The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one

In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice. We here highlight and discuss the need to take advantage of the common immune targets to design combined strategies to increase clinical responses

IMPA versus Cloud Analysis and IDA: Different Methods to Evaluate Structural Seismic Fragility

Well-known methods for seismic performance assessment, such as incremental dynamic analysis (IDA), multi-stripes analysis (MSA) and the cloud method, involve nonlinear response time-history analyses to characterize the relationship between the chosen damage measure versus intensity measure. Over the past two decades, many authors have proposed simplified procedures or nonlinear static approaches to develop fragility. In these procedures, the capacity of the system is evaluated by nonlinear static procedures (i.e., the capacity spectrum method (CSM), the N2 method, modal pushover analysis (MPA)) and the demand is derived by response spectra. In addition to the familiar ones, incremental modal pushover analysis (IMPA) is a novel nonlinear static procedure proposed in recent years, and it is used in this research to present an IM-based fragility estimation. The accuracy and effectiveness of different methods to assess vulnerability are investigated by comparing fragility curves derived by MPA-based cloud analysis, IMPA and cloud analysis against IDA. The comparison gives valuable insights on the influence of scaling on different sets of records; however, a more extended validation is needed to confirm the obtained results and draw more general conclusions. Results arise from two relatively small bins of record motions differing by ranges of Joyner-Boore distance and scattered in a range of magnitude are presented

Commissioning of a Novel Test Apparatus for the Identification of the Dynamic Coefficients of Large Tilting Pad Journal Bearings

This paper describes the commissioning of a novel test bench for the static and dynamic characterization of large tilting pad journal bearings, realized within a collaboration of the Department of Civil and Industrial Engineering of the University of Pisa, BHGE and AM Testing. The adopted test bench configuration has the test article (TA) floating at the mid-span of a rotor supported by two rolling bearings. The TA is statically loaded vertically upwards by a hydraulic actuator and excited dynamically by two orthogonal hydraulic actuators with multiple frequency sinusoidal forces. The test rig is capable of testing bearings with a diameter from 150 to 300 mm. It includes very complex mechanical, hydraulic, electrical and electronic components, and needs, for the whole plant, about 1 MW of electric power. The commissioning of the testing system involved several aspects and presented various issues. This work focuses on measuring systems and data acquisition of high-frequency data (forces, accelerations and relative displacements) and on data processing for the identification of the bearing dynamic coefficients. The identification procedure is based on the linearity assumption and the principle of superposition, operating in the frequency domain with the fast Fourier transforms of the applied forces and displacement signals. First results, referred to a 4-pad bearing, are in satisfactory agreement with theoretical ones

Simultaneous sinus lift and implant placement using lateral approach in atrophic posterior maxilla with residual bone height of 5 mm or less. A systematic review

Aim To test both success and survival rate of implant placed simultaneously with sinus lift in atro-phic posterior maxilla with a residual bone height of less than 5 mm. Materials and methods A computer search strategy was developed for the following electronic databases: MEDLINE/ PubMed and EMBASE. All the relevant articles were screened involving controlled clinical trials, randomized clinical trials, prospective cohort studies. Results The selection process yielded 12 studies, published between 1999 and 2016, 6 of which were prospective, 1 was a randomized controlled trial, 5 were controlled studies. Conclusions Within the limitation of this systematic review, the qualitative data analysis revealed that the survival rate of implants placed in grafted sinus ranged from 61% to 100%; on the other hand, the success rate ranged between 75.3% to 94.8%. No significant differences were detected regarding different grafting materials used. In order to understand if the one-stage pro-cedure is an effective and predictable surgical alternative in critically resorbed maxillae, larger and well designed clinical trials are needed

Let me Google that for you:a time series analysis of seasonality in internet search trends for terms related to foot and ankle pain

BACKGROUND: The analysis of internet search traffic may present the opportunity to gain insights into general trends and patterns in information seeking behaviour related to medical conditions at a population level. For prevalent and widespread problems such as foot and ankle pain, this information has the potential to improve our understanding of seasonality and trends within these conditions and their treatments, and may act as a useful proxy for their true incidence/prevalence characteristics. This study aimed to explore seasonal effects, general trends and relative popularity of internet search terms related to foot and ankle pain over the past decade. METHODS: We used the Google Trends tool to obtain relative search engine traffic for terms relating to foot and ankle pain and common treatments from Google search and affiliated pages for major northern and southern hemisphere English speaking nations. Analysis of overall trends and seasonality including summer/winter differences was carried out on these terms. RESULTS: Searches relating to general foot pain were on average 3.4 times more common than those relating to ankle pain, and twice as common as searches relating to heel pain. Distinct seasonal effects were seen in the northern hemisphere, with large increases in search volumes in the summer months compared to winter for foot (p = 0.004, 95 % CI [22.2–32.1]), ankle (p = 0.0078, 95 % CI [20.9–35.5]), and heel pain (p = 0.004, 95 % CI [29.1–45.6]). These seasonal effects were reflected by data from Australia, with the exception of ankle pain. Annual seasonal effects for treatment options were limited to terms related to foot surgery and ankle orthoses (p = 0.031, 95 % CI [3.5–20.9]; p = 0.004, 95 % CI [7.6–25.2] respectively), again increasing in the summer months. CONCLUSIONS: A number of general trends and annual seasonal effects were found in time series internet search data for terms relating to foot and ankle pain. This data may provide insights into these conditions at population levels. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13047-015-0074-9) contains supplementary material, which is available to authorized users

Simultaneous sinus lift and implant placement using lateral approach in atrophic posterior maxilla with residual bone height of 5 mm or less. A systematic review

Aim To test both success and survival rate of implant placed simultaneously with sinus lift in atro-phic posterior maxilla with a residual bone height of less than 5 mm. Materials and methods A computer search strategy was developed for the following electronic databases: MEDLINE/ PubMed and EMBASE. All the relevant articles were screened involving controlled clinical trials, randomized clinical trials, prospective cohort studies. Results The selection process yielded 12 studies, published between 1999 and 2016, 6 of which were prospective, 1 was a randomized controlled trial, 5 were controlled studies. Conclusions Within the limitation of this systematic review, the qualitative data analysis revealed that the survival rate of implants placed in grafted sinus ranged from 61% to 100%; on the other hand, the success rate ranged between 75.3% to 94.8%. No significant differences were detected regarding different grafting materials used. In order to understand if the one-stage pro-cedure is an effective and predictable surgical alternative in critically resorbed maxillae, larger and well designed clinical trials are needed

Risk adjustment for inter-hospital comparison of caesarean delivery rates in low-risk deliveries

BACKGROUND: Caesarean delivery (CD) rates have been frequently used as quality measures for maternity service comparisons. More recently, primary CD rates (CD in women without previous CD) or CD rates within selected categories such as nulliparous, term, cephalic singleton deliveries (NTCS) have been used. The objective of this study is to determine the extent to which risk adjustment for clinical and socio-demographic variables is needed for inter-hospital comparisons of CD rates in women without previous CD and in NTCS deliveries. METHODS: Hospital discharge records of women who delivered in Emilia-Romagna Region (Italy) from January, 2007 to June 2009 and in Tuscany Region for year 2009 were linked with birth certificates. Adjusted RRs of CD in women without a previous Caesarean and NTCS were estimated using Poisson regression. Percentage differences in RR before and after adjustment were calculated and hospital rankings, based on crude and adjusted RRs, were examined. RESULTS: Adjusted RR differed substantially from crude RR in women without a previous Caesarean and only marginally in NTCS group. Hospital ranking was markedly affected by adjustment in women without a previous CD, but less in NTCS. CONCLUSION: Risk adjustment is warranted for inter-hospital comparisons of primary CD rates but not for NTCS CD rates. Crude NTCS CD rates are a reliable estimate of adjusted NTCS CD

Demography of the bottlenose dolphin Tursiops truncatus (Mammalia: Delphinidae) in the Eastern Ligurian Sea (NW Mediterranean): quantification of female reproductive parameters

AbstractThe reproductive histories of 41 adult bottlenose dolphin females were analysed using photo-identification data collected between 2006 and 2014 in four sub-areas of the eastern Ligurian Sea (northwest Mediterranean). The Rapallo sub-area revealed the highest (highly significant) frequency of encounters (per unit effort) of reproductive females in association with young individuals, therefore emerging as a candidate nursery area in the region. The estimated fertility rate of adult females ranged between 290 and 407 births per 1000 individuals per year, higher than that of other known bottlenose dolphin populations, with a calving interval between 2.45 and 3.5 years. These results will be useful for projecting future trends of this (sub)population