Myélome Multiple Du Sujet Jeune Révélé Par Un Plasmocytome Sacré: À Propos D’un Cas

Objectif : Les auteurs rapportent un cas de myélome multiple survenu chez un adulte jeune, révélé par un plasmocytome du sacrum. L’intérêt de cette observation est diagnostic car les tumeurs du sacrum chez le sujet jeune sont rares et posent un problème de diagnostic différentiel avec le chordome et les métastases osseuses. Par ailleurs, la détection des lésions osseuses myélomateuses, étape indispensable au moment du diagnostic, se fait plus facilement au scanner qu’avec la radiographie conventionnelle. Objective: The authorsreport a case of multiple myeloma in the young adult revealed by a sacrum’s plasmacytoma. The purpose of this observation is diagnostic because sacral tumors in young adult are rare and create an issue of differential diagnosis with the Chordoma and bone metastases. In addition, detecting myeloma bone lesions, an essential step at the time of diagnosis, is easier with CT-scan than traditional radiographies

Splenic lymphoma with villous lymphocytes: case report

We present the case of malignant Non-Hodgkin splenic lymphoma with villous lymphocytes regarded as atypical chronic lymphoid leukemia. This was a 62 years old male patient admitted in the Haematologic Department of Brazzaville Teaching Hospital for an enlarged spleen, anaemia and lymphocytosis. The initial abdominal CT noticed a homogenous splenomegaly and a large retroperitoneal tumour mass measuring 148 X 101mm. The initial count blood cell revealed a lymphocytosis with a lymphocyte count at 82 Giga/l, severe anaemia with a haemoglobin rate at 4.2g/dl, platelet count at 68 Giga/l. Peripheral smear examination showed irregular lymphoid cells with a homogenous distribution, condensed chromatin corresponding to villous lymphocytes. Immunophenotyping showed B lymphoid monotypic population cells positive for CD19, CD 20, and FMC7, moderately positive for CD23 and negative for CD5, CD43 and CD 79b. Therapeutically, combination chemotherapy RCVAD (Rituximab, Vincristin, Daunorubicin, Dexamethasone) give good clinical and haematological response. This report illustrates the need for excellent interdisciplinary collaboration and the interest of the cytology and immunophenotyping in the lymphoid proliferation management

Imatinib mesylate in chronic myelogenous leukemia: a Congolese experience

Background: Chronic myeloid leukemia is a clonal myeloproliferative disorder caused by reciprocal translocation t(9;22) that induces tyrosin kinase protein. Imatinib is a selective inhibitor of this protein.Objectives: To assess responses to imatinib and outcome of Congolese patients with chronic phase chronic myeloid leukemia.Design: retrospective study.Settings: Clinical Haematology unit of Teaching Hospital in Brazzaville, CongoSubjects: Newly diagnosed patients with chronic phase chronic myeloid leukemia treated with imatinib.Results: A total of 25 males and 14 females with a mean age of 36 years at time of the diagnosis were enrolled in the study. The mean duration of the illness was 11.4 months. Imatinib induced complete hematologic response at 3 months in 100%. Major cytogenetic response was noticed in 87.18%. After a median follow up of 12 months, chronic myeloid leukemia had not progressed to the accelerated or blastic phase in an estimated 91.8% of patients and 86.6% were alive.Conclusion: Imatinib is effective in newly chronic phase chronic myeloid leukemia patient even though cytogenetic response rate are lower in Africa than western countries population

Multifocal tuberculous osteomyelitis/osteochondritis of ribs in patient with sickle cell disease

Tuberculosis rib osteomyelitis is a rare clinical entity that is more prevalent in developing countries. We report the case of multifocal tuberculous osteomyelitis/osteochondritis of ribs on a 23 years old sickle cell female patient. This observation aims to raise the awareness of rib osteomyelitis for which mycobacterium tuberculosis is the first pathogen involved in the process in developing countries

Plasmocytome cutané secondaire révélant un myélome multiple: à propos d’un cas

Le plasmocytome cutané secondaire métastatique est une prolifération plasmocytaire multiple extramédullaire de localisation cutanée. Son diagnostic repose sur la mise en évidence d'une prolifération plasmocytaire maligne au niveau médullaire et cutané. Son apparition s'associe à un stade avancé du myélome et à un pronostic péjoratif.Pan African Medical Journal 2016; 2

Inventing Ethnicity and Identifies in Gabon. The case of Ongom (Bakele)

This article deals with the « fabrication » and fluidity of identities and ethnicity in Gabon since the precolonial period. It shows how a precolonial ethnic group called « Ongom » whose consciousness was kept alive by a series of symbols was progressively replaced by the « Bakele » ethnic group. This new ethnic group was a « création » of European travelers and explorers who extended the name « Bakele » to all the Ongom sub-groups across Gabon in the 19th century. This new ethnicity was crystallized by territorial divisions and the appointment of chiefs during the colonial period. But the Bakele ethnicity did not have a lasting life, because it was progressively disolved by the growing Gabonese national sentiment after the second World War. This sentiment was reinforced by social fusion and political integration of the Bongo regime in the postcolonial period. But, since the 1980's the Bakele ethnicity is being « refabricated » to perpetuate Bongo's political power.Cet article traite de « l'invention » et changement des identités et ethnicités au Gabon depuis la période précoloniale. Il montre comment l'ethnie précoloniale « Ongom », représentée par une gamme de symboles fut remplacée par un nouveau groupe ethnique appelé « Bakele ». Cette nouvelle « formation sociale » fut l'œuvre d'explorateurs et voyageurs européens, qui imposèrent cet ethnonyme à l'ensemble des sous-groupes Ongom dans le bassin de l'Ogooué au XIXe siècle. Le sentiment d'affiliation à ce groupe ethnique fut cristallisée par le pouvoir colonial qui assigna des territoirs spécifiques aux Bakele et leurs imposa des chefs. Mais l'ethnicité Bakele allait elle aussi disparaître avec la montée de la fièvre nationaliste d'après-guerre et les dynamiques économiques et sociales de la période postcoloniale. Mais on assiste depuis les années 80 à une « ré-invention » de l'ethnicité Bakele, attribuable à Omar Bongo s'efforçant de consolider et perpétuer son pouvoir politique.Ngolet François. Inventing Ethnicity and Identifies in Gabon. The case of Ongom (Bakele). In: Revue française d'histoire d'outre-mer, tome 85, n°321, 4e trimestre 1998. pp. 5-26