Pain in platin-induced neuropathies: A systematic review and meta-analysis

INTRODUCTION: Platin-induced peripheral neuropathy (PIPN) is a common cause of PN in cancer patients. The aim of this paper is to systematically review the current literature regarding PIPN, with a particular focus on epidemiological and clinical characteristics of painful PIPN, and to discuss relevant management strategies. METHODS: A systematic computer-based literature search was conducted on the PubMed database. RESULTS: This search strategy resulted in the identification of 353 articles. After the eligibility assessment, 282 articles were excluded. An additional 24 papers were identified by scanning the reference lists. In total, 95 papers met the inclusion criteria and were used for this review. The prevalence of neuropathic symptoms due to acute toxicity of oxaliplatin was estimated at 84.6%, whereas PN established after chemotherapy with platins was estimated at 74.9%. Specifically regarding pain, the reported prevalence of pain due to acute toxicity of oxaliplatin was estimated at 55.6%, whereas the reported prevalence of chronic peripheral neuropathic pain in PIPN was estimated at 49.2%. CONCLUSION: Peripheral neuropathy is a common complication in patients receiving platins and can be particularly painful. There is significant heterogeneity among studies regarding the method for diagnosing peripheral neuropathy. Nerve conduction studies are the gold standard and should be performed in patients receiving platins and complaining of neuropathic symptoms post-treatment

Strategic Sourcing Toward a Sustainable Organic Coffee Supply Chain: A Research Applied in Cuzco

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.This paper is a research on recent studies on the importance of global supply chains from the perspective of farmers and suppliers. For the specific case of coffee in Peru, a survey model was used for assessing integration levels at the cooperatives in Quillabamba, Cusco, which revealed that the lack of alliances between first-level suppliers and farmers/cooperatives significantly affects sustainability in supply chain management. Therefore, this study proposes a strategic sourcing model where an intermediary integrates or strengthens the relationships between smallholders and improves interrelationships within the supply chain, thereby increasing productivity, yielding higher income, and improving product quality

Economic Aspects of Hybrid Cloud Infrastructure: User Organization Perspective

Adoption of cloud infrastructure promises enterprises numerous bene- ts, such as faster time-to-market and improved scalability enabled by on-demand provisioning of pooled and shared computing resources. In particular, hybrid clouds, by combining the private in-house capacity with the on-demand capacity of public clouds, promise to achieve both increased utilization rate of the in-house infrastructure and limited use of the more expensive public cloud, thereby lowering the total costs for a cloud user organization. In this paper, an analytical model of hybrid cloud costs is introduced, wherein the costs of computing and data communication are taken into account. Using this model, a cost-e cient division of the computing capacity between the private and the public portion of a hybrid cloud can be identi ed. By analyzing the model, it can be shown that, given xed prices for private and public capacity, a hybrid cloud incurs the minimum costs. Furthermore, it is shown that, as the volume of data transferred to/from the public cloud increases, a greater portion of the capacity should be allocated to the private cloud. Finally, the paper illustrates analytically that, when the unit price of capacity declines with the volume of acquired capacity, a hybrid cloud may become more expensive than a private or a public cloud.peerReviewe

Developing technologically induced environments:The case of the Nigerian banking sector

This paper addresses issues regarding prevalent values and themes in technologically induced environments in terms of planning, development, and implementation. Emerging themes (efficiency, usability, control, and security) are debated and developed in relation to underpinning values (quality, education, and reach/concern) which provide a comprehension of technological adoption in the developing economy of Nigeria. In addition, problems relating to new product development, innovation processes, synthesising marketing technologies, and strategic planning are investigated and explored. Discussion on technological adoption and use produces diverse perspectives and interpretations, which consequently prompts questions on its nature and understanding in developing societies. Assessing life-world perspectives and interpretations through phenomenological hermeneutics and consumer and communication models this study examines levels of technologically induced customer services in the banking services sector from a Nigerian perspective