Polyhydroxy-<i>N</i>-alkyl-2-pyrrolidinones as a new class of glycolipid analogues with immune modulation potential

Abstract

<p></p> <p>A focused library of novel <i>N</i>-alkyl-2-pyrrolidinone derivatives <b>3a–e</b> was synthesized from d-galactose employing a multistep chiron approach. These novel glycolipid analogues exhibited lipopolysaccharide-mediated splenocyte proliferation with no apparent toxicity against murine splenocytes. Various immunological assays on dendritic cells, macrophages, and human peripheral blood mononuclear cells have ascertained the immunostimulatory activity of these new glycolipid analogues.</p