction (B group), and a group of full eruption (C group). The following results were obtained. 1) Concerning the measurements representing distance: R (the width of the mandibular ramus), was significantly longer in group A while it was shorter in group C. M (total length of the mandible), C (length of the mandibular corpus) and the distance between Cd and Gn were all significantly longer in group C than in group A. 2) Concerning the measurements representing angles, the Go angle was significantly larger in group C than in group A. 3) All the measurements in group B approached the median value of those of group A and group C. It was suggested that there was no impaction of the mandibular third molar observed due to the reduction of the mandible, and that the eruption of the mandibular third molars appears to be affected by the growth and change in the mandibular corpus and the mandibular ramus and/or the change in the Go angle

Reliability and Validity of the Japanese Version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale in Kidney Transplant Recipients

A valid and reliable instrument that can measure adherence is needed to identify nonadherent patients and to improve adherence. However, there is no validated Japanese self-report instrument to evaluate adherence to immunosuppressive medications for transplant patients. The purpose of this study was to determine the reliability and validity of the Japanese version of the Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS).; We translated the BAASIS into Japanese and developed the Japanese version of the BAASIS (J-BAASIS) according to the International Society of Pharmacoeconomics and Outcomes Research task force guidelines. We analyzed the reliability (test-retest reliability and measurement error) and validity of the J-BAASIS (concurrent validity with the medication event monitoring system and the 12-item Medication Adherence Scale) referring to the COSMIN Risk of Bias checklist.; A total of 106 kidney transplant recipients were included in this study. In the analysis of test-retest reliability, Cohen's kappa coefficient was found to be 0.62. In the analysis of measurement error, the positive and negative agreement were 0.78 and 0.84, respectively. In the analysis of concurrent validity with the medication event monitoring system, sensitivity and specificity were 0.84 and 0.90, respectively. In the analysis of concurrent validity with the 12-item Medication Adherence Scale, the point-biserial correlation coefficient for the "medication compliance" subscale was 0.38 (; P; < 0.001).; The J-BAASIS was determined to have good reliability and validity. Using the J-BAASIS to evaluate adherence can help clinicians to identify medication nonadherence and institute appropriate corrective measures to improve transplant outcomes