COMPARISON OF SOME BIOCHEMICAL VARIABLES DURING KICKBOXING COMPETITIONS

Background: Kickboxing is a high-intensity, intermittent combat sport, which is characterized by short-term complex abilities and tactical key movements. In this study, it was aimed to investigate the factors related to variability in potential biochemical parameters and competition behavior of high-level kickboxing athletes. Methods: Blood samples of athletes, which were obtained pre- and post-maximal competition applied in accordance with the period, were investigated. In the study, a total of 50 athletes, which consisted of 39 male and 11 female amateur athletes with a mean age of 20.08 ± 6.33. Results: Significant differences were determined in the Body Mass Index (BMI) values between females and males. It was determined that athletes’ Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), Total Oxidant Level (TOL) and Malondialdehyde (MDA) values were significantly increased pre- and post-competition while it was determined that Total Antioxidant Level (TAL) were significantly decreased (

SIRNAK PROVİNCE FİRST TRİMESTER PRENATAL SCREENİNG TEST CURRENT MEDİAN VALUES

Purpose: We aimed to compare the current median values of hormone levels used in screening tests performed during the first trimester in pregnant women in Şırnak with the medians of standard software used in hormone devices and to reveal the differences between them. Materials and Methods: In the study, the data of 301 pregnant women who applied to the hospital in Şırnak province between 01/05/2021 and 01/05/2022 were used by pulling prenatal dual screening test measurements from the hospital database after the hospital permission and ethics committee approval were obtained. The MoM levels found according to the median values calculated by the device software and the multiples of the medians (MoM) calculated according to the weekly median levels entered in the program were compared. Results: Current median levels of free β-HCG were found to be statistically significantly different and lower than those used in screening tests at 11, 12, and 13 weeks of gestation (p<0.01). Current median levels of PAPP-A were statistically significantly different from the software median levels of 11 and 12 weeks of gestation (p<0.01). Free β-HCG and PAPP-A Current MoM averages were statistically significantly different and lower than software MoM levels in both (p<0.01). Conclusion: In this study, it was discussed that comparative data using the current median and local levels of the calculations made to reveal the risk levels of risky pregnancies would also increase the importance and performance of prenatal screening tests

Effects of The Hydroxyurea Derivative 1, 3, 4- Thiadiazoles On Antioxidant Vitamins, MDA in Serums of Rats and Cell Viability of MCF-7 Breast Cancer Cells

In this study, the effects of as used ligand [1-hydroxy - 2 - (5 - (trifluoromethyl) - 1, 3, 4- thiadiazole- 2 - yl)guanidine] and its Mn, Cd, Cr complexes on the antioxidant vitamins and MDA levels in the serums of rats and antitumor activity of these chemical compounds on the MCF-7 breast cancer cells at different concentrations were investigated. When the results were compared between the levels of control and experimental groups of antioxidant vitamins ve MDA statistically, it was observed that there were decreased levels of A, E, and C vitamins in groups of applied Cd (II) and Cr (II) complexes compared with the control group, whereas MDA levels were increased. The antioxidant vitamins and MDA levels in serum were determined by HPLC.It was clearly observed that the subcutaneously MCF-7 breast cancer cells treated Ligand (L), Mn(L)2, Cd(L)2 and Cr(L)2 complexes had the low levels of cell viability activity when compared to the untreated control cells clearly increased according to the control group for after incubation 24 h onwards to 48 h. Cell vialities measured by electronic microscope. As a result, It suggested that thiadiazole compounds exhibit antitumor activity with reduction in serum antioxidant vitamins of rats can cause cytotoxic effect depending on the mechanism of oxidative damage

Investigation of the fatty acid amounts in the bee pollens of collected from Bingol’s flora

Bu çalışmada, Bingöl yöresinin beş farklı yerinden toplanan arı poleni örneklerindeki yağ asidi bileşenleri araştırıldı. Çalışmada beş farklı yerin her birinden 4 örnek olmak üzere toplam 20 örnek kullanıldı. Polen örnekleri estraksiyon işlemi yapıldı ve ekstraksiyonlar gaz kromatografisiyle analiz edildi. Analiz sonuçlarına göre, palmitik asit (C16:0), stearik asit (C18:0), oleik asit (C18:1n-9) ve γ – linolenik asit (C18:3n-6) miktarlarında istatistiksel olarak anlamlı bir fark (p<0.05) saptanırken, palmitoleik asit (C16:1n-7), linoleik asit (C18:2n-6), α – linolenik asit (C18:3n-3), toplam doymuş yağ asidi (SFA), toplam tekli doymamış yağ asidi (MUFA) ve toplam çoklu doymamış ( PUFA) yağ asidi miktarlarındaki farklılıklar istatistiksel olarak önemsiz bulundu (p>0.05). Sonuç olarak, polen örneklerindeki yağ asitlerinin doymamışlık oranının doymuşluğa oranına olan değerinin (TUFA/SFA) 1.57 - 1.92 arasında olduğu ve esansiyel yağ asitlerinden α – linolenik asit ve γ – linolenik asit karışımının toplam yağ asitlerinin yaklaşık % 33’ü ve linoleik asitin toplam yağ asitlerinin yaklaşık % 10’u olduğu saptandı. Bu araştırmayla bölgedeki polenlerin biyolojik değeri ve besin kalitesi hakkında bilgi edinilebileceği ve bu araştırma sonuçlarının literatür bilgisine katkıda bulunabileceği düşünülmektedirIn this study, fatty acid compounds in the bee pollens collected from five different locations of Bingöl were investigated. A total of 27 samples of polen, each 4 of which taken from 5 different places, were examined. Pollen samples were extracted and extractions were analyzed by gas choromatography (GC). According to results, while significant difference in the amount of palmitic acid (C16:0) and stearic acid (C18:0) oleic acid (C18:1n-9) and γ – linolenic acid (C18:3n-6) were found, the amounts of palmitoleic acid ( C16:1n-7), linoleic acid (C18:2n-6), α – linolenic acid (C18:3n-3), saturated fatty acids (SFA), monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) were not found significant (p>0.05). As a result, it was found that the unsaturated-to-saturated fatty acids ratio (TUFA/SFA ratio) in the pollen samples examined ranged from 1.57 to 1.92 and essential fatty acids appeared to be mixture of α-linolenic acid and γ- linolenic acid, 33% and linoleic acid 10 %, respectively of the total fatty acids. It can be thought that with this study one can get information about biological value and nutritional quality of the pollen grains in the this region and this investigation will have an important effect on improvement of the knowledge of that area

The comparison of some blood parameters of rainbow trout (Oncorhynchus mykiss Walbaum, 1792) in different rearing habitats

In this study, the effects of different rearing systems such as natural, cage and pond on blood parameters such as glucose (GLU), cholesterol (CHOL), triglyceride (TG), total protein (TP), albumin (ALB) , globulin (GLO), creatinine (CRE), uric acid (UA), urea and blood urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST) of rainbow trout (Oncorhynchus mykiss Walbaum, 1792) were compared and investigated the effects of different rearing systems on these parameters. Investigated biochemical blood parameters such as GLU, CHOL, TG, TP, ALB, GLO, CRE, ÜA, urea, BUN, ALT, AST values were statistically shown differences according to habitat.Bu çalışmada, havuz, kafes ve doğal olmak üzere üç farklı ortamda yetişen gökkuşağı alabalığı’ nın (Oncorhynchus mykiss Walbaum, 1792) glikoz (GLU), kolesterol (CHOL), trigliserit (TG), toplam protein (TP), albümin (ALB), globülin (GLO), kreatinin (CRE), ürik asit (ÜA), üre ve kan üre nitrojeni (BUN), alaninmaminotransferaz (ALT), aspartat aminotransferaz (AST) gibi kan parametrelerinin karşılaştırılması yapıldı ve farklı yetiştirme ortamlarının bu parametreler üzerine etkileri araştırıldı. İncelenen biyokimyasal kan parametrelerinden GLU, CHOL, TG, TP, ALB, GLO, CRE, ÜA, üre, BUN, ALT, AST değerlerinin yetişme ortamına göre istatistiksel olarak farklılık gösterdiği tespit edilmiştir

Farklı ortamlarda yetişen gökkuşağı alabalığı’ nın (Oncorhynchus mykiss Walbaum, 1792) bazı kan parametrelerinin karşılaştırılması

Bu çalışmada, havuz, kafes ve doğal olmak üzere üç farklı ortamda yetişen gökkuşağı alabalığı’ nın (Oncorhynchus mykiss Walbaum, 1792) glikoz (GLU), kolesterol (CHOL), trigliserit (TG), toplam protein (TP), albümin (ALB), globülin (GLO), kreatinin (CRE), ürik asit (ÜA), üre ve kan üre nitrojeni (BUN), alanin aminotransferaz (ALT), aspartat aminotransferaz (AST) gibi kan parametrelerinin karşılaştırılması yapıldı ve farklı yetiştirme ortamlarının bu parametreler üzerine etkileri araştırıldı. İncelenen biyokimyasal kan parametrelerinden GLU, CHOL, TG, TP, ALB, GLO, CRE, ÜA, üre, BUN, ALT, AST değerlerinin yetişme ortamına göre istatistiksel olarak farklılık gösterdiği tespit edilmiştir.In this study, the effects of different rearing systems such as natural, cage and pond on blood parameters such as glucose (GLU), cholesterol (CHOL), triglyceride (TG), total protein (TP), albumin (ALB) , globulin (GLO), creatinine (CRE), uric acid (UA), urea and blood urea nitrogen (BUN), alanine aminotransferase (ALT), aspartate aminotransferase (AST) of rainbow trout (Oncorhynchus mykiss Walbaum, 1792) were compared and investigated the effects of different rearing systems on these parameters. Investigated biochemical blood parameters such as GLU, CHOL, TG, TP, ALB, GLO, CRE, ÜA, urea, BUN, ALT, AST values were statistically shown differences according to habitat

Assessment of Anti-inflammatory and Antioxidant Properties of Safranal on CCI4-Induced Oxidative Stress and Inflammation in Rats

PubMed ID: 31141017The present study aimed to determine the antioxidative and anti-inflammatory effects of safranal on damage induced by CCl4. Experimental animals were divided into five groups. The first group was determined as the control group and no treatment was conducted. Second group rats were administered 1 mL/kg-day CCI4 during the experiment. Rats in Groups 3, 4 and 5 were administered 1 mL/kg-day CCI4 and 25 mg/kg, 50 mg/kg; 100 mg/kg safranal, respectively via gavage. Oxidative-antioxidant parameters, liver function enzymes and inflammatory cytokine levels were determined in liver samples obtained from the rats. Data analysis demonstrated that oxidative stress and inflammation markers were significantly higher in CCI4 administered groups (p<0.05). Antioxidant parameters in high-dose safranal administered groups were not different when compared to the control group. Safranal had ameliorating effects on the increased liver function enzymes activities in CCI4 administered groups. In conclusion, it was observed that CCI4 administration led to hepatic damage and increased oxidative stress and inflammatory cytokine levels. It was observed that particularly high-dose administration of safranal promoted the antioxidant system. Safranal administration was not effective on IL-1? levels. However, high-dose (100 mg/kg) safranal was found to be inflammatory against TNF-? and IL-6 cytokines. In conclusion, it can be said that safranal has an anti-inflammatory potential and has a strong antioxidative effect

Investigation of biological effects of some Mannich Bases containing Bis-1,2,4- Triazole

In this study, the effects of Mannich bases containing bis-1,2,4-triazole on the levels of in vivo malondialdehyde (MDA) and antioxidant vitamins (A, E, C) were examined in serum, livers and kidneys of rats. DA and vitamin (A, E, C) levels were determined by high performance liquid chromatography (HPLC). Antioxidant effect was investigated by determining the MDA levels in Saccharomyces cerevisiae cells as in vitro. Furthermore, the antitumor effects of compounds were investigated against MCF-7 human breast cancer cells. Interrelations of results among control and compound groups were evaluated using SPSS statistical software package. As a result, some of the compounds showed effective biological activity when compared to control conditions. The test compounds used in this study may be effective for utilization in the selection and design of model compounds for further studies