Imperilled waterscapes

This paper examines the historical waterscapes of Bengaluru, now imperilled by development. Earlier a garden city, the agrarian landscape of Bengaluru was formerly supplied with water from an interconnected lake system. This system has since been fragmented due to urbanization and changes in land cover, impacting local institutions and livelihoods dependent on the lakes. In this paper, we use the case of the city’s largest lake, Bellandur, to demonstrate the transformation of the waterscape from an open semi-arid landscape pre-dating the city into an agrarian water-dependent landscape characterized by flows of water in pre-colonial and colonial Bengaluru, and finally into a concretized landscape and the individualization of lakes in the “modern” city. Claims to and associations with the lake ecosystem have altered through changing hydrological, institutional, and social relations, leading to shifts in imaginations of the lake as well

ChemInform Abstract: Synthesis of Boc‐Amino Tetrazoles Derived from α‐Amino Acids

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option

Isolation of Machine Foundations by Barriers

Experimental investigation has been carried out to study the effects due to isolation of foundations subjected to vertical vibration on the displacement amplitude. Tests were conducted on an embedded footing of contact area 45 x 45cm. with different embedments and some on the surface of natural ground. Three isolation barriers viz. air gap, saw dust and sand of various depths were used. From the results of the investigation it was found that an open trench (air gap) around the foundation reduces the displacement amplitude around the footing considerably to an extent of about 75%. Saw dust as a barrier, although not as good as air gap, performs better when compared to sand. The coefficient of attenuation is not a constant for a soil medium but varies with static and dynamic loads. The resonant frequency decreases and resonant amplitude increases by providing isolating barriers

Improving detection of mental health problems in community settings in Nepal: development and pilot testing of the community informant detection tool

Background Despite increasing efforts to expand availability of mental health services throughout the world, there continues to be limited utilization of these services by persons with mental illness and their families. Community-based detection that facilitates identification and referral of people with mental health problems has been advocated as an effective strategy to increase help-seeking and service utilization. The Community Informant Detection Tool (CIDT) was developed for the community informants to identify people with depression, psychosis, alcohol use problems, epilepsy, and child behavioral problems in community settings. The CIDT has been validated in Nepal and found to be effective in promoting treatment initiation. To facilitate replication in other settings, this paper describes the development process of CIDT and the steps to achieve comprehensibility, utility and feasibility. Methods The CIDT was developed in four steps. First, case vignettes and illustrations were created incorporating local idioms of distress for symptoms of each disorder with an expert panel of 25 Nepali mental health professionals. Second, the utility of a draft tool was assessed through focus group discussions (n = 19) and in-depth interviews (n = 6). Third, a practice run was conducted assessing applicability of the tool through IDI among purposively selected community informants (n = 8). Finally, surveys were administered to 105 community informants to assess feasibility. Results The first through third steps led to modifications in the format and presentation of the CIDT. The pilot test found CIDT to be comprehensible and feasible for detection and referral of all conditions except child behavioral problems. Female community health volunteers were recommended as the most appropriate persons to utilize the CIDT. Conclusion Community-based detection using the CIDT for persons in need of mental health care is perceived to be useful and feasible by key community stakeholders who would integrate the tool into their daily activities

A clinical study of trends of ectopic pregnancy and its management in a tertiary care hospital

Background: Ectopic gestation is a gynaecological emergency which culminates in pregnancy loss and causes significant maternal morbidity, mortality besides jeopardizing future conception. The study discusses the incidence, risk factors, symptomatology and management of ectopic pregnancy in a tertiary care teaching hospital.Methods: This was a prospective study of 45 cases of ectopic pregnancies at a tertiary care teaching hospital from January 2012 to December 2013. Information was collected in a structured proforma, tabulated and descriptive analysis was carried out.Results: The incidence of ectopic pregnancy was 1.17%. Majority of the patients (80%) belonged to 20-30 yrs age group. Second gravidas predominated (42.2%). Fallopian tube was the most common site (95.5%). Rudimentary horn ectopic accounted for 4.65%. Previous abdominopelvic surgery (31.1%), IUCD usage (22.2%), PID (20%), abortions (20%), tubectomy (15.5%) were the principal risk factors. 42% of the patients had no risk factor. The triad of amenorrhea, bleeding per vaginum and abdominal pain was seen in 51.1% of cases. Ultrasound, UPT, β-hCG estimation were the diagnostic tools. Ruptured ectopic pregnancy accounted for 64.4%. Nearly 95.5% of patients underwent surgery; salpingectomy (76%). Methotrexate was successful in 4.44%. There was no maternal mortality.Conclusions: Mostly diagnosis, prompt surgical or medical management is cornerstone of treatment. Primary prevention such as improved access to family planning services, sex education, treatment of STI, PID, surgical asepsis  and haemostasis, implementing legislation for dispensing MTP drugs ameliorate risk factors and hence reduce ectopic pregnancy

Resonance Line Polarization in Spherically Symmetric Moving Media: a Parametric Study

In the present paper we consider the problem of resonance line polarization formed in the spherically symmetric expanding atmospheres. For the solution of the concerned polarized transfer equation we use the comoving frame formulation, and apply the Accelerated Lambda Iteration (ALI) method. We restrict ourselves to the non-relativistic regime of velocities wherein mainly Doppler shift effects are significant. For our studies, we consider the scattering on a two-level atom, including the effects of partial frequency redistribution (PFR). We present the dependence of linearly polarized profiles on different atmospheric and atomic parameters.Comment: 10 pages, 6 figures, Proceedings of the 9th Solar Polarization Workshop SPW9, A workshop held in Gottingen, Germany, from August 26 to August 30, 201

Anti-Depressant Activity of Zizyphus xylopyrus

The present study was undertaken to investigate the effect of ethanolic extract (ext.), ethyl acetate (EA) fractions and precipitate fraction (ppt.) of total ethanolic extract of Zizyphus xylopyrus on depression in rats. In the present study, the antidepressant effect of Zizyphus xylopyrus was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in rats.Ethanolic extract when administered at an acute dose of 50 mg/kg of body weight (P<0.01) reduced the immobility time by 10 and 15 seconds as compared to the immobility time of control in both the screening models. Similarly EA reduced latter by 30 and 35 secs. The ppt. fraction showed the best activity, reducing the immobility time by 50 and 60 secs. in both the tests. These results showed that after standard i.e. Imipramine HCl (30 mg/kg), the ppt. fraction is potent amongst all the studied drugsThe present study clearly demonstrated that Zizyphus xylopyrus exerts an antidepressant effect in these two behavioral models. It may be due to present of flavonoids.Keywords: Zizyphus xylopyrus, Flavanoides, forced swimming test, tail suspension test

Anti-Depressant Activity of Zizyphus xylopyrus

The present study was undertaken to investigate the effect of ethanolic extract (ext.), ethyl acetate (EA) fractions and precipitate fraction (ppt.) of total ethanolic extract of Zizyphus xylopyrus on depression in rats. In the present study, the antidepressant effect of Zizyphus xylopyrus was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in rats.Ethanolic extract when administered at an acute dose of 50 mg/kg of body weight (P<0.01) reduced the immobility time by 10 and 15 seconds as compared to the immobility time of control in both the screening models. Similarly EA reduced latter by 30 and 35 secs. The ppt. fraction showed the best activity, reducing the immobility time by 50 and 60 secs. in both the tests. These results showed that after standard i.e. Imipramine HCl (30 mg/kg), the ppt. fraction is potent amongst all the studied drugsThe present study clearly demonstrated that Zizyphus xylopyrus exerts an antidepressant effect in these two behavioral models. It may be due to present of flavonoids.Keywords: Zizyphus xylopyrus, Flavanoides, forced swimming test, tail suspension test

SACRED LANDSCAPES AS REPOSITORIES OF BIODIVERSITY. A CASE STUDY FROM THE HARIYALI DEVI SACRED LANDSCAPE, UTTARAKHAND

The present study was carried out in the Hariyali Devi sacred landscape of Garhwal Himalaya in Uttarakhand State of India. The study area falls under the jurisdiction of the Forest Department, having the status of reserve forest. The land scape is dedicated to the deity “Hariyali Devi” and that plays a major role in conserving the biodiversity of this land scape. Taboos, rituals and socio-cultural practices are associated with conservation practices. The study recorded 98 plant species, representing 88 genera and 46 families with different economic values. The dominant family was Rosaceae, which recorded the highest (10) number of species. Out of 98 plant species the dominant life form contribution was of herbs (52), shrubs (26) and tree species (21). Almost 82 plants species in the landscape are of medicinal importance, 15 species are used for timber and construction purposes, 19 species with different edible plant parts, such as fruits, flowers, seeds and rhizomes. The information about the uses/economic value of different plant species was gathered directly by interviewing knowledgeable elderly local villagers (including women)

Identification of Potential Drug Targets Implicated in Parkinson's Disease from Human Genome: Insights of Using Fused Domains in Hypothetical Proteins as Probes

High-throughput genome sequencing has led to data explosion in sequence databanks, with an imbalance of sequence-structure-function relationships, resulting in a substantial fraction of proteins known as hypothetical proteins. Functions of such proteins can be assigned based on the analysis and characterization of the domains that they are made up of. Domains are basic evolutionary units of proteins and most proteins contain multiple domains. A subset of multidomain proteins is fused domains (overlapping domains), wherein sequence overlaps between two or more domains occur. These fused domains are a result of gene fusion events and their implication in diseases is well established. Hence, an attempt has been made in this paper to identify the fused domain containing hypothetical proteins from human genome homologous to parkinsonian targets present in KEGG database. The results of this research identified 18 hypothetical proteins, with domains fused with ubiquitin domains and having homology with targets present in parkinsonian pathway