79 research outputs found
The Effect of Particle Size and Concentration on Low-Frequency Terahertz Scattering in Granular Compacts
Fundamental knowledge of scattering in granular compacts is essential to
ensure accuracy of spectroscopic measurements and determine material
characteristics such as size and shape of scattering objects. Terahertz
time-domain spectroscopy (THz-TDS) was employed to investigate the effect of
particle size and concentration on scattering in specially fabricated compacts
consisting of borosilicate microspheres in a polytetrafluoroethylene (PTFE)
matrix. As expected, increasing particle size leads to an increase in overall
scattering contribution. At low concentrations, the scattering contribution
increases linearly with concentration. Scattering increases linearly at low
concentrations, saturates at higher concentrations with a maximum level
depending on particle size, and that the onset of saturation is independent of
particle size. The effective refractive index becomes sublinear at high
particle concentrations and exceeds the linear model at maximum density, which
can cause errors in calculations based on it, such as porosity. The observed
phenomena are attributed to the change in the fraction of photons propagating
ballistically versus being scattered. At low concentrations, photons travel
predominately ballistically through the PTFE matrix. At high concentrations,
the photons again propagate ballistically through adjacent glass microspheres.
In the intermediate regime, photons are predominately scattered
Analysis of THz scattering of compacted granular materials using THz-TDS
Scattering of terahertz radiation in compacts is of great interest due to its potential to non-destructively assess various structural elements such as particle size and defects in compacts. In this study, we isolate the scattering contributions to the loss coefficient of borosilicate glass microspheres suspended in a polytetrafluoroethylene (PTFE) compact measured by terahertz time-domain spectroscopy. The particle size and concentration of microspheres in the compacts were varied to resolve their effect on terahertz scattering
Polymer pellet fabrication for accurate THz-TDS measurements
We investigate fabrication of compacts using polytetrafluoroethylene (PTFE) and polyethylene (PE), and the effect of compaction conditions on their terahertz transmission properties. The conditions used to fabricate compressed powder samples for terahertz time-domain spectroscopy (THz-TDS) can impact the accuracy of the measurements and hence the interpretation of results. This study investigated the effect of compaction conditions on the accuracy of the THz-TDS analysis. Two polymers that are commonly used as matrix materials in terahertz spectroscopy studies were explored using a compaction simulator and a hydraulic press for sample preparation. THz-TDS was used to determine the refractive index and loss coefficient to compare the powder compacts (pellets) to the values of solid material. Sample porosity, axial relaxation and tensile strength were measured to assess the material’s suitability for terahertz spectroscopy. It was found that PTFE is the preferable material for creating THz-TDS samples due to its low porosity and high tensile strength. PE was found to show significant porosity at all compaction pressures making it an unsuitable material for the accurate determination of optical parameters from THz-TDS spectroscopy measurements. The larger particle sizes of PE resulted in compacts that exhibited significantly lower tensile strength than those made from PTFE making handling and storage difficult
Observation of spurious spectral features in mixed-powder compressed pellets measured by terahertz time-domain spectroscopy
Spurious loss features were observed in mixed-powder compressed pellets measured in transmission using terahertz time-domain spectroscopy. Loss features were identified in two types of pellets: PTFE-glass microspheres and PTFE-lactose. The features were found to be dependent on grain size and concentration. An explanation is proposed, based on varying optical thickness of the sample material
Effect of particle size and concentration on low-frequency terahertz scattering in granular compacts
Fundamental knowledge of scattering in granular compacts is essential to ensure accuracy of spectroscopic measurements and determine material characteristics such as size and shape of scattering objects. Terahertz time-domain spectroscopy (THz-TDS) was employed to investigate the effect of particle size and concentration on scattering in specially fabricated compacts consisting of borosilicate microspheres in a polytetrafluoroethylene (PTFE) matrix. As expected, increasing particle size leads to an increase in overall scattering contribution. Scattering increases linearly at low concentrations, saturates at higher concentrations with a maximum level depending on particle size, and that the onset of saturation is independent of particle size. The effective refractive index becomes sublinear at high particle concentrations and exceeds the linear model at maximum density, which can cause errors in calculations based on it, such as porosity. The observed phenomena are attributed to the change in the fraction of photons propagating ballistically versus being scattered. At low concentrations, photons travel predominately ballistically through the PTFE matrix. At high concentrations, the photons again propagate ballistically through adjacent glass microspheres. In the intermediate regime, photons are predominately scattered
Analysis of Granular Packing Structure by Scattering of THz Radiation
Scattering methods are widespread used to characterize the structure and
constituents of matter on small length scales. This motivates this introductory
text on identifying prospective approaches to scattering-based methods for
granular media. A survey to light scattering by particles and particle
ensembles is given. It is elaborated why the established scattering methods
using X-rays and visible light cannot in general be transferred to granular
media. Spectroscopic measurements using Terahertz radiation are highlighted as
they to probe the scattering properties of granular media, which are sensitive
to the packing structure. Experimental details to optimize spectrometer for
measurements on granular media are discussed. We perform transmission
measurements on static and agitated granular media using Fourier-transform
spectroscopy at the THz beamline of the BessyII storage ring. The measurements
demonstrate the potential to evaluate degrees of order in the media and to
track transient structural states in agitated bulk granular media.Comment: 12 Pages, 9 Figures, 56 Reference
Sub-THz radiation from dielectric capillaries with reflectors
In this report we present experimental investigations of THz radiation
generated from a corrugated and a non-corrugated capillary with reflectors,
using a femtosecond electron beam of LUCX accelerator at KEK, Japan. We discuss
measurements of radiation angular distributions and their comparison with
Particle In Cell simulations, and also investigate an off-central propagation
of the beam in the capillaries based on experimental measurements and
simulations.Comment: 5 pages, 5 figure
以書付奉伺候(十五軒程当時相休居候、旅籠取立云々)
Superposition of orbital eigenstates is crucial to quantum technology utilizing atoms, such as
atomic clocks and quantum computers, and control over the interaction between atoms and
their neighbours is an essential ingredient for both gating and readout. The simplest coherent
wavefunction control uses a two-eigenstate admixture, but more control over the spatial
distribution of the wavefunction can be obtained by increasing the number of states in the
wavepacket. Here we demonstrate THz laser pulse control of Si:P orbitals using multiple
orbital state admixtures, observing beat patterns produced by Zeeman splitting. The beats are
an observable signature of the ability to control the path of the electron, which implies we
can now control the strength and duration of the interaction of the atom with different
neighbours. This could simplify surface code networks which require spatially controlled
interaction between atoms, and we propose an architecture that might take advantage of this
Fano resonance engineering in mirror-symmetry-broken THz metamaterials
We introduce a comprehensive approach to the design of mirror-symmetry broken terahertz (THz) metamaterials and present both the simulation and experimental results which show the desired asymmetric Fano resonances and electromagnetic induced transparency (EIT)-like windows. With a full wave simulation, we find these asymmetry-induced resonance modes possess extremely high quality factors and they broaden with increase of the structure asymmetry. This phenomenon arises from the destructive interference of a super-radiative bright mode and a sub-radiative dark mode which can’t be excited directly. Surface current and electric field distributions are analyzed to explain the emergence of these Fano resonances. An intuitive mechanical coupled oscillator model is derived to explain the unique line-shape of such Fano resonances. Moreover, large resonant frequency tuning (50 GHz) of Fano resonance has been demonstrated by temperature induced phase change in liquid crystals. We believe that the Fano resonance in THz metamaterials may serve as a strong building block for passive or active THz elements with potential applications for future detection and sensing systems and devices.The authors would like to thank the UK Engineering and Physical Sciences Research Council (EPSRC) for the support through the Platform Grant for Liquid Crystal Photonics (EP/F00897X/1). Xuefeng Li would like to acknowledge the support from Cambridge Trust.This is the author accepted manuscript. It is currently under an indefinite embargo pending publication by Springer
Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.
Liver fibrosis is a major cause of morbidity and mortality. It is characterised by excessive extracellular matrix (ECM) deposition from activated hepatic stellate cells (HSCs). Although potentially reversible, treatment remains limited. Understanding how ECM influences the pathogenesis of the disease may provide insight into novel therapeutic targets for the disease. The extracellular protein Epimorphin (EPIM) has been implicated in tissue repair mechanisms in several tissues, partially, through its ability to manipulate proteases. In this study, we have identified that EPIM modulates the ECM environment produced by activated hepatic stellate cells (HSCs), in part, through down-regulation of pro-fibrotic Sex-determining region Y-box 9 (SOX9).Influence of EPIM on ECM was investigated in cultured primary rat HSCs. Activated HSCs were treated with recombinant EPIM or SOX9 siRNA. Core fibrotic factors were evaluated by immunoblotting, qPCR and chromatin immunoprecipitation (ChIP).During HSC activation EPIM became significantly decreased in contrast to pro-fibrotic markers SOX9, Collagen type 1 (COL1), and α-Smooth muscle actin (α-SMA). Treatment of activated HSCs with recombinant EPIM caused a reduction in α-SMA, SOX9, COL1 and Osteopontin (OPN), while increasing expression of the collagenase matrix metalloproteinase 13 (MMP13). Sox9 abrogation in activated HSCs increased EPIM and MMP13 expression.These data provide evidence for EPIM and SOX9 functioning by mutual negative feedback to regulate attributes of the quiescent or activated state of HSCs. Further understanding of EPIM's role may lead to opportunities to modulate SOX9 as a therapeutic avenue for liver fibrosis
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