Microfinance Institutions as a Vehicle for Poverty Eradication in Developing Countries: Evidence from the East African Community Member States

This paper focuses on examining the link that exists between microfinance institutions (MFIs) and poverty eradication efforts in developing countries, specifically focusing on the East African member states of Burundi, Democratic Republic of Congo (DRC), Kenya, Rwanda, South Sudan, Tanzania, and Uganda. The study was driven by the varying interpretations, debates, and opposing opinions in literature on the effects of MFIs on poverty eradication in developing economies, particularly in the East African Community (EAC). The study used a depth literature search using secondary data on the role of MFIs in poverty eradication in the EAC context. The results pointed out that despite the challenges such as high transaction rates, limited funding and others, microfinance credit has played a significant role in poverty eradication among poor/low-income families in the EAC Member States. Therefore, the study recommends that governments of the EAC Member States should increase government support, and conducive working environments should be provided to ensure microfinance institutions reach as many less privileged individuals as possible so as to raise their economic status

Somatic embryo production and GFP genetic transformation in elite Ugandan cassava genotypes

Friable embryogenic callus (FEC) production is a prerequisite for the genetic transformation of cassava (Manihot esculenta Crantz). This process necessitates the development of organized embryogenic structures (OES) as a precursor. However, the production of OES and FECs in cassava is dependent on the genotype. This study aimed to optimize somatic embryo production in elite Ugandan cassava genotypes (NASE13, NASE19, and NAROCASS1) and demonstrate genetic transformation using the enhanced green fluorescent protein (eGFP) gene. OES were induced by initiating leaf-lobe explants on Murashige and Skoog (MS) media at various concentrations of 24D and picloram followed by friable embryogenic callus (FEC) production and regeneration. There were highly significant differences among the different media compositions in the percentage response to OES formation (p < 0.001). NASE 13 exhibited the highest regeneration frequency of 38.4%; while NAROCASS1 had the lowest regeneration frequency of 10.5% recorded. The presence of GFP gene in NAROCASS1 was confirmed by polymerase chain reaction (PCR) analysis of the transformed lines. Compared to existing studies, this research pioneers genotype-specific optimization for somatic embryo production and successful genetic transformation in Ugandan cassava variaties. The utilization of these genotypes, already embraced by farmers, presents promising opportunities to enhance them with desirable traits, further augmenting cassava cultivation

Nutraceutical and antinutritional properties of wild edible plants consumed by pregnant women and school-age children (6-12 years) in Najjembe sub-county, Buikwe district, Uganda

Wild edible plants (WEPs) immensely contribute to the diets and livelihoods of rural and marginalised communities. In rural Uganda, they play an important role as break tea packages for school-age children and due to their perceived nutraceutical significance, they are always added to the diets of pregnant women. In this study, it was hypothesised that Basella alba L. (Malabar spinach, Ceylon spinach, Indian spinach, Vine spinach, Malabar nightshade), Termitomyces microcarpus (Berk. & Broome) R. Heim (Cendawan Tali; Cendawan Taugeh) Cucurbita pepo L. (Courgette, Marrow, Pumpkin, Summer squash, Table queen squash, Vegetable Marrow, Zucchini) and Solanum anguivi L. (Forest bitter berry, African eggplant) have high nutraceutical significance and could contribute to the diets of school-age children and pregnant women. Using the standard Association of Official Analytical Chemists (AOAC) methods (method 935.14 and 992.24), the nutraceuticals and antinutrients in B. alba, T. microcarpus, C. pepo, and S. anguivi were investigated. All analyses and measurements were done in triplicate to increase the validity and reliability of the results. Solanum anguivi had the highest crude fibre (25.22±0.08 %), fat (6.55±0.05 %), and energy (371.37±1.17 Kcal) content. Termitomyces microcarpus had the highest protein (21.99±0.16 %) and moisture (10.71±0.35 %) content. Basella alba and C. pepo had the highest ash (19.39±0.01 %) and total carbohydrate (69.15±0.62 %) content. In comparison with the recommended dietary daily intakes for pregnant mothers and school-going children, all the plants had high Potassium, Phosphorous contents (except for T. Microcarpus which had low K contents), iron, copper, zinc, and manganese., but with selenium content being below the detection limit. All the analysed species were good in antioxidants, C. Pepo being the best with an IC50 of 11.78±0.47 mg/ mL followed by B. alba (14.69±0.74 mg/ mL). Solanum anguvi and T. microcarpus had the highest amount of phenols (14.48±0.02 mg/g GAE) and tannins (0.42±0.00 mg/g GAE). Basella alba had the highest amounts of flavonoids (2.45±0.01 mg/g RAE). All the plant species had low contents of phytates ranging from (0.40±0.01 for S. Anguivi to 0.72±0.08 for B. Alba). Cadmium and lead concentrations were below the permissible limit recommended by FAO/WHO Expert Committee in Food Additives. Thus, the analysed WEPs are a rich source of important nutrients and can be used to complement staple foods to ensure balanced nutrition for pregnant women and school-age children. Nonetheless, further comprehensive antinutrients and heavy metals analyses should be conducted to ensure that they do not affect the bioavailability of the nutrients. For value addition, nutrient-dense cocktails / phytonutraceuticals should be developed to alleviate malnutrition-related illnesses in vulnerable groups of people

Activation of p38 and p42/44 MAP kinase in neuropathic pain: Involvement of VPAC2 and NK2 receptors and mediation by spinal glia

Activation of intracellular signaling pathways involving p38 and p42/44 MAP kinases may contribute importantly to synaptic plasticity underlying spinal neuronal sensitization. Inhibitors of p38 or p42/44 pathways moderately attenuated responses of dorsal horn neurons evoked by mustard oil but not brush and alleviated the behavioral reflex sensitization seen following nerve injury. Activation of p38 and p42/44 MAP kinases in spinal cord ipsilateral to constriction injury was reduced by antagonists of NMDA, VPAC2 and NK2 (but not related) receptors, the glial inhibitor propentofylline and inhibitors of TNF-α. A VPAC2 receptor agonist enhanced p38 phosphorylation and caused behavioral reflex sensitization in naïve animals that could be blocked by co-administration of p38 inhibitor. Conversely, an NK2 receptor agonist activated p42/44 and caused behavioral sensitization that could be prevented by co-administration of p42/44 inhibitor. Thus, spinal p38 and p42/44 MAP kinases are activated in neuropathic pain states by mechanisms involving VPAC2, NK2, NMDA receptors and glial cytokine production. © 2005 Elsevier Inc. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe