Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation

Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation and neuronal differentiation. However, the intracellular mechanisms underlying these effects of AChR signaling are not fully understood. It is known that activation of AChRs increase cellular proliferation and neurogenesis and that regulation of intracellular calcium through AChRs may underlie the many functions of ACh. Intriguingly, activation of diverse signaling molecules such as Ras-mitogen-activated protein kinase, phosphatidylinositol 3-kinase-Akt, protein kinase C and c-Src is modulated by AChRs. Here we discuss the roles of ACh in neuronal differentiation, cell proliferation and apoptosis. We also discuss the pathways involved in these processes, as well as the effects of novel endogenous AChRs agonists and strategies to enhance neuronal-differentiation of stem and neural progenitor cells. Further understanding of the intracellular mechanisms underlying AChR signaling may provide insights for novel therapeutic strategies, as abnormal AChR activity is present in many diseases

Relative deprivation and inequalities in social and political activism

In this paper we analyse whether relative deprivation has divergent effects on different types of social and political action. We expect that it will depress volunteering with parties as well as different types of conventional political participation more generally while stimulating volunteering with anti-cuts organisations and engagement in various kinds of protest activism. There is little research into how relative deprivation impacts on different types of social and political action from the wide range of activities available to citizens in contemporary democracies as well as into how this relationship might vary based on the wider economic context. While many studies construct scales, we examine participation in specific activities and associations, such as parties or anti-cuts organisations, voting, contacting, demonstrating and striking to show that deprivation has divergent effects that depart from what is traditionally argued. We apply random effects models with cross-level interactions utilizing an original cross-national European dataset collected in 2015 (N = 17,667) within a collaborative funded-project. We show that a negative economic context has a mobilizing effect by both increasing the stimulating effect of relative deprivation on protest activism as well as by closing or reversing the gap between resource-poor and resource-rich groups for volunteering with parties and voting

Intergroup Emotions: More than the Sum of the Parts

In this chapter we make the case that recent research on intergroup emotions enriches both the intergroup relations and emotions domains in a way that is more than the sum of its parts. Focusing on research from our own lab’ we illustrate our argument with evidence for the heuristic value of a group emotions approach to prejudice and discrimination, and to social action and social change on the part of disadvantaged groups. In terms of prejudice and discrimination, a group emotion based analysis helps us to understand the specificity and also extreme forms that (emotional) prejudice can take. We focus on the particularly powerful combination of anger and fear, and the explicitly malicious emotion of intergroup schadenfreude. As well as helping to explain examples of negative intergroup behavior, group emotions can also help to explain social change resulting from group inequalities. We review work from a dual path model of collective action and social change that incorporates efficacy and emotions-focused coping routes to social change. Overall, there is strong evidence that group emotions are functional (if not always prosocial) in regulating behavior at the group level by validating shared experience in the group that becomes a launch-pad for action

Reactions to Crime as a Hierarchy Regulating Strategy : The Moderating Role of Social Dominance Orientation

Across two studies, we demonstrated that support for group-based hierarchies differentially affects evaluation of ingroup and outgroup criminal offenders and that this effect generalizes to overall evaluations of their respective groups. Drawing on social dominance theory, our results show that differential judgments of national ingroup and immigrant outgroup offenders reflect hierarchy regulating strategies. Study 1 (N = 94) revealed that egalitarians (low on SDO) were more lenient toward outgroup offenders and their ethnic group (Arab immigrants) when compared to ingroup offenders and their national group (Swiss citizens). The opposite was true for social dominators (high on SDO). Study 2 (N = 88) replicated the results of Study 1 and further demonstrated that the socio-economic status of the perpetrator did not affect perpetrator group evaluations suggesting that the arbitrary sets of ethnicity or nationality, not education level and employment status, were the important cues for hierarchy-regulating judgments of criminal offenders.Psycholog