Patient-reported outcomes 6 months after enhanced recovery after colorectal surgery.

BackgroundEnhanced recovery after surgery (ERAS) programs have been established as perioperative strategies associated with improved outcomes. However, intermediate and long-term patient-reported outcome data for patients undergoing ERAS interventions remain limited. We utilized an automated telephone survey 6 months post-colorectal surgery from patients who participated in an ERAS program to determine 6-month patient-reported outcomes and associated predictive factors.MethodsWe conducted a prospective observational study, using an automated telephone survey and researcher-administered telephone questionnaire 6 months after patients underwent abdominal colorectal surgery. Six-month significant outcomes were defined by persistent pain, hospital readmission, and patient satisfaction. Patients reporting these outcome variables were compared with patients who met none of these criteria. Additionally, analysis was performed to determine differences between patients that did and did not respond to the 6-month survey. A chi-square test was used to determine any relationship for categorical variables, a two independent sample t test for length of procedure/stay, and a Wilcoxon-Mann-Whitney test for pain scores.ResultsOne hundred fifty-four of 324 patients contacted 6 months after surgery completed the automated telephone survey (47.53%). There was no statistical difference between patient populations completing and not completing the survey. Hospital 6-month readmission was associated with patients with a diagnosis of cancer (P = .049) and with a longer mean length of index procedure (282 vs. 206 minutes, P = .006). Median 6-month pain scores were higher for patients that underwent an open procedure compared to laparoscopic (Z = - 2.06, P = .04).ConclusionsLong-term benefits of an ERAS program were mostly confirmed. Longer procedure time and patients with cancer correlated with an increased likelihood of hospital 6-month readmission, suggesting that perioperative outcomes in complex cancer patients need to be evaluated over a longer time frame. In addition, invasiveness of procedure continues to have a significant effect on pain scores even 6 months later

Toxic Comment Classification using Deep Learning

Online Conversation media serves as a means for individuals to engage, cooperate, and exchange ideas; however, it is also considered a platform that facilitates the spread of hateful and offensive comments, which could significantly impact one's emotional and mental health. The rapid growth of online communication makes it impractical to manually identify and filter out hateful tweets. Consequently, there is a pressing need for a method or strategy to eliminate toxic and abusive comments and ensure the safety and cleanliness of social media platforms. Utilizing LSTM, Character-level CNN, Word-level CNN, and Hybrid model (LSTM + CNN) in this toxicity analysis is to classify comments and identify the different types of toxic classes by means of a comparative analysis of various models. The neural network models utilized for this analysis take in comments extracted from online platforms, including both toxic and non-toxic comments. The results of this study can contribute towards the development of a web interface that enables the identification of toxic and hateful comments within a given sentence or phrase, and categorizes them into their respective toxicity classes

Interventional Spine and Pain Procedure Credentialing: Guidelines from the American Society of Pain & Neuroscience

Background: The discipline of interventional pain management has changed significantly over the past decade with an expected greater evolution in the next decade. Not only have the number of procedures increased, some of the procedures that were created for spine surgeons are becoming more facile in the hands of the interventional pain physician. Such change has outpaced academic institutions, societies, and boards. When a pain physician is in the credentialing process for novel procedure privileges, it can leave the healthcare system in a challenging situation with little to base their decision upon. Methods: This paper was developed by a consensus working group from the American Society of Pain and Neuroscience from various disciplines. The goal was to develop processes and resources to aid in the credentialing process. Results: These guidelines from the American Society of Pain and Neuroscience provide background information to help facilities create a process to appropriately credential physicians on novel procedures. They are not intended to serve as a standard or legal precedent. Conclusion: This paper serves as a guide for facilities to credential physicians on novel procedures

Patient-reported outcomes 6 months after enhanced recovery after colorectal surgery.

BackgroundEnhanced recovery after surgery (ERAS) programs have been established as perioperative strategies associated with improved outcomes. However, intermediate and long-term patient-reported outcome data for patients undergoing ERAS interventions remain limited. We utilized an automated telephone survey 6 months post-colorectal surgery from patients who participated in an ERAS program to determine 6-month patient-reported outcomes and associated predictive factors.MethodsWe conducted a prospective observational study, using an automated telephone survey and researcher-administered telephone questionnaire 6 months after patients underwent abdominal colorectal surgery. Six-month significant outcomes were defined by persistent pain, hospital readmission, and patient satisfaction. Patients reporting these outcome variables were compared with patients who met none of these criteria. Additionally, analysis was performed to determine differences between patients that did and did not respond to the 6-month survey. A chi-square test was used to determine any relationship for categorical variables, a two independent sample t test for length of procedure/stay, and a Wilcoxon-Mann-Whitney test for pain scores.ResultsOne hundred fifty-four of 324 patients contacted 6 months after surgery completed the automated telephone survey (47.53%). There was no statistical difference between patient populations completing and not completing the survey. Hospital 6-month readmission was associated with patients with a diagnosis of cancer (P = .049) and with a longer mean length of index procedure (282 vs. 206 minutes, P = .006). Median 6-month pain scores were higher for patients that underwent an open procedure compared to laparoscopic (Z = - 2.06, P = .04).ConclusionsLong-term benefits of an ERAS program were mostly confirmed. Longer procedure time and patients with cancer correlated with an increased likelihood of hospital 6-month readmission, suggesting that perioperative outcomes in complex cancer patients need to be evaluated over a longer time frame. In addition, invasiveness of procedure continues to have a significant effect on pain scores even 6 months later

Planetary Waves at Equatorial Stratopause

279-280The rocketsonde meteorological data for the Thumba equatorial station are examined to study wave periods of planetary wave disturbances at stratopause. The temperature, density and the height data obtained every Wednesday; regularly over the period 1972-74 are used to identify the stratopause. Power spectral analysis of the stratopause height and density is carried out. Dominant peaks in spectral power are observed at periods of 20 and 40 days

Impact of Nanoscale Zinc Oxide Particle on the Growth, Yield and Soil Properties under Agency Area of Andhra Pradesh

Field experiment was carried out on silt clay loam soils at Regional Agricultural Research station, Chintapalle, Visakhapatnam, Andhra Pradesh during 2018-2020 to study the yield of response of rainfed groundnut with different levels of Nano particulate zinc oxide application along with NPK Fertilizers. The experiment consisting of eight treatments, three replications with RDF design. Results of nano  particulate zinc oxide on pod yield showed that (24.36 Q/ha) in the RDF+ nano scale zinc oxide level @  200 ppm at 25 and 45 DAS was increased over to that of normal recommended dose of N,P,K fertilizers (100% RDF) which recorded pod yield of 17.14  Q/ha only. Application of ZnSO4 through soil along with RDF showed good results (17.24 Q/ha) than RDF + Foliar application of ZnSO4 @ 2g/lit at 25 and 45 DAS (20.66 Q/ha). Application of micronutrient (ZnO) had helped in further increase in grain yields at both levels of ZnO (150% and 200% ZnO at 25 and 45 DAS). Among different treatments, significantly higher yield (24.36 Q/ha) was recorded with application of RDF + Foliar application of ZnO @ 200 ppm at 25 and 45 DAS than the only with RDF (17.4 Q/ha). With respect to method of application of ZnSO4 through soil and foliar application ZnSo4 @ 2g/lit at 25 and 45 DAS was found to be higher both levels of RDF (Pod yield of 14.6 Q/ha at RDF + Soil application of ZnSO4 @ 50 kg ha-1 and 17.24 Q/ha at RDF+ foliar application of ZnSO4@ 2g/lit at 25 and 45 DAS). With respect to other plant characteristics, comparatively more plant height (43.53 cm) at RDF + foliar application of ZnO @ 200 ppm at 25 and 45 DAS. Regarding yield attributes significantly higher test weight (30.9 g) were recorded at RDF + 200 ppm ZnO at 25 and 45 DAS. Post –harvest soil sample analysis showed highest availability of nutrients in respect of soil, the results revealed that there was no significance difference among the treatments regarding Avail. N, Available K and pH. The lowest Phosphorus (17.20 kg ha-1) was recorded with RDF+  Foliar application of  nanoscale ZnO  200 ppm at 25 & 45 DAS and highest (24.46 kg ha-1) was recorded in T9 (RDF+  Foliar application of  nanoscale ZnO  100 ppm at 25 & 45 DAS).                  An investigation was initiated at Department of Soil science, Regional Agricultural Research Station, Chintapalle to examine the effects of nano zinc oxide on Groundnut (Arachis hypogea L.) growth, yield and Zn content in Leaves, stem and roots. A field experiment consisted of nine treatments comprised of T1: control, T2: RDF, T3: RDF+ Soil application ZnSO4@ 50 Kg/ha, T4: RDF+ Foliar application ZnSO4 2 g/L at 25 & 45DAS, T5: RDF+ Foliar application of  nanoscale ZnO  150 ppm at 25 & 45 DAS, T6: RDF+  Foliar application of  nanoscale ZnO  200 ppm at 25 & 45 DAS, T7: RDF+  Foliar application of  nanoscale ZnO  400 ppm at 25 & 45 DAS, T8: RDF+  Foliar application of  nanoscale ZnO  50 ppm at 25 & 45 DAS, T9: RDF+  Foliar application of  nanoscale ZnO  100 ppm at 25 & 45 DAS

Green and efficient synthesis of 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydropthalazine-1,4-dione

412-4172-Hydrazinoquinazolin-3H-4-ones 1a,b were reacts with each of the anhydrides, phthalic anhydride 2a, succinic anhydride 2b and maleic anhydride 2c independently in PEG-600 at RT to yield 2-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazine-ecarbonyl)benzoic acid 3a,b, 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)butanoic acid 3c,d and 4-oxo-4-(2-(4-oxo-3,4-dihydroquinazolin-2-yl)hydrazinyl)but-2-enoic acid 3e,f, respectively. 3a,b,<b style="mso-bidi-font-weight: normal"> 3c,d, 3e,f have been transformed into 2-(4-oxo-3,4-dihydroquinazolin-2-yl)-2,3-dihydrophthalazine-1,4-dione 4a,b, 1-(4-oxo-3,4-dihydroquinazolin-2-yl)piperazine-3,6-dione 4c,d and 1-(4-oxo-3,4-dihydroquinazolin-2-yl)-1,2-dihydropyridazine-3,6-dione 4e,f, respectively by heating each in PEG-600 at 100 °C for 3-3.5 hr in high yields and in high purity, involving a dehydrative ring closure. The final compounds <b style="mso-bidi-font-weight: normal">4a-f have also been prepared alternatively by reacting 1 with <b style="mso-bidi-font-weight: normal">2 in PEG-600 at 100 °C for 3.5-4 hr

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial

Rationale. Bacopa monnieri, popularly known as Brahmi, has been traditionally used in Ayurveda since ages for its memory enhancing properties. However, data on placebo-controlled trial of Bacopa monnieri on intellectual sample is scarce. Hence this study was planned to evaluate the effect of Bacopa monnieri on memory of medical students for six weeks. Objective. To evaluate the efficacy of Bacopa monnieri on memory of medical students with six weeks’ administration. Method and Material. This was a randomized double blind placebo-controlled noncrossover, parallel trial. Sixty medical students of either gender from second year of medical school, third term, regular batch, were enrolled from Government Medical College, Nagpur, India. Baseline biochemical and memory tests were done. The participants were randomly divided in two groups to receive either 150 mg of standardized extract of Bacopa monnieri (Bacognize) or matching placebo twice daily for six weeks. All baseline investigations were repeated at the end of the trial. Students were followed up for 15 days after the intervention. Results. Statistically significant improvement was seen in the tests relating to the cognitive functions with use of Bacopa monnieri. Blood biochemistry also showed a significant increase in serum calcium levels (still within normal range)

Exploring the Benefits of Rice Husk Waste: Synthesis and Characterization of Biochar and Nanobiochar for Agricultural and Environmental Sustainability

Rice husk waste is a significant byproduct of rice production in developing countries, with a vast annual production. This waste material has been extensively used as an adsorbent for various substances due to its adsorption capabilities. Biochar, a carbon-rich material produced through pyrolysis of biomass, has gained attention for its diverse applications in agriculture and the environment. In this study, rice husk biochar and nanobiochar were synthesized and characterized to explore their potential benefits for agricultural and environmental sustainability. The biochar was prepared by pyrolysis of rice husk at 500°C in a low-oxygen environment, followed by grinding and sieving. Nanobiochar was obtained by ball milling the biochar particles. The physical and physicochemical properties of both biochar and nanobiochar were evaluated, including bulk density (0.41 and 0.59 Mg m-3), particle density (0.49 and 0.54 Mg m-3), water holding capacity (168.6 and 178.5%), pH (8.4 and 7.3), electrical conductivity (0.31 and 0.45 dS m-1), cation exchange capacity (26.3 and 24.1cmol (p+) kg-1), volatile matter content (21.91 and 18.90%) and particle size distribution. Spectral analysis techniques such as DLS, FTIR, XRD, SEM and EDX were used to examine the size, zeta potential functional groups, crystallinity, porosity and elemental composition of the samples. The results showed that nanobiochar exhibited improved physical characteristics, such as higher porosity and water retention capacity, compared to biochar. The elemental composition and volatile matter content differed between the two materials. Nanobiochar also had significantly smaller particle size (11 nm) and a stable zeta potential. These findings suggest that rice husk nanobiochar has great potential for applications in soil fertility enhancement, adsorption of contaminants and waste management. The study contributes to the understanding of the properties and applications of rice husk waste-derived biochar and nanobiochar, promoting their utilization for sustainable agricultural and environmental practices