Protective effects of chlorella vulgaris in alcohol Intoxication

Abstract Objectives: The aim of the study, to investigate the effect of Chlorella vulgaris on the liver, kidney and heart MAPK (Mitogen-activated protein kinase), lipid peroxidation antioxidant enzyme activity with ethyl alcohol toxification. Materials and Methods: 10-12 monthly, weighing 200-250 gr, 24 adult male Sprague Dawley rats were used. Rats were divided into 3 (n=8) groups which 2 experiments and a control. 5mg/kg of isocaloric maltose was given to the control group by gavage. 15 g/kg ethyl alcohol diluted with 50% water was given to the alcohol group and 300 mg/kg C. vulgaris and then 15 g/kg ethyl alcohol diluted with 50% water were given to C. vulgaris group. At the end of the experiment tissue samples were taken. Blood samples were collected into EDTA tubes and the tissues were kept at -20°C. The blood and tissue samples were used to investigate the GSH/GSH-Px, MAPK activity and MDA levels. Results: MAPK activities in liver and lung tissue were increased with C. vulgaris which decrease with ethyl alcohol while MAPK activities in kidney and heart tissue decreased with C. vulgaris. The reduction in tissue GSH-Px levels with alcohol was increased significantly with C. vulgaris application (

Efeito de altas temperaturas no crescimento e nas respostas fisiológicas ao estresse de juvenis de robalo-flecha (Centropomus undecimalis)

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Agrárias, Programa de Pós-Graduação em Aquicultura, Florianópolis, 2016.Os efeitos de altas temperaturas (28, 31, 34 e 37 °C) sobre o crescimento, sobrevivência e respostas fisiológicas de juvenis de robalo-flecha (Centropomus undecimalis) foram investigados nesse trabalho. Os tratamentos foram feitos em triplicatas e eram constituídos de quatro sistemas de recirculação independentes, cada um composto por três tanques de 150 L. Os animais (peso inicial de 3,4 g) criados durante 30 dias foram alimentados quatro vezes diariamente até a saciedade aparente. Além da biometria inicial realizaram-se mais duas biometrias, aos 15 e 30 dias de experimento. A composição centesimal dos peixes não sofreu influência dos tratamentos. Amostras de tecidos foram coletadas para análises de proliferação celular (fosfohistona H3) e estresse (glicose, cortisol e Hsp 70). De acordo com os resultados não houve relação entre o incremento de temperatura e a proliferação celular em brânquia e coração. Entre os tratamentos, não houve diferença significativa nos resultados dos parâmetros bioquímicos sanguíneos, cortisol e glicose. Já as respostas imuno-histoquímicas ao estresse térmico (Hsp 70) apresentaram diferenças significativas entre a temperatura mais alta e os outros tratamentos. A sobrevivência e os parâmetros zootécnicos foram afetados significativamente pela temperatura. O aumento da temperatura resultou em 71,3% de mortalidade dos animais criados a 37 °C. Os resultados sugerem que a temperatura ideal para a criação de juvenis de robalo-flecha está acima dos 28 °C e não deve ultrapassar os 34 °C. Tendo como base uma análise de regressão do ganho de peso, a temperatura mais adequada foi 31,9 °C.Abstract : The effects of high temperatures (28, 31, 34 and 37 °C) on growth, survive and physiological responses of common snook (Centropomus undecimalis) juveniles were investigated. Treatments were performed in triplicate and consisted of four independent recirculating systems, each comprised of three 150-L tanks. Animals (initial weight 3.4 ± 0.54 g) were reared for 30 days and fed a commercial diet four times a day to apparent satiation. Samples (for growth parameters and tissue collection) were taken at the beginning and after 15 and 30 days of the experiment. The proximate composition of the fish whole body was not influenced by the treatments. Tissue samples were collected for the analyses of cell proliferation (phosphohistone H3) and stress responses (glucose, cortisol and Hsp 70). Results showed no influence of increasing temperature and cell proliferation in gills and heart. Among the treatments, there was no significant difference in the results of blood biochemical parameters, cortisol and glucose. However, the immunohistochemical response to heat stress (Hsp 70) had significant differences between the highest temperature and the other treatments. Survival and growth parameters were significantly affected by temperature. Increasing temperature to 37 °C resulted in 71.3% of mortality. The overall results suggest that the ideal temperature for rearing common snook juveniles is above 28 °C and should not exceed 34 °C. Based on a regression analysis of weight gain, the most suitable temperature was 31.9 °C

Uma análise das protagonistas de A vida invisível de Euridice Gusmão e Purple Hibiscus sob as lentes do dialogismo e da crítica feminista

Studies in comparative literature have brought great contribution to this area of knowledge and grounded countless academic research studies over the years. In this regard, this research adds a new component to comparative studies, viz., the dialogic approach to literary studies, and aims to find out at what extent the heterodiscourse related to women in a patriarchal/male chauvinist society is represented in the novels A vida invisível de Eurídice Gusmão (2016), written by Brazilian author Martha Batalha, and Purple hibiscus (2003), written by Nigerian author Chimamanda Adichie, the corpus of this research. These works, which are analyzed from the perspective of the theory of dialogism of the Bakhtin Circle (Bakhtin, Voloshinov, Medvedev) in dialogue with feminist criticism, reflect and refract the position of women in contemporary societies as the main characters of the novels are placed in positions of inferiority. Methodologically, this bibliographical research follows the Circle’s orientation that the analysis of a text starts from the text and reaches the context of small time and great time. The results of this comparative/dialogical study between the novels prompted reflections not only on the position of the women represented in the novels and lived in the world of life of the novel’s context of production, but also on the dialogue between dialogism and feminist criticism and its contribution to literary analysis.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESOs estudos realizados em literatura comparada ao longo dos anos têm sido de grande contribuição para essa área do conhecimento e respaldado inúmeras pesquisas no âmbito acadêmico. Nessa perspectiva, essa análise acrescenta aos estudos comparatistas a abordagem dialógica dos estudos literários, e busca de que maneira o heterodiscurso em relação à mulher nos moldes de uma sociedade patriarcal/machista é representado nas obras A vida invisível de Eurídice Gusmão (2016) da escritora brasileira Martha Batalha e Purple hibiscus (2003) da autora nigeriana Chimamanda Adichie, corpus desta pesquisa. As obras, que são analisadas com base na teoria do dialogismo do Círculo bakhtiniano (Bakhtin, Volóchinov e Medviédev) em diálogo com a crítica feminista, refletem e refratam a posição da mulher na contemporaneidade, um tema bastante consistente e significativo nas sociedades dos dias atuais, tendo em vista que as narradoras dos romances são personagens centrais que estão postas em posições de inferioridade. Metodologicamente, esta pesquisa bibliográfica segue as orientações do Círculo de que a análise parte do texto, indo ao contexto do pequeno tempo e do grande tempo. Os resultados desse estudo comparativista/dialógico entre os romances trouxeram reflexões não apenas sobre o posicionamento das mulheres representadas nos romances e vivida no mundo da vida de seus contextos de produção, mas também sobre o diálogo entre o dialogismo e a crítica feminista e a sua contribuição para a análise literária

Atrelando a matemática com a literatura infantil

O referido trabalho “Atrelando a matemática com a literatura infantil”, tem como intuito explanar sobre algumas vivências desenvolvidas no Centro Municipal de Educação Infantil Professora Antônia Fernanda Jalles, com a turma do nível III, crianças de aproximadamente entre 3 a 4 anos. Turma está que atuei como bolsista do Programa Institucional de Bolsa de Iniciação à Docência (PIBID-UFRN) no subprojeto de Pedagogia. O presente trabalho objetivou suscitar ainda mais o gosto das crianças pela literatura, aguçando essas ações através de jogos matemáticos que intercalam todo o imaginário proposto pela literatura infantil. Sabemos sobre a importância da leitura desde a mais tenra idade e de toda arte que esta proporciona como também, entende-se por necessário que as crianças tenham essa interdisciplinaridade entre os campos de conhecimentos. Tal proposta vem de encontro ao que explana Cláudia Inês (2012) no que se refere ao lúdico na aprendizagem e de jogos como subsídios para as atividades intelectuais indispensáveis para a aprendizagem das crianças. Ancorando-se em: BRENELLI (1996), RCNEI (1998), ZABALA (1998), entre outros, este trabalho foi estruturado. Alguns resultados obtidos é a percepção do crescimento da criança de forma integral no desenvolvimento do projeto, pois as mesmas já conseguem compreender a importância da leitura, bem como do. Desta forma, reconhecimento numérico e noções matemáticas basilares essa prática de ensino só propiciou cada vez mais um enxergar diferenciado sobre a docência e sua conjectura, possibilitando uma vivência e um compartilhamento sobre essa prática de ensino

Niche partitioning and coexistence of two spiders of the genus peucetia (araneae, oxyopidae) inhabiting trichogoniopsis adenantha plants (asterales, asteraceae)

Niche theory suggests that the coexistence of ecologically similar species in the same site requires some form of resource partitioning that reduces or avoids interspecific competition. Here, from July 2013 to December 2015, we investigated spatial niche differentiation at three different scales of two sympatric congeneric spiders, Peucetia rubrolineata and P. flava, along an altitudinal gradient in shaded and open areas in an Atlantic forest in Serra do Japi, SP, Brazil. These spiders are peculiar in that they present an exclusive association with the plant Trichogoniopsis adenantha (Asteraceae). In theory, the coexistence of two Peucetia species could be explained by: (1) microhabitat segregation with individuals from different species occupying different parts of the same plants; (2) mesohabitat segregation with different species using plant in different environments; (3) macrohabitat segregation, where different species would not co-occur along the altitudinal gradient. With respect to micro-habitat use, in both species, different instars used different plant parts, while the same instars of both species used the same type of substrate. However, the two Peucetia species segregated by meso-habitat type, with P. rubrolineata preferring T. adenantha plants in shaded areas and P. flava preferring those in open areas. Our results support the hypothesis of niche partitioning begetting diversity, and highlight the importance of analyzing habitat use at multiple scales to understand mechanisms related to coexistence1410CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPnão temnão temnão te

The beating heart: artificial intelligence for cardiovascular application in the clinic

Artificial intelligence (AI) integration in cardiac magnetic resonance imaging presents new and exciting avenues for advancing patient care, automating post-processing tasks, and enhancing diagnostic precision and outcomes. The use of AI significantly streamlines the examination workflow through the reduction of acquisition and postprocessing durations, coupled with the automation of scan planning and acquisition parameters selection. This has led to a notable improvement in examination workflow efficiency, a reduction in operator variability, and an enhancement in overall image quality. Importantly, AI unlocks new possibilities to achieve spatial resolutions that were previously unattainable in patients. Furthermore, the potential for low-dose and contrast-agent-free imaging represents a stride toward safer and more patient-friendly diagnostic procedures. Beyond these benefits, AI facilitates precise risk stratification and prognosis evaluation by adeptly analysing extensive datasets. This comprehensive review article explores recent applications of AI in the realm of cardiac magnetic resonance imaging, offering insights into its transformative potential in the field

Protective effects of L-carnitine and co-enzyme Q10 against axidative stress damage in hypertension

Abstract : In this study, it was aimed to investigate the effects of L-carnitine and Co-enzyme Q10 administration together with ACE Inhibitor (ACE inh.) on oxidative stress parameters in liver, brain and kidney tissues in L-NAME hypertensive rats. At the study, divided all rats into eight groups, four groups with 14 days of experiment time and four groups with 28 days of experiment time. At the end of the experiment, the rats were euthanized and their liver, brain and kidney tissues were taken. Malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) activities were measured in tissue supernatants. While NO and MDA levels increased in all tissues, a significant decrease was observed in GSH levels (P<0.001). In conclusion, it is suggested that supplementation of L-carnitine and CoQ10 can be considered as a combination therapy strategy for patients prone to higher levels of oxidative stress and inflammation