A Prediction of the B*_c mass in full lattice QCD

By using the Highly Improved Staggered Quark formalism to handle charm, strange and light valence quarks in full lattice QCD, and NRQCD to handle bottom valence quarks we are able to determine accurately ratios of the B meson vector-pseudoscalar mass splittings, in particular, (m(B*_c)-m(B_c))/(m(B*_s)-m(B_s)). We find this ratio to be 1.15(15), showing the `light' quark mass dependence of this splitting to be very small. Hence we predict m(B_c*) = 6.330(7)(2)(6) GeV where the first two errors are from the lattice calculation and the third from existing experiment. This is the most accurate prediction of a gold-plated hadron mass from lattice QCD to date.Comment: 4 pages, 2 figure

Visualizing the emergence of the pseudogap state and the evolution to superconductivity in a lightly hole-doped Mott insulator

Superconductivity emerges from the cuprate antiferromagnetic Mott state with hole doping. The resulting electronic structure is not understood, although changes in the state of oxygen atoms appear paramount. Hole doping first destroys the Mott state yielding a weak insulator where electrons localize only at low temperatures without a full energy gap. At higher doping, the 'pseudogap', a weakly conducting state with an anisotropic energy gap and intra-unit-cell breaking of 90\degree-rotational (C4v) symmetry appears. However, a direct visualization of the emergence of these phenomena with increasing hole density has never been achieved. Here we report atomic-scale imaging of electronic structure evolution from the weak-insulator through the emergence of the pseudogap to the superconducting state in Ca2-xNaxCuO2Cl2. The spectral signature of the pseudogap emerges at lowest doping from a weakly insulating but C4v-symmetric matrix exhibiting a distinct spectral shape. At slightly higher hole-density, nanoscale regions exhibiting pseudogap spectra and 180\degree-rotational (C2v) symmetry form unidirectional clusters within the C4v-symmetric matrix. Thus, hole-doping proceeds by the appearance of nanoscale clusters of localized holes within which the broken-symmetry pseudogap state is stabilized. A fundamentally two-component electronic structure11 then exists in Ca2-xNaxCuO2Cl2 until the C2v-symmetric clusters touch at higher doping, and the long-range superconductivity appears.Comment: See the Nature Physics website for the published version available at http://dx.doi.org/10.1038/Nphys232

Engaging cervical spinal circuitry with non-invasive spinal stimulation and buspirone to restore hand function in chronic motor complete patients

© 2018, The Author(s). The combined effects of cervical electrical stimulation alone or in combination with the monoaminergic agonist buspirone on upper limb motor function were determined in six subjects with motor complete (AIS B) injury at C5 or above and more than one year from time of injury. Voluntary upper limb function was evaluated through measures of controlled hand contraction, handgrip force production, dexterity measures, and validated clinical assessment batteries. Repeated measure analysis of variance was used to evaluate functional metrics, EMG amplitude, and changes in mean grip strength. In aggregate, mean hand strength increased by greater than 300% with transcutaneous electrical stimulation and buspirone while a corresponding clinically significant improvement was observed in upper extremity motor scores and the action research arm test. Some functional improvements persisted for an extended period after the study interventions were discontinued. We demonstrate that, with these novel interventions, cervical spinal circuitry can be neuromodulated to improve volitional control of hand function in tetraplegic subjects. The potential impact of these findings on individuals with upper limb paralysis could be dramatic functionally, psychologically, and economically

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with progression of fibrosis. However, the cellular origins of these mesenchymal phenotypes remain unclear. We examined whether the potent fibrogenic cytokine TGF-β1 could induce epithelial mesenchymal transition (EMT) in the human alveolar epithelial cell line, A549, and investigated the signaling pathway of TGF-β1-mediated EMT. Methods: A549 cells were examined for evidence of EMT after treatment with TGF-β1. EMT was assessed by: morphology under phase-contrast microscopy; Western analysis of cell lysates for expression of mesenchymal phenotypic markers including fibronectin EDA (Fn-EDA), and expression of epithelial phenotypic markers including E-cadherin (E-cad). Markers of fibrogenesis, including collagens and connective tissue growth factor (CTGF) were also evaluated by measuring mRNA level using RT-PCR, and protein by immunofluorescence or Western blotting. Signaling pathways for EMT were characterized by Western analysis of cell lysates using monoclonal antibodies to detect phosphorylated Erk1/2 and Smad2 after TGF-β1 treatment in the presence or absence of MEK inhibitors. The role of Smad2 in TGF-β1-mediated EMT was investigated using siRNA. Results: The data showed that TGF-β1, but not TNF-α or IL-1β, induced A549 cells with an alveolar epithelial type II cell phenotype to undergo EMT in a time-and concentration-dependent manner. The process of EMT was accompanied by morphological alteration and expression of the fibroblast phenotypic markers Fn-EDA and vimentin, concomitant with a downregulation of the epithelial phenotype marker E-cad. Furthermore, cells that had undergone EMT showed enhanced expression of markers of fibrogenesis including collagens type I and III and CTGF. MMP-2 expression was also evidenced. TGF-β1-induced EMT occurred through phosphorylation of Smad2 and was inhibited by Smad2 gene silencing; MEK inhibitors failed to attenuate either EMT-associated Smad2 phosphorylation or the observed phenotypic changes. Conclusion: Our study shows that TGF-β1 induces A549 alveolar epithelial cells to undergo EMT via Smad2 activation. Our data support the concept of EMT in lung epithelial cells, and suggest the need for further studies to investigate the phenomenon

Characterization of Moment of Inertia Variations by Holographic Interferometry

Holographic interferometry (HI) is a powerful tool for mapping of surface defects. In conjunction with various stressing techniques [l–4], it offers an NDT tool for the detection of flaws within the volume of materials. The method is advantageous for integrity characterization of components to serve under mechanical stress, where the detailed shape, size and depth of the flaw within the material are of no interest. For most applications, where integrity is tested, the moment of inertia may be used as a measure for classification of the product and for the estimation of its reliability. The presence of volumetric flaws, when the sample is under loading, is expressed in the holographic interferogram. The exterma of the fringe pattern are used for determination of the displacement distribution. The second derivative of the displacement distribution is related to the bending moment and the moment of inertia. The moment of inertia may be further processed to obtain a function free from degrading influence of the specific measuring system employed [5]

Dp-branes, NS5-branes and U-duality from nonabelian (2,0) theory with Lie 3-algebra

We derive the super Yang-Mills action of Dp-branes on a torus T^{p-4} from the nonabelian (2,0) theory with Lie 3-algebra. Our realization is based on Lie 3-algebra with pairs of Lorentzian metric generators. The resultant theory then has negative norm modes, but it results in a unitary theory by setting VEV's of these modes. This procedure corresponds to the torus compactification, therefore by taking a transformation which is equivalent to T-duality, the Dp-brane action is obtained. We also study type IIA/IIB NS5-brane and Kaluza-Klein monopole systems by taking other VEV assignments. Such various compactifications can be realized in the nonabelian (2,0) theory, since both longitudinal and transverse directions can be compactified, which is different from the BLG theory. We finally discuss U-duality among these branes, and show that most of the moduli parameters in U-duality group are recovered. Especially in D5-brane case, the whole U-duality relation is properly reproduced.Comment: 1+26 page

Proposed New Antiproton Experiments at Fermilab

Fermilab operates the world's most intense source of antiprotons. Recently various experiments have been proposed that can use those antiprotons either parasitically during Tevatron Collider running or after the Tevatron Collider finishes in about 2010. We discuss the physics goals and prospects of the proposed experiments.Comment: 6 pages, 2 figures, to appear in Proceedings of IXth International Conference on Low Energy Antiproton Physics (LEAP'08), Vienna, Austria, September 16 to 19, 200

A consistent picture for large penguins in D -> pi+ pi-, K+ K-

A long-standing puzzle in charm physics is the large difference between the D0 -> K+ K- and D0 -> pi+ pi- decay rates. Recently, the LHCb and CDF collaborations reported a surprisingly large difference between the direct CP asymmetries, Delta A_CP, in these two modes. We show that the two puzzles are naturally related in the Standard Model via s- and d-quark "penguin contractions". Their sum gives rise to Delta A_CP, while their difference contributes to the two branching ratios with opposite sign. Assuming nominal SU(3) breaking, a U-spin fit to the D0 -> K+ pi-, pi+ K-, pi+ pi-, K+ K- decay rates yields large penguin contractions that naturally explain Delta A_CP. Expectations for the individual CP asymmetries are also discussed.Comment: 24 pages, 8 figure

Development of a generic activities model of command and control

This paper reports on five different models of command and control. Four different models are reviewed: a process model, a contextual control model, a decision ladder model and a functional model. Further to this, command and control activities are analysed in three distinct domains: armed forces, emergency services and civilian services. From this analysis, taxonomies of command and control activities are developed that give rise to an activities model of command and control. This model will be used to guide further research into technological support of command and control activities