16 research outputs found
Identification of minimal sequence for HIV-1 fusion inhibitors.
Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to the previously reported inhibitor SC35EK. Some residues in SC29EK not required for interaction with virus gp41 heptad repeat 1 (HR1) were replaced with a non-proteinogenic amino acid, 2-aminoisobutyric acid (Aib), to stabilize the alpha-helix structure and to provide resistance to peptidases
A comparison of the diagnostic efficacy in type 1 autoimmune pancreatitis based on biopsy specimens from various organs
Tu1804 Which Is the Better Procedure for the Closure of Diverting Loop Ileostomy After Ileal Pouch Anal Anastomosis for Ulcerative Colitis; Stapled or Hand-Sewn Anastomosis?
Formation of [2]- and [3]Rotaxanes through Bridging under Kinetic and Thermodynamic Control
An
efficient synthesis of a doubly stranded [3]rotaxane has been
developed through bridging of a pseudo[3]rotaxane featuring two axle
components. Reversible azine formation was effective as the bridging
reaction. Kinetic and thermodynamic conditions provided the [2]- and
[3]rotaxanes, respectively