111 research outputs found

    Ecosystem Services for Disaster Risk Reduction: A Case Study of Wetland in East Delhi Region, India

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    Ecosystem services are the benefits that societies receive from the nature These may be in the form of regulating provisioning supporting or cultural services Wetland being one of the most productive ecosystems provides these services at no cost These ecosystems also contribute to reducing disaster risk by serving as natural protective barriers or buffers and thus mitigating hazard impacts But many such wetland ecosystems are tremendous stressed due to anthropogenic pressure Wetlands on the fringes of river channels in the city are looked upon as a resource for different land use planning The capital Delhi manifests all the ills that a river system Yamuna can possibly face made the city more vulnerable and disaster prone as evident from frequent incidences of flood water crisis and disease outbreak Rapidly increasing urbanisation with limited integration of values and functions of floodplains in developmental planning has led to their fragmentation This study is an attempt to assess the present state of ecosystems its services particularly in reducing the risk of water and climate related disasters like flood drought and epidemics in East Delhi and part of National Capital Refio

    Dealing with the Likelihood of Failure over the Long-Term: Adaptive Policy Design under Uncertainty

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    10.2139/ssrn.23943481-2

    Rapidly Convergent Series from Positive Term Series

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    In this paper we shall give description about the extraction of a rapidly decaying remainder from Euler series and telescoping series. Then we apply the procedure to generalised telescoping series. The new positive term series obtained with rapidly decaying remainder will converge faster than the original series. We shall apply the procedure to generalised telescoping series also. The introduction of such remainder will give a better approximation for the series

    Évaluation de l'outil CEC (Correct Eventual Consistency) pour la vérification des applications à cohérence à terme

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    Preserving invariants while designing distributed applications under weak consistency models is difficult. The CEC (Correct Eventual Consistency Tool) is meant to aid the application designer in this task. This report presents some specifications tried out using the tool and some recommendations for its improvement based on the usage experience.Le maintien des invariants, dans les applications réparties s'exécutantdans un modèle de cohérence faible, est un problème difficile.L'outil CEC (Correct Eventual Consistency) est destiné à aider ledéveloppeur d'application dans cette tâche.Notre rapport présente plusieurs exemples de spécifications vérifiées enutilisant cet outil, ainsi que quelques recommandations sur son usage,basées sur notre expérience d'utilisation

    Invariant Safety for Distributed Applications

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    We study a proof methodology for verifying the safety of data invariants of highly-available distributed applications that replicate state. The proof is (1) modular: one can reason about each individual operation separately, and (2) sequential: one can reason about a distributed application as if it were sequential. We automate the methodology and illustrate the use of the tool with a representative example.Comment: Workshop on Principles and Practice of Consistency for Distributed Data (PaPoC), Mar 2019, Dresden, Germany. https://novasys.di.fct.unl.pt/conferences/papoc19

    ANTIEPILEPTIC RECTAL HYDROGEL LOADED WITH CARBAMAZEPINE – RICE BRAN WAX MICROSPHERES

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    ABSTRACTObjectives: The objective behind the study is to develop a mucoadhesive rectal hydrogel from carbamazepine (CBZ) – rice bran wax (RBW)microspheres for the purpose of controlled release for the treatment of epilepsy.Methods: The study was conducted to formulate controlled release rectal hydrogel loaded with CBZ – RBW microspheres in two different natural polymers,RBW and collagen which are prepared by modified cooling induced solidification method and gel preparation along with their evaluation studies.Results: A thorough analysis of the optimized gel revealed that all the evaluation parameters evaluated are within the acceptable limits. Further, theoptimized microsphere formulation (M5) was used to formulate it as rectal hydrogel using polymer collagen and was characterized. The mucoadhesiontime of 25% w/w collagen hydrogel (H4) was 565 minutes, allowing the loaded microspheres to be attached on rectal mucosa. In vitro drug releasefrom the mucoadhesive hydrogel formulations showed controlled drug release pattern with a maximum drug release of 96.45±0.35% for optimizedH4 formulation after 12 hr, followed zero order release pattern with diffusion mediated Higuchi model. Ex vivo permeation studies using bovine rectalmucosa revealed that H4 formulation showed greater permeability compared to control. Histopathological findings revealed that H4 formulation issafer for rectal administration without any signs of rectal irritancy. The stability studies of optimized formulation (H4) proved that hydrogel remainedstable over a wide range of temperature condition.Conclusion: Hence, the developed rectal hydrogel formulation seems to be a viable alternative to conventional drug delivery system for the effectivemanagement of epilepsy.Keywords: Carbamazepine, Rice bran wax, Rectal hydrogel, Sustainability

    Association of PPARα Intron 7 Polymorphism with Coronary Artery Disease: A Cross-Sectional Study

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    The allelic variants of peroxisome proliferator-activated receptor alpha (PPARα) can influence the risk of coronary artery disease (CAD) by virtue of its effect on lipid metabolism. However, the role of PPARα intronic polymorphism with CAD has received little attention. The association of allelic variants G/C at intron 7 of the PPAR-alpha gene with CAD was examined in a hospital-based Indian population. PPAR genotyping was performed in 110 male patients with CAD and 120 age and ethnically matched healthy males by PCR amplification of the gene followed by restriction digestion. Presence of C allele showed a positive association with CAD (OR = 2.9; 95% CI [1.65–4.145]; P = .009) and also with dyslipidaemia (OR = 2.95, 95% CI (1.5–4.39); P < .05). Impaired lipid metabolism in carriers of the PPARα Intron 7C allele is possibly responsible for the predilection to CAD

    “Push” dynamics in policy experimentation: Downscaling climate change adaptation programs in Canada

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    Policy experiments have often been touted as valuable mechanisms for ensuring sustainability transitions and climate change adaptation. However problems exist both in the definition of ‘experiments’, and in their design and realization. While valuable, most experiments examined in the literature to date have been small-scale micro-level deployments or evaluations of policy tools in which the most problematic element revolves around their “scaling-up” or diffusion. The literature on the subject has generally neglected the problems and issues related to another class of experiments in which macro or meso-level initiatives are ‘scaled-down’ to the micro-level. This paper examines a recent effort of this kind in Canada involving the creation of Regional Adaptation Collaboratives (RACs) across the country whose main purpose is to push national level initiatives down to the regions and localities. As the discussion shows, this top-down process has its own dynamics distinct from those involved in ‘scaling up’ and should be examined as a separate category of policy experiments in its own right
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