Compliance with standards and immerging issues of household sewage disposal systems in Gampaha Municipality Area in Western Sri Lanka

Urban centers are highly significant with limited space together with the rising urban population. Most of the houses and buildings are attached with some kind of a sewage disposal facility as central sewage disposal systems are limited. Urbanization is expected to create many problems in terms of black water disposal due to limitation of land. A study was done in Gampaha municipality area, an urban center, where there is no central sewage treatment facility. The objectives of the study were to analyze the current situation of the black water disposal system in the study area and to identify the shortcomings of the black water disposal system comparing with the standards. The study was conducted within the urban center in five GN divisions. Random samples of 44 households were selected to represent all the five GN divisions. Selected households were interviewed to collect basic data needed and physical measurements were also taken where necessary. The data categories collected are household information, toilet type and size, desludging interval and distance to nearest well. The code of practice for the design and construction of septic tanks reports that 80% of urban communities use septic tanks for sewage disposal, but this study reveals that only 18% of the population uses septic tanks. Over 82% uses typical soakage pits that are constructed with loosely constructed brick walls and bare bottom open to soil for their sewage disposal. Over 68% of the households have their toilet pits within 15m to the nearest well, which is below the recommended distance. Only 30% of the households comply with over 15m to the nearest well that is recommended for septic tanks. The recommended distance for the soakage pits to the nearest well is 30m and only 9% of the households meet this standard. The black water disposal pits are over sized in general, so that the desludging interval is more than 10 years. Recently constructed houses, due to limitation of space, have reduced the size of the pits reducing the size of desludging interval. The construction and placement of septic tanks or soakage pits in the area have not complied with the standards

Determination of Cadmium and Lead in Sewage Sludge from the Middle Region (Misrata, Msallata and Tarhünah Cities) of Libya

The concentrations of cadmium and lead in sewage sludge samples were determined by Atomic Absorption Spectrometric Method. Samples of sewage sludge were obtained from three sewage treatment plants localised in Middle Region of Libya (Misrata, Msallata and Tarhünah cities). The results shows that, the mean levels of Cadmium for all regions are ranges from 81 to 123.4 ppm and these values are higher than the limitations for the international standard which are not registered more than 50 ppm (dry weight) in USA, Egypt and the EU countries. While, the lead concentrations are ranged from 8.0 to 189.2 ppm and all values are within the standard limits which graduated between (275–613) ppm

Bioaccumulation of heavy metals in the selected commercially important edible fish species gray mullet (Mugil cephalus) from Negombo estuary

Consumption of fish contaminated with non essential heavy metals such as Pb, Hg and Cd metals which exceed the required limits pose a risk to human health. Bioaccumulations of heavy metals in fish depend on several factors such as increased levels of industrial pollution and domestic solid waste dumping in the estuary. Based on the pollution inputs into the estuary, it is considered that different localities within the estuary are polluted at different rates.The objectives of this study were to determine the non essential heavy metals concentration in fish tissues and assess the seasonal variations in the ecosystem. For this study, fish tissue samples were collected from nine sampling locations along the North (n =3), South (n=2), West (n=2), and East (n=2) parts of the estuary for a period of one year from January to December 2014. Fish tissue heavy metals levels were analyzed employing standard methods. Results revealed that the average concentrations (mg/kg) varied from Pb 0 to 0.15 ± 0.06, Cd 0.35 ± 0.16 to 1.04 ± 0.28 and Hg 0.0005 ± 0.0004 to 0.05 ± 0.046 mg/kg respectively. The detected levels were below the maximum permissible limits for hazardous substances in fish and fishery products for recommendation of FAO. The detected lead, mercury and cadmium contents in fish tissue were below the standard limits defined for each element < 0.5 mg/kg < 0.05 mg/kg and < 0.05 mg/kg respectively. Significant differences (P < 0.05) were observed for Pb and Hg depending on fish tissues. The levels of Pb and Hg metals in muscle tissue were lower than the standard limit for FAO. The value obtained on Cd 1.04 ± 0.28 mg/kg concentration was much higher than the permissible threshold limit observed in the north, south, east and west regions. The most prominent increases in Pb and Cd metal concentrations in fish tissue were found during the October, November and December study of 2014, which corresponded to peak periods from October, November and December which apparently coincided with the second inter monsoon of the island respectively

Investigation of the Effect Different Antenna parameters (Height, Tilt, and Power) on Network Coverage and System Capacity

The, prospective of radio, mobile network, topology planning, would be to, provide a configuration, that offers the, necessary coverage, several services, as well as, simultaneously, enhances the system, coverage and capacity. This work, addresses the effect, of antenna height, antenna, tilt and  power,  on network, and network capacity. Furthermore, the effects of the above mentioned elements had been investigated using MATLAB program. Appropriately the goal of the actual investigation is always to have because high signal strength as is possible in the area in which the cell ought to be serving  traffic. Beyond the particular serving part of the cell, typically the signal power should be low so as to fight the problem associated with fluctuation within received sign strength through the mobile customers in a cellular. Results of often the investigation display that greatest coverage is actually obtained in 38m elevation, 46dB strength and 2° tilt

The Electrophysiological Perspectives of Essential, Enhanced Physiological, and Physiological Tremors

Abstract: Background: The most frequent movement issue seen in clinical practice is tremors. It is known as repetitive, involuntary oscillations. The diagnostic process for tremor patients can be time-consuming and complicated, as the identification of “Essential Tremor” and its distinction from other types of tremor. Objectives: This study aimed to describe the electrophysiological findings of essential, enhanced physiological, and physiological tremors, using surface electromyography and an accelerometer. Patients and Methods: The study included 24 patients with essential tremors, 10 patients with enhanced physiological tremors, and 10 patients with physiological tremors. We assessed the frequency, amplitude, and muscular contraction pattern of tremors during rest, posture, and a 1 kg load.  Results: The tremor frequency of essential tremor patients was about 4.2-10.1 Hertz, while enhanced physiological tremor and physiological tremor were increased to 6.1–12.7 Hertz and 5.1-10.2 Hertz, respectively. The essential tremor group muscle contraction pattern was predominantly synchronous, as do all enhanced physiological, and physiological tremor patients, but with more fine low amplitude muscle bursts. By varying the tremor frequency and the weight load effect, tremor analysis could discriminate essential from enhanced physiological, and physiological tremors. Conclusions: The tremor analysis using surface electromyography and an accelerometer is sufficient to differentiate between essential tremors, enhanced physiological tremors, and physiological tremors.

Self-Compacting Concrete Reinforced with Steel Fibers from Scrap Tires: Rheological and Mechanical Properties

The aim of this study is to evaluate the rheological behavior and the mechanical performance of SCC with different contents and lengths of recycled steel fiber (RSF) recovered from scrap tires. The rheological properties investigated in this study include: slump flow, J-ring, L-box, and V-funnel tests. The mechanical properties include: compressive and flexural strength. The parameters of the study are fiber content and length. In total, thirteen self-compacting concrete (SCC) mixtures were prepared. Three fibers contents 30, 60 and 90 kg/m3 were investigated and for each fiber contents Wf , four mixes were prepared with four different fiber lengths (Lf) (10, 15, 25, 35 mm). A control mix (plain SCC) was also prepared for comparison reasons. The results showed that the addition of RSF decreased the slump flow, slowed down the flow rate and increased the V-funnel time but maintained the requirement of SCC up to 60 kg/m3 fiber content. Shorter fibers had less effect on the rheological behavior of SCC than long fibers. Both RSF content and length affected the compressive strength and the flexural strength of SCC. Long RSF reduced compressive strength but increased the flexural strength

Methylation-Specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences

Copy number changes and CpG methylation of various genes are hallmarks of tumor development but are not yet widely used in diagnostic settings. The recently developed multiplex ligation-dependent probe amplification (MLPA) method has increased the possibilities for multiplex detection of gene copy number aberrations in a routine laboratory. Here we describe a novel robust method: the methylation-specific MLPA (MS-MLPA) that can detect changes in both CpG methylation as well as copy number of up to 40 chromosomal sequences in a simple reaction. In MS-MLPA, the ligation of MLPA probe oligonucleotides is combined with digestion of the genomic DNA–probe hybrid complexes with methylation-sensitive endonucleases. Digestion of the genomic DNA–probe complex, rather than double-stranded genomic DNA, allowed the use of DNA derived from the formalin treated paraffin-embedded tissue samples, enabling retrospective studies. To validate this novel method, we used MS-MLPA to detect aberrant methylation in DNA samples of patients with Prader–Willy syndrome, Angelman syndrome or acute myeloid leukemia

Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): a randomised, double-blind, placebo-controlled trial

Background Many patients with type 2 diabetes do not achieve sustained diabetes remission after metabolic (bariatric) surgery for the treatment of obesity. Liraglutide, a glucagon-like peptide-1 analogue, improves glycaemic control and reduces bodyweight in patients with type 2 diabetes. Our aim was to assess the safety and efficacy of liraglutide 1·8 mg in patients with persistent or recurrent type 2 diabetes after metabolic surgery. Methods In the GRAVITAS randomised double-blind, placebo-controlled trial, we enrolled adults who had undergone Roux-en-Y gastric bypass or vertical sleeve gastrectomy and had persistent or recurrent type 2 diabetes with HbA1c levels higher than 48 mmol/mol (6·5%) at least 1 year after surgery from five hospitals in London, UK. Participants were randomly assigned (2:1) via a computer-generated sequence to either subcutaneous liraglutide 1·8 mg once daily or placebo, both given together with a reduced-calorie diet, aiming for a 500 kcal per day deficit from baseline energy intake, and increased physical activity. The primary outcome was the change in HbA1c from baseline to the end of the study period at 26 weeks, assessed in patients who completed the trial. Safety was assessed in the safety analysis population, consisting of all participants who received either liraglutide or placebo. This trial is registered with EudraCT, number 2014-003923-23, and the ISRCTN registry, number ISRCTN13643081. Findings Between Jan 29, 2016, and May 2, 2018, we assigned 80 patients to receive either liraglutide (n=53) or placebo (n=27). 71 (89%) participants completed the study and were included in the principal complete-cases analysis. In a multivariable linear regression analysis, with baseline HbA1c levels and surgery type as covariates, liraglutide treatment was associated with a difference of −13·3 mmol/mol (−1·22%, 95% CI −19·7 to −7·0; p=0·0001) in HbA1c change from baseline to 26 weeks, compared with placebo. Type of surgery had no significant effect on the outcome. 24 (45%) of 53 patients assigned to liraglutide and 11 (41%) of 27 assigned to placebo reported adverse effects: these were mainly gastrointestinal and in line with previous experience with liraglutide. There was one death during the study in a patient assigned to the placebo group, which was considered unrelated to study treatment. Interpretation These findings support the use of adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery

The sub-seasonal to seasonal prediction (S2S) project database

A database containing sub-seasonal to seasonal forecasts from 11 operational centres is available to the research community and will help advance our understanding of the sub-seasonal to seasonal time range. Demands are growing rapidly in the operational prediction and applications communities for forecasts that fill the gap between medium-range weather and long-range or seasonal forecasts. Based on the potential for improved forecast skill at the sub-seasonal to seasonal time range, a sub-seasonal prediction (S2S) research project has been established by the World Weather Research Program/World Climate Research Program. A main deliverable of this project is the establishment of an extensive database, containing sub-seasonal (up to 60 days) forecasts, 3-weeks behind real-time, and reforecasts from 11 operational centers, modelled in part on the THORPEX Interactive Grand Global Ensemble (TIGGE) database for medium range forecasts (up to 15 days). The S2S database, available to the research community since May 2015, represents an important tool to advance our understanding of the sub-seasonal to seasonal time range that has been considered for a long time as a “desert of predictability”. In particular, this database will help identify common successes and shortcomings in the model simulation and prediction of sources of sub-seasonal to seasonal predictability. For instance, a preliminary study suggests that the S2S models underestimate significantly the amplitude of the Madden Julian Oscillation (MJO) teleconnections over the Euro-Atlantic sector. The S2S database represents also an important tool for case studies of extreme events. For instance, a multi-model combination of S2S models displays higher probability of a landfall over Vanuatu islands 2 to 3 weeks before tropical cyclone Pam devastated the islands in March 2015