A Comprehensive Study of Repetitive Transcranial Magnetic Stimulation in Parkinson's Disease

The clinical benefits of repetitive transcranial magnetic stimulation (rTMS) for Parkinson's disease (PD) remain controversial. We performed a comprehensive study to examine whether rTMS is a safe and effective treatment for PD. Twelve PD patients received rTMS once a week. The crossover study design consisted of 4-week sham rTMS followed by 4-week real rTMS. The Unified Parkinson's Disease Rating Scale (UPDRS), Modified Hoehn and Yahr Stage, Schwab and England ADL Scale, Actigraph, Mini-Mental State Examination, Hamilton Depression Scale, Wechsler Adult Intelligence Scale-revised, and cerebral blood flow (CBF) and cerebrospinal fluid (CSF) examinations were used to evaluate the rTMS effects. Under both drug-on and drug-off conditions, the real rTMS improved the UPDRS scores significantly, while the sham rTMS did not. There were no significant changes in the results of the neuropsychological tests, CBF and CSF. rTMS seems to be a safe and effective therapeutic option for PD patients, especially in a wearing-off state

Mild form of Danon disease: two case reports

International audienc

El Mercado Único. La Europa sin Fronteras Interiores: educación y formación para la CE. Universidad Politécnica de Madrid

Duración del vídeo: 1h 38min 05sCiclo de conferencias sobre el Mercado Único dentro de la Acción Institucional'93 celebrado en la Universidad Politécnica de Madrid y presidido por el Secretario de Estado para las CC.EE, D. Carlos Westendorp junto con el Rector de la Universidad Politécnica de Madrid D. Rafael Portaencasa

Additional file 1: Figure S1. of Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders

Standard curves for measurement of sAPPα and sAPPβ concentrations. Typical standard curves for sAPPα and sAPPβ obtained using the original method (A) and those obtained using our modified method (B) are shown. The modified method yielded apparent differences, including higher values of absorbance at 450 nm at lower concentrations and the requirement for a much shorter time for the TMB reaction than the original method. (TIFF 325 kb