192 research outputs found
Localized knowledge spillovers and patent citations: A distance-based approach
We develop a new approach to localized knowledge spillovers by incorporating the concept of control patents (Jaffe, Trajtenberg and Henderson 1993) into the distance-based test of localization (Duranton and Overman, 2005). Using microgeographic data, we identify localization distance while allowing for cross-boundary spillovers, unlike the existing literature where the extent of localized knowledge spillovers is detected at the state or metropolitan statistical area level. We revisit the recent debate by Thompson and Fox-Kean (2005) and Henderson, Jaffe and Trajtenberg (2005) on the existence of localized knowledge spillovers, and find solid evidence supporting localization, even when finer controls are used.
Cloud optical thickness and effective particle radius derived from transmitted solar radiation measurements : Comparison with cloud radar observations
A method is presented for determining the optical thickness and effective particle radius of stratiform clouds containing liquid water drops in the absence of drizzle from transmitted solar radiation measurements. The procedure compares measurements of the cloud transmittance from the ground at water-absorbing and nonabsorbing wavelengths with lookup tables of the transmittance precomputed for plane-parallel, vertically homogeneous clouds. The optical thickness derived from the cloud transmittance may be used to retrieve vertical profiles of cloud microphysics in combination with the radar reflectivity factor. To do this, we also present an algorithm for solving the radar equation with a constraint of the optical thickness at the visible wavelength. Observations of clouds were made in August and September 2003 at Koganei, Tokyo, Japan, using a PREDE i-skyradiometer and a 95-GHz cloud radar Super Polarimetric Ice Crystal Detection and Explication Radar (SPIDER). The optical thickness and effective radius of water clouds were derived from the i-skyradiometer. Then, the vertical profile of the effective radius was retrieved from SPIDER, using the optical thickness determined from the i-skyradiometer. We found that the effective radii derived by using these two instruments were in good agreement
Electron acceleration with improved Stochastic Differential Equation method: cutoff shape of electron distribution in test-particle limit
We develop a method of stochastic differential equation to simulate electron
acceleration at astrophysical shocks. Our method is based on It\^{o}'s
stochastic differential equations coupled with a particle splitting, employing
a skew Brownian motion where an asymmetric shock crossing probability is
considered. Using this code, we perform simulations of electron acceleration at
stationary plane parallel shock with various parameter sets, and studied how
the cutoff shape, which is characterized by cutoff shape parameter , changes
with the momentum dependence of the diffusion coefficient . In the
age-limited cases, we reproduce previous results of other authors,
. In the cooling-limited cases, the analytical expectation
is roughly reproduced although we recognize deviations to
some extent. In the case of escape-limited acceleration, numerical result fits
analytical stationary solution well, but deviates from the previous asymptotic
analytical formula .Comment: corrected typos, 10 pages, 4 figures, 2 tables, JHEAp in pres
Effective and Steady Differentiation of a Clonal Derivative of P19CL6 Embryonal Carcinoma Cell Line into Beating Cardiomyocytes
The P19CL6 cell line is a useful model to study cardiac differentiation in vitro. However, large variations were noticed in the differentiation rates among previous reports as well as our individual experiments. To overcome the unstable differentiation, we established P19CL6-A1, a new clonal derivative of P19CL6 that could differentiate into cardiomyocytes more efficiently and stably than the parent using the double stimulation with 5-Aza and DMSO based on the previous report. We also introduced a new software, Visorhythm, that can analyze the temporal variations in the beating rhythms and can chart correlograms displaying the oscillated rhythms. Using P19CL6-A1-derived cardiomyocytes and the software, we demonstrated that the correlograms could clearly display the enhancement of beating rates by cardiotonic reagents. These indicate that a combination of P19CL6-A1 and Visorhythm is a useful tool that can provide invaluable assistance in inotropic drug discovery, drug screening, and toxicity testing
The Stellar Mass, Star Formation Rate and Dark Matter Halo Properties of LAEs at
We present average stellar population properties and dark matter halo masses
of \lya emitters (LAEs) from SED fitting and clustering analysis,
respectively, using objects () in four separate
fields of deg in total. With an average stellar mass of and star formation rate of , the LAEs lie on an extrapolation
of the star-formation main sequence (MS) to low stellar mass. Their effective
dark matter halo mass is estimated to be $4.0_{-2.9}^{+5.1} \times 10^{10}\
{\mathrm M_\odot}1.22^{+0.16}_{-0.18}z \sim 21.8\, \pm\, 0.396\%.
However, the difference in the bias values can be explained if cosmic variance
is taken into account. If such a low halo mass implies a low HI gas mass, this
result appears to be consistent with the observations of a high \lya escape
fraction. With the low halo masses and ongoing star formation, our LAEs have a
relatively high stellar-to-halo mass ratio (SHMR) and a high efficiency of
converting baryons into stars. The extended Press-Schechter formalism predicts
that at z=0z \sim 2$ as some previous
studies have reported for the LMC itself.Comment: 34 pages, 15 figures, 6 tables. Accepted for publication in PAS
The Development of Oral Functions in Children: A Clinical Study of Stomatognathic Dysfunction
In most countries that have reached an aging society, the feeding function among the elderly population has declined and become a serious problem. Therefore, understanding the development of human oral function is required to address this problem. However, only a few research studies have reported oral motor functions and dysfunctions in children. Our chapter describes the relationship between oral motor functions (chewing, swallowing, and breathing) and maxillofacial morphology in children. In addition, case studies on children with cerebral palsy and sleep aspiration disorders will also be introduced. This study would also like to clarify the significance of human oral function development from infancy in pediatric dentistry
Effect of Fe3+ on Phase Relations in the Lower Mantle : Implications for Redox Melting in Stagnant Slabs
Recent studies have revealed that Earth's deep mantle may have a wider range of oxygen fugacities than previously thought. Such a large heterogeneity might be caused by material subducted into the deep mantle. However, high-pressure phase relations are poorly known in systems including Fe3+ at the top of the lower mantle, where the subducted slab may be stagnant. We therefore conducted high-pressure and high-temperature experiments using a multi-anvil apparatus to study the phase relations in a Fe3+-bearing system at 26 GPa and 1573–2073 K, at conditions prevailing at the top of the lower mantle. At temperatures below 1923 K, MgSiO3-rich bridgmanite, an Fe3+-rich oxide phase, and SiO2 coexist in the recovered sample. Quenched partial melt was observed above 1973 K, which is significantly lower than the solidus temperature of an equivalent Fe3+-free bulk composition. The partial melt obtained from the Fe3+-rich bulk composition has a higher iron content than coexisting bridgmanite, similar to the Fe2+-dominant system. The results suggest that strong mantle oxygen fugacity anomalies might alter the subsolidus and melting phase relations under lower mantle conditions. We conclude that (1) a small amount of melt may be generated from an Al-depleted region of a stagnant slab, such as subducted former banded-iron-formation, and (2) Fe3+ is not transported into the deep part of the lower mantle because of its incompatibility during melting
Glutamatergic neurometabolite levels in the caudate are associated with the ability of rhythm production
IntroductionGlutamatergic neurometabolites play important roles in the basal ganglia, a hub of the brain networks involved in musical rhythm processing. We aimed to investigate the relationship between rhythm processing abilities and glutamatergic neurometabolites in the caudate.MethodsWe aquired Glutamatergic function in healthy individuals employing proton magnetic resonance spectroscopy. We targeted the right caudate and the dorsal anterior cingulate cortex (dACC) as a control region. Rhythm processing ability was assessed by the Harvard Beat Assessment Test (H-BAT).ResultsWe found negative correlations between the production part of the Beat Saliency Test in the H-BAT and glutamate and glutamine levels in the caudate (r = −0.693, p = 0.002) whereas there was no such association in the dACC.ConclusionThese results suggest that higher glutamatergic neurometabolite levels in the caudate may contribute to rhythm processing, especially the ability to produce meter in music precisely
- …