1,730 research outputs found
ADAR enzyme and miRNA story: A nucleotide that can make the difference
Adenosine deaminase acting on RNA (ADAR) enzymes convert adenosine (A) to inosine (I) in double-stranded (ds) RNAs. Since Inosine is read as Guanosine, the biological consequence of ADAR enzyme activity is an A/G conversion within RNA molecules. A-to-I editing events can occur on both coding and non-coding RNAs, including microRNAs (miRNAs), which are small regulatory RNAs of ~20-23 nucleotides that regulate several cell processes by annealing to target mRNAs and inhibiting their translation. Both miRNA precursors and mature miRNAs undergo A-to-I RNA editing, affecting the miRNA maturation process and activity. ADARs can also edit 3' UTR of mRNAs, further increasing the interplay between mRNA targets and miRNAs. In this review, we provide a general overview of the ADAR enzymes and their mechanisms of action as well as miRNA processing and function. We then review the more recent findings about the impact of ADAR-mediated activity on the miRNA pathway in terms of biogenesis, target recognition, and gene expression regulation
The chaotic behavior of the black hole system GRS 1915+105
A modified non-linear time series analysis technique, which computes the
correlation dimension , is used to analyze the X-ray light curves of the
black hole system GRS 1915+105 in all twelve temporal classes. For four of
these temporal classes saturates to which indicates that
the underlying dynamical mechanism is a low dimensional chaotic system. Of the
other eight classes, three show stochastic behavior while five show deviation
from randomness. The light curves for four classes which depict chaotic
behavior have the smallest ratio of the expected Poisson noise to the
variability () while those for the three classes which depict
stochastic behavior is the highest (). This suggests that the temporal
behavior of the black hole system is governed by a low dimensional chaotic
system, whose nature is detectable only when the Poisson fluctuations are much
smaller than the variability.Comment: Accepted for publication in Astrophysical Journa
Dynamical response of the "GGG" rotor to test the Equivalence Principle: theory, simulation and experiment. Part I: the normal modes
Recent theoretical work suggests that violation of the Equivalence Principle
might be revealed in a measurement of the fractional differential acceleration
between two test bodies -of different composition, falling in the
gravitational field of a source mass- if the measurement is made to the level
of or better. This being within the reach of ground based
experiments, gives them a new impetus. However, while slowly rotating torsion
balances in ground laboratories are close to reaching this level, only an
experiment performed in low orbit around the Earth is likely to provide a much
better accuracy.
We report on the progress made with the "Galileo Galilei on the Ground" (GGG)
experiment, which aims to compete with torsion balances using an instrument
design also capable of being converted into a much higher sensitivity space
test.
In the present and following paper (Part I and Part II), we demonstrate that
the dynamical response of the GGG differential accelerometer set into
supercritical rotation -in particular its normal modes (Part I) and rejection
of common mode effects (Part II)- can be predicted by means of a simple but
effective model that embodies all the relevant physics. Analytical solutions
are obtained under special limits, which provide the theoretical understanding.
A simulation environment is set up, obtaining quantitative agreement with the
available experimental data on the frequencies of the normal modes, and on the
whirling behavior. This is a needed and reliable tool for controlling and
separating perturbative effects from the expected signal, as well as for
planning the optimization of the apparatus.Comment: Accepted for publication by "Review of Scientific Instruments" on Jan
16, 2006. 16 2-column pages, 9 figure
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies.
AIMS:
Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression. The association of PNPLA3 with advanced disease has been consistently demonstrated but many other modifier genes remain unidentified. In NAFLD, increased fatty acid oxidation produces high levels of reactive oxygen species. Manganese-dependent superoxide dismutase (MnSOD), encoded by the SOD2 gene, plays an important role in protecting cells from oxidative stress. A common non-synonymous polymorphism in SOD2 (C47T; rs4880) is associated with decreased MnSOD mitochondrial targeting and activity making it a good candidate modifier of NAFLD severity.
METHODS:
The relevance of the SOD2 C47T polymorphism to fibrotic NAFLD was assessed by two complementary approaches: we sought preferential transmission of alleles from parents to affected children in 71 family trios and adopted a case-control approach to compare genotype frequencies in a cohort of 502 European NAFLD patients.
RESULTS:
In the family study, 55 families were informative. The T allele was transmitted on 47/76 (62%) possible occasions whereas the C allele was transmitted on only 29/76 (38%) occasions, p=0.038. In the case control study, the presence of advanced fibrosis (stage>1) increased with the number of T alleles, p=0.008 for trend. Multivariate analysis showed susceptibility to advanced fibrotic disease was determined by SOD2 genotype (OR 1.56 (95% CI 1.09-2.25), p=0.014), PNPLA3 genotype (p=0.041), type 2 diabetes mellitus (p=0.009) and histological severity of NASH (p=2.0×10(-16)).
CONCLUSIONS:
Carriage of the SOD2 C47T polymorphism is associated with more advanced fibrosis in NASH
Development status of a Laue lens project for gamma-ray astronomy
We report the status of the HAXTEL project, devoted to perform a design study
and the development of a Laue lens prototype. After a summary of the major
results of the design study, the approach adopted to develop a Demonstration
Model of a Laue lens is discussed, the set up described, and some results
presented.Comment: 11 pages, 11 figures, 2007 SPIE Conference on Optics for EUV, X-Ray,
and Gamma-Ray Astronomy II
The GRAAL high resolution BGO calorimeter and its energy calibration and monitoring system
We describe the electromagnetic calorimeter built for the GRAAL apparatus at
the ESRF. Its monitoring system is presented in detail. Results from tests and
the performance obtained during the first GRAAL experiments are given. The
energy calibration accuracy and stability reached is a small fraction of the
intrinsic detector resolution.Comment: 19 pages, 14 figures, submitted to Nuclear Instruments and Method
Extensive Sclerosing Mesenteritis of the Rectosigmoid Colon Associated with Erosive Colitis
Sclerosing mesenteritis is a rare, idiopatic, usually benign, inflammatory process of the mesenteric adipose tissue. The most common site of involvement is the small bowel mesentery. We present a case of sclerosing mesenteritis of the rectosigmoid colon as a cause of severe abdominal pain, abdominal obstruction, and ischemic colic mucosal lesions. Contrast enema, colonoscopy, angiography, and CT were the imaging modalities used. A 20 cm diameter, fibrotic mass causing extensive compression of rectosigmoid colon was found at laparotomy. Histological examination showed extended fibrosis, inflammatory cells infiltration, lipophages, and granulomas within the mesenteric adipose tissue associated with erosive colitis. Clinical presentation and treatment are discussed
Dispersion of elastic waves in a layer interacting with a Winkler foundation
ABSTRACT
Dispersion of plane harmonic waves in an elastic layer interacting with a one- or two-sided Winkler foundation is analyzed. The long-wave low-frequency polynomial approximations of the full transcendental dispersion relations are derived for a relatively soft foundation. The validity of the conventional engineering formulation of a Kirchhoff plate resting on an elastic foundation is investigated. It is shown that this formulation has to be refined near the cutoff frequency of bending waves. The associated near cutoff expansion is obtained for both cases. A simple explicit formula demonstrating veering of bending and extensional waves is presented for a one-sided foundation
Magnetar outbursts: an observational review
Transient outbursts from magnetars have shown to be a key property of their
emission, and one of the main way to discover new sources of this class. From
the discovery of the first transient event around 2003, we now count about a
dozen of outbursts, which increased the number of these strongly magnetic
neutron stars by a third in six years. Magnetar outbursts might involve their
multi-band emission resulting in an increased activity from radio to hard
X-ray, usually with a soft X-ray flux increasing by a factor of 10-1000 with
respect to the quiescent level. A connected X-ray spectral evolution is also
often observed, with a spectral softening during the outburst decay. The flux
decay times vary a lot from source to source, ranging from a few weeks to
several years, as also the decay law which can be exponential-like, a power-law
or even multiple power-laws can be required to model the flux decrease. We
review here on the latest observational results on the multi-band emission of
magnetars, and summarize one by one all the transient events which could be
studied to date from these sources.Comment: 34 pages, 6 figures. Chapter of the Springer Book ASSP 7395
"High-energy emission from pulsars and their systems", proceeding of the Sant
Cugat Forum on Astrophysics (12-16 April 2010). Review updated to January
201
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