A Reinforcement Learning Badminton Environment for Simulating Player Tactics (Student Abstract)

Recent techniques for analyzing sports precisely has stimulated various approaches to improve player performance and fan engagement. However, existing approaches are only able to evaluate offline performance since testing in real-time matches requires exhaustive costs and cannot be replicated. To test in a safe and reproducible simulator, we focus on turn-based sports and introduce a badminton environment by simulating rallies with different angles of view and designing the states, actions, and training procedures. This benefits not only coaches and players by simulating past matches for tactic investigation, but also researchers from rapidly evaluating their novel algorithms.Comment: Accepted by AAAI 2023 Student Abstract, code is available at https://github.com/wywyWang/CoachAI-Projects/tree/main/Strategic%20Environmen

Extraordinarily wide-view circular polarizers for liquid crystal displays

A new broadband wide-view circular polarizer is proposed for high transmittance multi-domain vertical-alignment liquid crystal displays (MVA LCDs). This configuration only requires one biaxial plate in the conventional circular polarizer. The optimal film parameters are obtained analytically through spherical trigonometric method on the Poincare sphere and through computer-aided parameter search method. According to this design, the high transmittance MVA LCD exhibits a contrast ratio CR \u3e 200: 1 over similar to 80 degrees viewing cone

Nuclear Export Signal Mutation of Epidermal Growth Factor Receptor Enhances Malignant Phenotypes of Cancer Cells

Nuclear epidermal growth factor receptor (EGFR) has been shown to be correlated with drug resistance and a poor prognosis in patients with cancer. Previously, we have identified a tripartite nuclear localization signal (NLS) within EGFR. To comprehensively determine the functions and underlying mechanism of nuclear EGFR and its clinical implications, we aimed to explore the nuclear export signal (NES) sequence of EGFR that is responsible for interacting with the exportins. We combined in silico prediction with site-directed mutagenesis approaches and identified a putative NES motif of EGFR, which is located in amino acid residues 736-749. Mutation at leucine 747 (L747) in the EGFR NES led to increased nuclear accumulation of the protein via a less efficient release of the exportin CRM1. Interestingly, L747 with serine (L747S) and with proline (L747P) mutations were found in both tyrosine kinase inhibitor (TKI)-treated and -naïve patients with lung cancer who had acquired or de novo TKI resistance and a poor outcome. Reconstituted expression of the single NES mutant EGF

The Adjuvant Therapy of Intravenous Laser Irradiation of Blood (ILIB) on Pain and Sleep Disturbance of Musculoskeletal Disorders

(1) Background: Musculoskeletal pain is both intractable and irritating. Intravenous Laser Irradiation of Blood (ILIB) therapy has been used as pain control treatment for this condition. However, there remains a lack of clear evidence regarding ILIB on pain control. This study aimed to reveal the result of changes in patient pain intensity after receiving ILIB therapy. (2) Methods: We conducted a retrospective analysis of pain scores and sleep quality from 76 patients diagnosed with musculoskeletal disease who received three courses of ILIB therapy. Each course included ten sessions of ILIB treatment over ten consecutive days. During ILIB therapy, patients were inserted with a laser fiber optic needle which irradiated blood cells via a 632.8 nm Helium-Neon laser light over a period of 60 min. Pain scores were evaluated using the Visual Analogue Scale (VAS), whereas sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). These scores would be recorded both before and after each ILIB treatment course. (3) Results: The mean of all patients’ initial VAS score was 5.35. After completing three courses of ILIB treatment, the mean VAS score decreased to 2.2, which indicated a significant reduction in pain intensity. Additionally, patients experienced sleep quality improvement levels from PSQI 8.97 to 5.53 upon completion of three courses of ILIB treatment. (4) Conclusions: Intravenous Laser Irradiation of Blood (ILIB) resulted in a positive pain control effect on patients with musculoskeletal disease, especially for those with moderate to severe pain intensity (initial VAS score >4). Additionally, patients experienced better sleep quality as a result of their pain relief after receiving ILIB treatment