New Inflation in Waterfall Region

We introduce a class of new inflation models within the waterfall region of a generalized hybrid inflation framework. The initial conditions are generated in the valley of hybrid preinflation. Both single-field and multi-field inflationary scenarios have been identified within this context. A supersymmetric realization of this scenario can successfully be achieved within the tribrid inflation framework. To assess the model's viability, we calculate the predictions of inflationary observables using the $\delta N$ formalism, demonstrating excellent agreement with the most recent Planck data. Furthermore, this model facilitates successful reheating and nonthermal leptogenesis, with the matter-field component of the inflaton identified as a sneutrino.Comment: 15 pages, 9 figure

Spectrophotometric Quantification of Trace Elements and Toxic Metals in Raw Milk Samples of Peshawar City, Pakistan

The present study focused on the physicochemical characterization and spectrophotometric determination of the concentrations of trace elements (Zn, Cu, Fe and Mn) and toxic heavy metals (Cd and Pb) in raw milk samples collected from various commercial sites of Peshawar city, Pakistan. Evaluation of the nutritional values as well as the possible health concerns associated with the consumption of contaminated milk shown the average percentage composition of protein, fats, solid non-fats, lactose, salts and added water in the milk sample as 2.78, 4.81, 6.41, 3.05, 0.47 and 31.1 %, respectively. The values of pH, conductivity, density and freezing point were observed as 6.59, 3.51 mS/cm, 1.04 g/mL and -0.3674 ºC at 26 ºC. The physicochemical characteristics such as percentage protein, fat, lactose, salts, water, solid not fat, total solids, pH, conductivity and density were evaluated and found in the safe limits of the WHO/FAO. The average concentration of trace elements such as zinc and copper were found to be 1.4035 mg/L and 0.2588 mg/L, respectively. The concentration of Zn and Cu was found within permissible limits suggested by WHO. However, the average concentration of Fe, Mn, Cd and Pb were found higher than the permissible limits of WHO. The observed concentrations were: Fe = 1.5553, Mn = 0.4354, Cd = 0.1865 and Pb = 1.1162 mg/L. The presence of the non-essential and hazardous Cd and Pb in milk samples even in lower concentrations may cause severe health problems since these are the most noxious pollutants due to their non-biodegradable and bio-accumulative nature. Over-dose of Fe and Mn also leads to several health issues. A thorough and more precise investigation of raw milk consumption in Peshawar is highly recommended to ascertain the actual reasons and sources in the larger public interests

The Impact of Children on Parental Purchasing Behavior

Children have a major influence on their parents' purchases of similar products. Children are a dominant market for marketers to consider when making strategy choices since they are part of a family unit. This market is active in three ways: first, it is a large market in and of itself; second, it is a key influencer in facilitating purchasing decisions; and third, it is a possible future market. The focus of this research is on children's second position. They become the focal point of family expectations, and parents are more receptive to their recommendations when making purchases. This research study explains the effect of children on parental purchase behavior in the twin cities of Islamabad and Rawalpindi using a survey as a data collection method. Parents are among the participants in this research. The relationship between parental purchase behavior (PPB) and age of child (AOC), importance of child (IOC), product category (PC), communication pattern (CP), and family orientation is revealed by multiple regression analysis (FO). The age of the child (AOC), family orientation (FO), and Product Category (PC) are the three most significant factors that affect parental buying behavior. The paper concludes that children have a major influence on their parents' decisions

Effect of Moringa Oleifera Leaves Meal or Its Combination with Phytase Enzyme on Nutrient Digestibility of Broiler

Moringa oleifera leaves meal are good source of amino acids, Vitamins, and it has medicinal uses also are rich in carotene level and ascorbic acid with a good amino acid profile its leaves given with combination of Phytase enzyme because Poultry required enzymes which help in feed breakdown because chicken have not enzyme for fibres break down. The using of enzyme have many benefits in poultry diets include not only enhanced feed conversion, performance and nutrient digestibility. The present study was undertaken in order to determine the effect of Moringa oleifera leaves meal or its combination with phytase enzyme on nutrient digestibility of broiler. Two hundred day-old Ross broiler chicks from a commercial hatchery were purchased & after initial weight; birds were arbitrarily separated in groups, i.e. A (control) was offered 0% Moringa oleifera meal whereas; 1.25% (group B), 2.5% (group C) and 3.75% (group D) moringa oleifera leaves meal and with combination of 0 g/kg group A (control), 0.025 g/kg (group B), 0.075 g/kg (group C) and 0.05 g/kg (group D) phytase enzyme provided in broiler feed. Parameters which selected in present research work as, weight gains, feed intake, water intake, feed conversion ratio nutrient digestibility calculated. The results shows that feed intake was significantly higher in group A followed by group B, group C, and group D (g/chick), the higher water intake was recorded in group A, followed by other treated groups B, C and D. Live body weight gain was significantly higher in group C followed by group A, group B, and group D (chick). Feed conversion ratio was significantly (p˂0.05) better in group C, followed by group A, B and group D. Furthermore, crude protein digestibility starter/finisher was recorded significantly higher in group C followed by control group A, group B and group D. Metabolizable energy starter/finisher was Maximum in group C followed by control (A), group B and group D. Keywords- Broiler birds, Moringa oleifera, phytase enzyme, body weight gain, nutrient digestibility. DOI: 10.7176/JBAH/11-10-04 Publication date:May 31st 202

Long-insert sequence capture detects high copy numbers in a defence-related beta-glucosidase gene βglu-1 with large variations in white spruce but not Norway spruce

Conifers are long-lived and slow-evolving, thus requiring effective defences against their fast-evolving insect natural enemies. The copy number variation (CNV) of two key acetophenone biosynthesis genes Ugt5/Ugt5b and βglu-1 may provide a plausible mechanism underlying the constitutively variable defence in white spruce (Picea glauca) against its primary defoliator, spruce budworm. This study develops a long-insert sequence capture probe set (Picea_hung_p1.0) for quantifying copy number of βglu-1-like, Ugt5-like genes and single-copy genes on 38 Norway spruce (Picea abies) and 40 P. glauca individuals from eight and nine provenances across Europe and North America respectively. We developed local assemblies (Piabi_c1.0 and Pigla_c.1.0), full-length transcriptomes (PIAB_v1 and PIGL_v1), and gene models to characterise the diversity of βglu-1 and Ugt5 genes. We observed very large copy numbers of βglu-1, with up to 381 copies in a single P. glauca individual. We observed among-provenance CNV of βglu-1 in P. glauca but not P. abies. Ugt5b was predominantly single-copy in both species. This study generates critical hypotheses for testing the emergence and mechanism of extreme CNV, the dosage effect on phenotype, and the varying copy number of genes with the same pathway. We demonstrate new approaches to overcome experimental challenges in genomic research in conifer defences

Decoupling of height growth and drought or pest resistance tradeoffs is revealed through multiple common-garden experiments of lodgepole pine

14 páginas.- 4 figuras.- 1 tabla.- 101 referencias.- Supplementary material is available online at Evolution (https://academic.oup.com/evolut/qpad004) . A correction has been published: Evolution, Volume 77, Issue 4, 1 April 2023, Page 1174, https://doi.org/10.1093/evolut/qpad030 Issue Section: Correction This is a correction to: Yang Liu, Nadir Erbilgin, Eduardo Pablo Cappa, Charles Chen, Blaise Ratcliffe, Xiaojing Wei, Jennifer G Klutsch, Aziz Ullah, Jaime Sebastian Azcona, Barb R Thomas, Yousry A El-Kassaby, Decoupling of height growth and drought or pest resistance tradeoffs is revealed through multiple common-garden experiments of lodgepole pine, Evolution, 2023; qpad004, https://doi.org/10.1093/evolut/qpad004 In the originally published version of this manuscript, the images for Figures 3 and 4 were erroneously transposed. The images are now in their correct position to align with their respective legends. The Funding section was erroneously removed, and its details situated at the end of the Acknowledgements section. Funding details are now situated within the replaced Funding section. The publisher would like to apologise for the errors introduced here. The errors have been corrected in the article online.The environment could alter growth and resistance tradeoffs in plants by affecting the ratio of resource allocation to various competing traits. Yet, how and why functional tradeoffs change over time and space is poorly understood particularly in long-lived conifer species. By establishing four common-garden test sites for five lodgepole pine populations in western Canada, combined with genomic sequencing, we revealed the decoupling pattern and genetic underpinnings of tradeoffs between height growth, drought resistance based on δ13C and dendrochronology, and metrics of pest resistance based on pest suitability ratings. Height and δ13C correlation displayed a gradient change in magnitude and/or direction along warm-to-cold test sites. All cold test sites across populations showed a positive height and δ13C relationship. However, we did not observe such a clinal correlation pattern between height or δ13C and pest suitability. Further, we found that the study populations exhibiting functional tradeoffs or synergies to various degrees in test sites were driven by non-adaptive evolutionary processes rather than adaptive evolution or plasticity. Finally, we found positive genetic relationships between height and drought or pest resistance metrics and probed five loci showing potential genetic tradeoffs between northernmost and the other populations. Our findings have implications for deciphering the ecological, evolutionary, and genetic bases of the decoupling of functional tradeoffs due to environmental change.This work was funded by Genome Canada, Genome Alberta through Alberta Economic Trade and evelopment, Genome British Columbia, the University of Alberta, the University of Calgary, the University of Cambridge, and the Australian Research Council Centre of Excellence for Plant Success in Nature and Agriculture (CE200100015).Peer reviewe

The Karachi intracranial stenosis study (KISS) Protocol: an urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan.

Background: Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to intracranial stenosis. We aim to identify risk factors and biomarkers for intracranial stenosis and to develop techniques such as use of transcranial doppler to help diagnose intracranial stenosis in a cost-effective manner. Methods/Design: The Karachi Intracranial Stenosis Study (KISS) is a prospective, observational, case-control study to describe the clinical features and determine the risk factors of patients with stroke due to intracranial stenosis and compare them to those with stroke due to other etiologies as well as to unaffected individuals. We plan to recruit 200 patients with stroke due to intracranial stenosis and two control groups each of 150 matched individuals. The first set of controls will include patients with ischemic stroke that is due to other atherosclerotic mechanisms specifically lacunar and cardioembolic strokes. The second group will consist of stroke free individuals. Standardized interviews will be conducted to determine demographic, medical, social, and behavioral variables along with baseline medications. Mandatory procedures for inclusion in the study are clinical confirmation of stroke by a healthcare professional within 72 hours of onset, 12 lead electrocardiogram, and neuroimaging. In addition, lipid profile, serum glucose, creatinine and HbA1C will be measured in all participants. Ancillary tests will include carotid ultrasound, transcranial doppler and magnetic resonance or computed tomography angiogram to rule out concurrent carotid disease. Echocardiogram and other additional investigations will be performed at these centers at the discretion of the regional physicians. Discussion: The results of this study will help inform locally relevant clinical guidelines and effective public health and individual interventions

Isavuconazole for COVID-19-Associated Invasive Mold Infections

Isavuconazole is a broad-spectrum antifungal drug recently approved as a first-line treatment for invasive aspergillosis and as a first or alternative treatment for mucormycosis. The purpose of this review was to report and discuss the use of isavuconazole for the treatment of COVID-19-associated aspergillosis (CAPA), and COVID-19-associated mucormycosis (CAM). Among all studies which reported treatment of CAPA, approximately 10% of patients were reportedly treated with isavuconazole. Considering 14 identified studies that reported the use of isavuconazole for CAPA, isavuconazole was used in 40% of patients (95 of 235 treated patients), being first-line monotherapy in over half of them. We identified six studies that reported isavuconazole use in CAM, either alone or in combination therapy. Overall, isavuconazole was used as therapy in 13% of treated CAM patients, frequently as combination or sequential therapy. The use of isavuconazole in CAPA and CAM is complicated by the challenge of achieving adequate exposure in COVID-19 patients who are frequently obese and hospitalized in the ICU with concomitant renal replacement therapy (RRT) or extracorporeal membrane oxygenation (ECMO). The presence of data on high efficacy in the treatment of aspergillosis, lower potential for drug–drug interactions (DDIs) and for subtherapeutic levels, and no risk of QT prolongation compared to other mold-active azoles, better safety profile than voriconazole, and the possibility of using an intravenous formulation in the case of renal failure are the advantages of using isavuconazole in this setting

Academic and Workplace Buoyancy and its Association with Demographic Variables among Health Sciences’ Undergraduates

Academic buoyancy is important for influencing students’ ability to face academic challenges. It describes learners’ ability to defeat academic difficulties. It is an important factor on the psycho-educational landscape assisting students experiencing setbacks. Clinical/workplace buoyancy can help health sciences’ students to face the challenges in error-prone learning atmosphere. Objective: To assess the level of academic and workplace buoyancy and its association with demographic variables among health sciences’ undergraduates. Methods: Analytical cross-sectional research with convenient sampling was carried out on 222 undergraduates of Sohail University, Karachi. Ethical approval was taken from the ERC, Sohail University. Data were collected through Academic Buoyancy Scale. By using SPSS Version 25.0, the data were analyzed. Descriptive statistics were calculated and Chi-square was applied to observe the association of buoyancy with demographic variables. Results: In this study, mostly participants (98.6%) belong to the age 22-24 years. Over 50% of the partakers (55.9%) were females. All items of workplace and academic buoyancy had a significant association with study program (p-value 0.000, 0.010,0.002,0.021 respectively) while only 2 items showed significant association with study year (p-value 0.012 and 0.028). There was no significant association of buoyancy with variables like age, gender, religion and marital status. Conclusions: This study’s findings highlighted the buoyancy levels among health sector undergraduates. The association of buoyancy was found significant with study program and some items with CGPA and study year. These findings indicated the need to enhance positive traits like buoyancy among health sector undergraduates

Optimized Loading of Carboxymethyl Cellulose (CMC) in Tri-component Electrospun Nanofibers Having Uniform Morphology

Cellulose is one of the most hydrophilic polymers with sufficient water holding capacity but it is unstable in aqueous conditions and it swells. Cellulose itself is not suitable for electrospun nanofibers’ formation due to high swelling, viscosity, and lower conductivity. Carboxymethyl cellulose (CMC) is also super hydrophilic polymer, however it has the same trend for nanofibers formation as that of cellulose. Due to the above-stated reasons, applications of CMC are quite limited in nanotechnology. In recent research, loading of CMC was optimized for electrospun tri-component polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP), and carboxymethyl cellulose (CMC) nanofibers aim at widening its area of applications. PVA is a water-soluble polymer with a wide range of applications in water filtration, biomedical, and environmental engineering, and with the advantage of easy process ability. However, it was observed that only PVA was not sufficient to produce PVA/CMC nanofibers via electrospinning. To increase spinnability of PVA/CMC nanofibers, PVP was selected as the best available option because of its higher conductivity and water solubility. Weight ratios of CMC and PVP were optimized to produce uniform nanofibers with continuous production as well. It was observed that at a weight ratio of PVP 12 and CMC 3 was at the highest possible loading to produce smooth nanofibers