5,107 research outputs found
Less but Better? Teaching Maths in Further Education and Collateral Growth
The paper presents and explores the experience of maths students studying in a context shaped by a core concept maths curriculum. The three vignettes that illuminate experience are drawn from a larger research project that worked with five teachers and 630 learners aged 16−18 in Further Education classrooms in England. Analysis involved distinguishing different understandings of being good at maths, different views of a good maths curriculum and identifying enablers and barriers to being a ‘successful’ maths student. Dewey’s ideas about focused experience and collateral learning were used to deepen this analysis. The paper reports a surprising finding. In some cases, students recognize the positive impact learning maths had on developing their wider human capabilities. Maths teachers in England, working in the context of ‘new public management’, may find reasons to take heart from the accounts of teaching and learning presented. For the international reader who is grappling with the challenge of reengaging maths students, the accounts of what matters to students could spur a reconsideration of priorities and practice
An introduction to the Princeton sailwing windmill
Specifically discussed is the sailwing windmill. The aerodynamic characteristics of the sailwing itself are presented in condensed form and its natural application to the wind machine is discussed. Past and present sailwing windmill configurations are shown and their relative merits are compared. A section on a future promising configuration is presented and its compatibility to advanced technology electrical machinery is briefly discussed. Also included is a short bibliography
Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis
Background
Vascular endothelial growth factor (VEGF) has neurotrophic activity which is mediated by its main agonist receptor, VEGFR2. Dysregulation of VEGF causes motor neurone degeneration in a mouse model of amyotrophic lateral sclerosis (ALS), and expression of VEGFR2 is reduced in motor neurones and spinal cord of patients with ALS.
Methods
We have screened the promoter region and 4 exonic regions of functional significance of the VEGFR2 gene in a UK population of patients with ALS, for mutations and polymorphisms that may affect expression or function of this VEGF receptor.
Results
No mutations were identified in the VEGFR2 gene. We found no association between polymorphisms in the regulatory regions of the VEGFR2 gene and ALS.
Conclusion
Mechanisms other than genetic variation may downregulate expression or function of the VEGFR2 receptor in patients with ALS
The UK NHS Economic Evaluation Database : Economic issues in evaluations of health technology
Objective: The U.K. NHS Economic Evaluation Database (EED) project is commissioned to identify papers on economic evaluations of health technologies and to disseminate their findings to NHS decision makers by means of structured abstracts that are available through a public database and the Cochrane Library. This paper discusses current issues relating to the economic aspects of producing NHS EED abstracts. Methods: A review of NHS EED was undertaken between 1994 and 1999 to determine the methodologies adopted and issues that influence the usefulness of economic evaluations. Methods adopted to improve the quality of NHS EED abstracts are also reported. Results: Eighty-five percent of NHS EED abstracts are cost-effectiveness analyses (CEAs), 9.3% are cost-utility analyses (CUAs), and only 1.4% are cost-benefit analyses (CBAs). Of the total abstracts, 65.9% are based on single studies, 19.5% on reviews, 3.9% on estimates of effectiveness, and 10.7% on combinations of these sources. Models are utilized in 16.7% of CEAs, 60.2% of CUAs, and 20% of CBAs. Analyses of CBA studies reveal a degree of misuse of well-established definitions. NHS EED internal control mechanisms are reported that provide a means of ensuring that abstracts are based on sound academic principles. Conclusions: Most economic evaluations are conducted by means of CEA, followed by CUA, while CBA accounts for an extreme minority of cases. Single studies form the principal source of effectiveness data, although models are widely used, principally in CUA. The structure of NHS EED abstracts provides decision makers with the principal results and an interpretation of the relative strengths and weaknesses of economic evaluations
Modeling quasar accretion disc temperature profiles
Microlensing observations indicate that quasar accretion discs have
half-light radii larger than expected from standard theoretical predictions
based on quasar fluxes or black hole masses. Blackburne and colleagues have
also found a very weak wavelength dependence of these half-light radii. We
consider disc temperature profile models that might match these observations.
Nixon and colleagues have suggested that misaligned accretion discs around
spinning black holes will be disrupted at radii small enough for the
Lense-Thirring torque to overcome the disc's viscous torque. Gas in precessing
annuli torn off a disc will spread radially and intersect with the remaining
disc, heating the disc at potentially large radii. However, if the intersection
occurs at an angle of more than a degree or so, highly supersonic collisions
will shock-heat the gas to a Compton temperature of T~10^7 K, and the spectral
energy distributions (SEDs) of discs with such shock-heated regions are poor
fits to observations of quasar SEDs. Torn discs where heating occurs in
intermittent weak shocks that occur whenever the intersection angle reaches a
tenth of a degree pose less of a conflict with observations, but do not have
significantly larger half-light radii than standard discs. We also study two
phenomenological disc temperature profile models. We find that discs with a
temperature spike at relatively large radii and lowered temperatures at radii
inside the spike yield improved and acceptable fits to microlensing sizes in
most cases. Such temperature profiles could in principle occur in sub-Keplerian
discs partially supported by magnetic pressure. However, such discs overpredict
the fluxes from quasars studied with microlensing except in the limit of
negligible continuum emission from radii inside the temperature spike.Comment: Submitted to MNRAS. Comments welcome. 20 pages, 5 figure
A comparison of the responses of mature and young clonal tea to drought.
To assist commercial producers with optimising the use of irrigation water, the
responses to drought of mature and young tea crops (22 and 5 years after field
planting respectively) were compared using data from two adjacent long-term
irrigation experiments in Southern Tanzania. Providing the maximum potential
soil water deficit was below about 400-500 mm for mature, and 200-250 mm for
young plants (clone 6/8), annual yields of dry tea from rainfed or partially
irrigated crops were similar to those from the corresponding well-watered crops.
At deficits greater than this, annual yields declined rapidly in young tea (up
to 22 kg (ha mm)-1) but relatively slowly in mature tea (up to 6.5 kg (ha mm)-
1). This apparent insensitivity of the mature crop to drought was due
principally to compensation that occurred during the rains for yield lost in the
dry season. Differences in dry matter distribution and shoot to root ratios
contributed to these contrasting responses. Thus, the total above ground dry
mass of well-irrigated, mature plants was about twice that for young plants.
Similarly, the total mass of structural roots (>1 mm diameter), to 3 m depth,
was four times greater in the mature crop than in the young crop and, for fine
roots (<1 mm diameter), eight times greater. The corresponding shoot to root
ratios (dry mass) were about 1:1 and 2:1 respectively. In addition, each unit
area of leaf in the canopy of a mature plant had six times more fine roots (by
weight) available to extract and supply water than did a young plant. Despite
the logistical benefits resulting from more even crop distribution during the
year when crops are fully irrigated, producers currently prefer to save water
and energy costs by allowing a substantial soil water deficit to develop prior
to the start of the rains, up to 250 mm in mature tea, knowing that yield
compensation will occur later
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