Internalized HIV/AIDS-related Stigma in a Sample of HIV-positive People in Bangladesh

Internalized stigma among people living with HIV/AIDS (PLHA) is prevalent in Bangladesh. A better understanding of the effects of stigma on PLHA is required to reduce this and to minimize its harmful effects. This study employed a quantitative approach by conducting a survey with an aim to know the prevalence of internalized stigma and to identify the factors associated with internalized stigma among a sample of 238 PLHA (male=152 and female=86) in Bangladesh. The findings suggest that there is a significant difference between groups with the low and the high-internalized HIV/AIDS stigma in terms of both age and gender. The prevalence of internalized stigma varied according to the poverty status of PLHA. An exploratory factor analysis (EFA) found 10 of 15 items loaded highly on the three factors labelled self-acceptance, self-exclusion, and social withdrawal. About 68% of the PLHA felt ashamed, and 54% felt guilty because of their HIV status. More than half (87.5% male and 19.8% female) of the PLHA blamed themselves for their HIV status while many of them (38.2% male and 8.1% female) felt that they should be punished. The male PLHA more frequently chose to withdraw themselves from family and social gatherings compared to the female PLHA. They also experienced a higher level of internalized stigma compared to the female PLHA. The results suggest that the prevalence of internalized stigma is high in Bangladesh, and much needs to be done by different organizations working for and with the PLHA to reduce internalized stigma among this vulnerable group

Internalized HIV/AIDS-related Stigma in a Sample of HIV-positive People in Bangladesh

Internalized stigma among people living with HIV/AIDS (PLHA) is prevalent in Bangladesh. A better understanding of the effects of stigma on PLHA is required to reduce this and to minimize its harmful effects. This study employed a quantitative approach by conducting a survey with an aim to know the prevalence of internalized stigma and to identify the factors associated with internalized stigma among a sample of 238 PLHA (male=152 and female=86) in Bangladesh. The findings suggest that there is a significant difference between groups with the low- and the high-internalized HIV/AIDS stigma in terms of both age and gender. The prevalence of internalized stigma varied according to the poverty status of PLHA. An exploratory factor analysis (EFA) found 10 of 15 items loaded highly on the three factors labelled self-acceptance, self-exclusion, and social withdrawal. About 68% of the PLHA felt ashamed, and 54% felt guilty because of their HIV status. More than half (87.5% male and 19.8% female) of the PLHA blamed themselves for their HIV status while many of them (38.2% male and 8.1% female) felt that they should be punished. The male PLHA more frequently chose to withdraw themselves from family and social gatherings compared to the female PLHA. They also experienced a higher level of internalized stigma compared to the female PLHA. The results suggest that the prevalence of internalized stigma is high in Bangladesh, and much needs to be done by different organizations working for and with the PLHA to reduce internalized stigma among this vulnerable group

Analysis of Heat Transfer in Non-Coaxial Rotation of Newtonian Carbon Nanofluid Flow with Magnetohydrodynamics and Porosity Effects

The study analyzed the heat transfer of water-based carbon nanotubes in non-coaxial rotation flow affected by magnetohydrodynamics and porosity. Two types of CNTs have been considered; single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs). Partial differential equations are used to model the problem subjected to the initial and moving boundary conditions. Employing dimensionless variables transformed the system of equations into ordinary differential equations form. The resulting dimensionless equations are analytically solved for the closed form of temperature and velocity distributions. The obtained solutions are expressed in terms of a complementary function error. The impacts of the embedded parameters are graphically plotted in different graphs and are discussed in detail. The Nusselt number and skin friction are also evaluated. The temperature and velocity profiles have been determined to meet the initial and boundary conditions. An augment in the CNTs’ volume fraction increases both temperature and velocity of the nanofluid as well as enhances the rate of heat transport. SWCNTs provides high values of Nusselt number compared to MWCNTs. For verification, a comparison between the present solutions and a past study is conducted and achieved excellent agreement

Macro-Surface Modifications of Subsonic Flow on Airplane Winglets

Airplane winglets are used to improve the efficiency and noise or vibrations of fixed-wing aircraft. In this paper, the surface modification involves alteration on surface’s features to improve the performance of a product is being conducted. The surface modification was implemented on winglet surface in order to investigate whether the modified winglets provide better performance or not compared to the conventional wing designs. Two types of models were used which is a rectangular plane and airplane winglet, each with different types of surface modifications. For rectangular plane, four surfaces were introduced which is smooth plane, dimpled plane, riveted plane and extruded rivet plane. As for winglets, three surfaces were used which is the smooth winglet, dimpled winglet and riveted winglet. The parameters used for the simulations were based on the actual cruising flight and zero degree angle of attack. From the results, both show that the surface with rivets is better. The flow trajectories show that the flow velocity across riveted surface modified winglet is 5% higher than the smooth conventional winglet

Impact of Rapid Urbanization on the Rates of Infection by Vibrio cholerae O1 and Enterotoxigenic Escherichia coli in Dhaka, Bangladesh

Bangladesh is a country where acute dehydrating diarrhea or cholera is common and is seen at least two times every year and additionally in natural disasters. In addition cholera cases have increased in the country, especially in urban settings such as in the capital city, Dhaka, where the number of hospitalized patients with more severe disease has tremendously increased. In the present observation, we have concentrated on determining the occurrence of diarrhoea caused by the two most common bacterial agents V. cholerae O1 and enterotoxigenic Escherichia coli (ETEC) in a densely populated, disease prone area Mirpur in Dhaka for two years from March 2008 to February 2010. Stool or rectal specimens from diarrheal patients coming to the ICDDR,B hospital from Mirpur were tested for the two bacterial pathogens. We found that V. cholerae O1 was the major bacterial pathogen and a cause of severe cholera disease in 23% of patients (2,647 of a total of 11,395 patients) from Mirpur. We surmise that cholera vaccines, as well as other public health tools that can target such high risk groups in the country, will be able to reduce the disease morbidity and the transmission of pathogens to improve the quality of life in urban settings

Risk factors for Coronavirus disease 2019 (Covid-19) death in a population cohort study from the Western Cape province, South Africa

Risk factors for coronavirus disease 2019 (COVID-19) death in sub-Saharan Africa and the effects of human immunodeficiency virus (HIV) and tuberculosis on COVID-19 outcomes are unknown. We conducted a population cohort study using linked data from adults attending public-sector health facilities in the Western Cape, South Africa. We used Cox proportional hazards models, adjusted for age, sex, location, and comorbidities, to examine the associations between HIV, tuberculosis, and COVID-19 death from 1 March to 9 June 2020 among (1) public-sector “active patients” (≥1 visit in the 3 years before March 2020); (2) laboratory-diagnosed COVID-19 cases; and (3) hospitalized COVID-19 cases. We calculated the standardized mortality ratio (SMR) for COVID-19, comparing adults living with and without HIV using modeled population estimates.Among 3 460 932 patients (16% living with HIV), 22 308 were diagnosed with COVID-19, of whom 625 died. COVID19 death was associated with male sex, increasing age, diabetes, hypertension, and chronic kidney disease. HIV was associated with COVID-19 mortality (adjusted hazard ratio [aHR], 2.14; 95% confidence interval [CI], 1.70–2.70), with similar risks across strata of viral loads and immunosuppression. Current and previous diagnoses of tuberculosis were associated with COVID-19 death (aHR, 2.70 [95% CI, 1.81–4.04] and 1.51 [95% CI, 1.18–1.93], respectively). The SMR for COVID-19 death associated with HIV was 2.39 (95% CI, 1.96–2.86); population attributable fraction 8.5% (95% CI, 6.1–11.1)

Analysis of flows and prediction of CH10 airfoil for unmanned arial vehicle wing design

The unmanned aerial vehicle (UAV) is becoming popular in the last two decades and it has been utilizing in enormous applications such as aerial monitoring, military purposes, rescue missions, etc. Hence, the present work focused on the design of the UAV wing considering the CH10 airfoil. In this paper, the computational fluid dynamic analysis on CH10 cambered airfoil has been conducted to achieve the preliminary results on the aerodynamic lift and drag coefficients. The airfoil has a chord length of 1 meter and has been subjected to low Reynolds numbers of 500 000, which is the standard operating Reynolds number for UAV wing design. The C-type fluid domain has been constructed at 30C upstream and downstream of the airfoil to initialize the boundary conditions. The angle of attack ranging from 0° to 14° with the increment of 2° has been done by changing the direction of the freestream velocity. The aerodynamic characteristics have been numerically computed using Spallart-Allmaras and Transient SST models. The aerodynamic coefficients achieved by these two models have been validated based on the XFOIL data. The contours of static pressure and velocity magnitude at 0°, 5°, 10°, and 12° the angle of attack has been portrayed. The static pressure distribution around the airfoil has been visually observed to analyze its influence on the aerodynamic coefficients. The velocity magnitude relation to the static pressure distribution has been approved based on Bernoulli’s equation such that increasing velocity magnitude has decreased the static pressure. The present results show that the Transient SST model has shown better flow prediction for an airfoil subjected to low Reynolds number flow

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease

Abstract Coumarins are the phytochemicals, which belong to the family of benzopyrone, that display interesting pharmacological properties. Several natural, synthetic and semisynthetic coumarin derivatives have been discovered in decades for their applicability as lead structures as drugs. Coumarin based conjugates have been described as potential AChE, BuChE, MAO and β-amyloid inhibitors. Therefore, the objective of this review is to focus on the construction of these pharmacologically important coumarin analogues with anti-Alzheimer’s activities, highlight their docking studies and structure–activity relationships based on their substitution pattern with respect to the selected positions on the chromen ring by emphasising on the research reports conducted in between year 1968 to 2017

Unsteady free convection flow of water-based carbon nanotubes due to non-coaxial rotations of moving disk

Nanofluid is one of the significant developments for having an efficient heat transport process. Its implementation in a non-coaxial rotating system has benefited from designing a mixer machine with two stirrer blades, cooling fan, and jet engines. This study analytically investigates the free convection of unsteady non-coaxial rotating nanofluid flow through a moving disk. The suspension of single-wall or multi-wall carbon nanotubes in water is known as the nanofluid in this study. The fluid motion is affected by the effects of rotation and buoyancy forces. Using suitable dimensionless variables, the dimensional coupled partial differential of momentum and energy equations along with their initial and moving boundary conditions are converted into the dimensionless form. The expressions for temperature and velocity profiles are obtained by solving governing equations using Laplace transform method. The validity of obtained solution is confirmed by having a good agreement when comparing present results with the published result. The results show that the insertion of CNTs particles into the rotating water causes the temperature and velocity profiles to increase. The amount of heat transferred by SWCNTs is greater than MWCNTs. Increasing CNTs particles has descended both primary and secondary skin friction but increase Nusselt number. Further analysis with the help of pictorial discussion for the fluid flows and heat transfer under the influences of nanoparticle volume fraction, Grashof number, the amplitude of disk, and time is carried out