23 research outputs found
Detection of 15 bursts from FRB 180916.J0158+65 with the uGMRT
We report the findings of a uGMRT observing campaign on FRB 180916.J0158+65,
discovered recently to show a 16.35-day periodicity of its active cycle. We
observed the source at 550-750 MHz for hours each during three
successive cycles at the peak of its expected active period. We find 0, 12, and
3 bursts respectively, implying a highly variable bursting rate even within the
active phase. We consistently detect faint bursts with spectral energies only
an order of magnitude higher than the Galactic burst source SGR~1935+2154. The
times of arrival of the detected bursts rule out many possible aliased
solutions, strengthening the findings of the 16.35-day periodicity. A
short-timescale periodicity search returned no highly significant candidates.
Two of the beamformer-detected bursts were bright enough to be clearly detected
in the imaging data, achieving sub-arcsecond localization, and proving as a
proof-of-concept for FRB imaging with the GMRT. We provide a upper
limit of the persistent radio flux density at 650 MHz of
which, combined with the EVN and VLA limits at 1.6~GHz, further constrains any
potential radio counterpart. These results demonstrate the power of uGMRT for
targeted observations to detect and localize known repeating FRBs.Comment: 5 pages, 4 figures, accepted for publication in MNRAS Letter
The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India
IntroductionAlthough excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed to assess the impact of the use of PPE on the minimization of effects of exposure to pesticides among farm-workers.MethodsA community-based follow-up study with questionnaire-based survey and field observations was undertaken among farm-workers (n = 180) of Rangareddy district, Telangana, India. Biomarkers of exposure such as cholinesterase activity, inflammatory markers (TNF-α, IL-1β, IL-6, cortisol, and hs-C reactive protein), nutrients (vitamins A, E), liver function (total protein and A/G ratio, AST and ALT levels) were investigated in the laboratory by following the standard protocols.ResultsFarm-workers who had a mean farming exposure of 18 years of and who neither followed safe pesticide handling practices nor used PPE and also showed reluctance to obey good agricultural practices (GAPs). Inhibition of AChE (acetylcholine esterase) with increased inflammation was found among farm-workers as compared to their respective normal values when they have not used PPE. Linear regression statistical analysis revealed a profound effect on inhibition in the AChE activity and various inflammatory markers with the increase in the duration of pesticide exposure. Further, there was no effect of the duration of pesticide exposure on the levels of vitamins A, E, ALT, AST, total protein, and A/G ratio. Further, intervention studies carried out on the use of PPE provided (commercially available and cost-effective) for 90 days showed a significant reduction in the biomarker levels (p < 0.01).ConclusionThis study demonstrated the importance of the use of PPE during pesticide applications and other agricultural tasks to minimize pesticide-associated adverse health effects
High Precision Measurements of Interstellar Dispersion Measure with the upgraded GMRT
Pulsar radio emission undergoes dispersion due to the presence of free
electrons in the interstellar medium (ISM). The dispersive delay in the arrival
time of pulsar signal changes over time due to the varying ISM electron column
density along the line of sight. Correcting for this delay accurately is
crucial for the detection of nanohertz gravitational waves using Pulsar Timing
Arrays. In this work, we present in-band and inter-band DM estimates of four
pulsars observed with uGMRT over the timescale of a year using two different
template alignment methods. The DMs obtained using both these methods show only
subtle differences for PSR 1713+0747 and J19093744. A considerable offset is
seen in the DM of PSR J1939+2134 and J21450750 between the two methods. This
could be due to the presence of scattering in the former and profile evolution
in the latter. We find that both methods are useful but could have a systematic
offset between the DMs obtained. Irrespective of the template alignment methods
followed, the precision on the DMs obtained is about pc cm
using only BAND3 and pc cm after combining data from BAND3 and
BAND5 of the uGMRT. In a particular result, we have detected a DM excess of
about pc cm on 24 February 2019 for PSR J21450750.
This excess appears to be due to the interaction region created by fast solar
wind from a coronal hole and a coronal mass ejection (CME) observed from the
Sun on that epoch. A detailed analysis of this interesting event is presented.Comment: 11 pages, 6 figures, 2 tables. Accepted by A&
Epidemiology and outcome of an acute kidney injuries in the polytrauma victims admitted at the apex trauma center in Dubai
Background Polytrauma from road accidents is a common cause of hospital admissions and deaths, frequently leading to acute kidney injury (AKI) and impacting patient outcomes. Methods This retrospective, single-center study included polytrauma victims with an Injury Severity Score (ISS) >25 at a tertiary healthcare center in Dubai. Results The incidence of AKI in polytrauma victims is 30.5%, associated with higher Carlson comorbidity index (P=0.021) and ISS (P=0.001). Logistic regression shows a significant relationship between ISS and AKI (odds ratio [OR], 1.191; 95% confidence interval [CI], 1.150–1.233; P<0.05). The main causes of trauma-induced AKI are hemorrhagic shock (P=0.001), need for massive transfusion (P<0.001), rhabdomyolysis (P=0.001), and abdominal compartment syndrome (ACS; P<0.001). On multivariate logistic regression AKI can be predicated by higher ISS (OR, 1.08; 95% CI, 1.00–1.17; P=0.05) and low mixed venous oxygen saturation (OR, 1.13; 95% CI, 1.05–1.22; P<0.001). The development of AKI after polytrauma increases length of stay (LOS)-hospital (P=0.006), LOS-intensive care unit (ICU; P=0.003), need for mechanical ventilation (MV) (P<0.001), ventilator days (P=0.001), and mortality (P<0.001). Conclusions After polytrauma, the occurrence of AKI leads to prolonged hospital and ICU stays, increased need for mechanical ventilation, more ventilator days, and a higher mortality rate. AKI could significantly impact their prognosis
Diffusion tensor imaging in evaluation of posterior fossa tumors in children on a 3T MRI scanner
Context: Primary intracranial tumors in children are commonly located in the posterior fossa. Conventional MRI offers limited information regarding the histopathological type of tumor which is essential for better patient management. Aims: The purpose of the study was to evaluate the usefulness of advanced MR imaging techniques like diffusion tensor imaging (DTI) in distinguishing the various histopathological types of posterior fossa tumors in children. Settings and Design: DTI was performed on a 3T MRI scanner in 34 untreated children found to have posterior fossa lesions. Materials and Methods: Using third party software, various DTI parameters [apparent diffusion coefficient (ADC), fractional anisotropy (FA), radial diffusivity, planar index, spherical index, and linear index] were calculated for the lesion. Statistical Analysis Used: Data were subjected to statistical analysis [analysis of variance (ANOVA)] using SPSS 15.0 software. Results: We observed significant correlation (P < 0.01) between ADC mean and maximum, followed by radial diffusivity (RD) with the histopathological types of the lesions. Rest of the DTI parameters did not show any significant correlation in our study. Conclusions: The results of our study support the hypothesis that most cellular tumors and those with greater nuclear area like medulloblastoma would have the lowest ADC values, as compared to less cellular tumors like pilocytic astrocytoma
Polyhydroxy-<i>N</i>-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential
<p></p> <p>A focused library of novel <i>N</i>-alkyl-2-pyrrolidinone derivatives <b>3a–e</b> was synthesized from d-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.</p
Data_Sheet_1_The impact of the use of personal-protective-equipment on the minimization of effects of exposure to pesticides among farm-workers in India.PDF
IntroductionAlthough excessive use of pesticides and unsafe agricultural practices may contribute to numerous intoxications, the role of PPE (personal-protective-equipment) in the minimization of toxicological effects due to pesticide exposure has not been addressed so far. The present study aimed to assess the impact of the use of PPE on the minimization of effects of exposure to pesticides among farm-workers.MethodsA community-based follow-up study with questionnaire-based survey and field observations was undertaken among farm-workers (n = 180) of Rangareddy district, Telangana, India. Biomarkers of exposure such as cholinesterase activity, inflammatory markers (TNF-α, IL-1β, IL-6, cortisol, and hs-C reactive protein), nutrients (vitamins A, E), liver function (total protein and A/G ratio, AST and ALT levels) were investigated in the laboratory by following the standard protocols.ResultsFarm-workers who had a mean farming exposure of 18 years of and who neither followed safe pesticide handling practices nor used PPE and also showed reluctance to obey good agricultural practices (GAPs). Inhibition of AChE (acetylcholine esterase) with increased inflammation was found among farm-workers as compared to their respective normal values when they have not used PPE. Linear regression statistical analysis revealed a profound effect on inhibition in the AChE activity and various inflammatory markers with the increase in the duration of pesticide exposure. Further, there was no effect of the duration of pesticide exposure on the levels of vitamins A, E, ALT, AST, total protein, and A/G ratio. Further, intervention studies carried out on the use of PPE provided (commercially available and cost-effective) for 90 days showed a significant reduction in the biomarker levels (p ConclusionThis study demonstrated the importance of the use of PPE during pesticide applications and other agricultural tasks to minimize pesticide-associated adverse health effects.</p
Analytical validation of CanAssist-Breast: an immunohistochemistry based prognostic test for hormone receptor positive breast cancer patients
Abstract Background CanAssist-Breast is an immunohistochemistry based test that predicts risk of distant recurrence in early-stage hormone receptor positive breast cancer patients within first five years of diagnosis. Immunohistochemistry gradings for 5 biomarkers (CD44, ABCC4, ABCC11, N-Cadherin and pan-Cadherins) and 3 clinical parameters (tumor size, tumor grade and node status) of 298 patient cohort were used to develop a machine learning based statistical algorithm. The algorithm generates a risk score based on which patients are stratified into two groups, low- or high-risk for recurrence. The aim of the current study is to demonstrate the analytical performance with respect to repeatability and reproducibility of CanAssist-Breast. Methods All potential sources of variation in CanAssist-Breast testing involving operator, run and observer that could affect the immunohistochemistry performance were tested using appropriate statistical analysis methods for each of the CanAssist-Breast biomarkers using a total 309 samples. The cumulative effect of these variations in the immunohistochemistry gradings on the generation of CanAssist-Breast risk score and risk category were also evaluated. Intra-class Correlation Coefficient, Bland Altman plots and pair-wise agreement were performed to establish concordance on IHC gradings, risk score and risk categorization respectively. Results CanAssist-Breast test exhibited high levels of concordance on immunohistochemistry gradings for all biomarkers with Intra-class Correlation Coefficient of ≥0.75 across all reproducibility and repeatability experiments. Bland-Altman plots demonstrated that agreement on risk scores between the comparators was within acceptable limits. We also observed > 90% agreement on risk categorization (low- or high-risk) across all variables tested. Conclusions The extensive analytical validation data for the CanAssist-Breast test, evaluating immunohistochemistry performance, risk score generation and risk categorization showed excellent agreement across variables, demonstrating that the test is robust