The ins and outs of nanoparticle technology in neurodegenerative diseases and cancer.

As we enter the twenty-first century, several therapies based on using nanoparticles (NPs) ranging in size 1 - 1000 nm have been successfully brought to the clinic to treat cancer, pain and infectious diseases. These therapies bring together the ability of NPs to target the delivery of drugs more precisely, to improve solubility, to prevent degradation, to improve their therapeutic index and to reduce the immune response. NPs come in all shapes and sizes, designed specifically for biomedical applications such as solid lipid polymers, liposomes, dendrimers, nanogels, and quantum dots. These NPs offer many attractive characteristics such as biological stability and biocompatibility, thus incorporating different biological or drug molecules. Among the major therapeutic challenges from neurological diseases through to cancer is the development of nanomaterials that are able to be effective against the disease. In the case of neurodegeneration, one of the most difficult areas to penetrate for drug discovery in the body is the central nervous system, protected by the blood-brain-barrier. Whilst in the case of cancer, the biggest problem is how to specifically target a tumor with sufficient drug without causing side effects or inducing resistance. A new generation of intelligent NPs are emerging for the treatment of human disease such as neurological disorders and cancer. The use of natural alternative therapy is an encouraging idea in drug discovery. To this end as we gain more knowledge into the biological function of exosomes, this will allow us to harness their potential as natural NPs in future therapeutics

Aspectos fitossanitários da viticultura na região Noroeste do Estado de São Paulo.

O objetivo deste trabalho foi realizar um levantamento e uma avaliação do perfil do produtor de uva de mesa da região de Jales, identificando os problemas fitossanitários enfrentados, bem como as tecnologias adotadas para o controle de pragas que ocorrem na cultura da videira dessa região.bitstream/item/84830/1/cot136.pd

Quantum walks with spatiotemporal fractal disorder

We investigate the transport and entanglement properties exhibited by quantum walks with coin operators concatenated in a space-time fractal structure. Inspired by recent developments in photonics, we choose the paradigmatic Sierpinski gasket. The 0-1 pattern of the fractal is mapped into an alternation of the generalized Hadamard-Fourier operators. In fulfilling the blank space on the analysis of the impact of disorder in quantum walk properties -- specifically, fractal deterministic disorder --, our results show a robust effect of entanglement enhancement as well as an interesting novel road to superdiffusive spreading with a tunable scaling exponent attaining effective ballistic diffusion. Namely, with this fractal approach it is possible to obtain an increase in quantum entanglement without jeopardizing spreading. Alongside those features, we analyze further properties such as the degree of interference and visibility. The present model corresponds to a new application of fractals in an experimentally feasible setting, namely the building block for the construction of photonic patterned structures.Comment: 16 pages, 9 figure

Quantum walks in two dimensions: controlling directional spreading with entangling coins and tunable disordered step operator

We study a 2-D disordered time-discrete quantum walk based on 1-D `generalized elephant quantum walk' where an entangling coin operator is assumed and which paves the way to a new set of properties. We show that considering a given disorder in one direction, it is possible to control the degree of spreading and entanglement in the other direction. This observation helps assert that the random quantum walks of this ilk serve as a controllable decoherence channel with the degree of randomness being the tunable parameter and highlight the role of dimensionality in quantum systems regarding information and transport.Comment: 16 pages, 19 figure

Optical and near-infrared observations of SN 2011dh - The first 100 days

We present optical and near-infrared (NIR) photometry and spectroscopy of the Type IIb supernova (SN) 2011dh for the first 100 days. We complement our extensive dataset with SWIFT ultra-violet (UV) and Spitzer mid-infrared (MIR) data to build a UV to MIR bolometric lightcurve using both photometric and spectroscopic data. Hydrodynamical modelling of the SN based on this bolometric lightcurve have been presented in Bersten (2012). We find that the absorption minimum for the hydrogen lines is never seen below ~11000 km/s but approaches this value as the lines get weaker. This suggests that the interface between the helium core and hydrogen rich envelope is located near this velocity in agreement with the Bersten et al. (2012) He4R270 ejecta model. Spectral modelling of the hydrogen lines using this ejecta model supports the conclusion and we find a hydrogen mass of 0.01-0.04 solar masses to be consistent with the observed spectral evolution. We estimate that the photosphere reaches the helium core at 5-7 days whereas the helium lines appear between ~10 and ~15 days, close to the photosphere and then move outward in velocity until ~40 days. This suggests that increasing non-thermal excitation due to decreasing optical depth for the gamma-rays is driving the early evolution of these lines. We also provide and discuss pre- and post-explosion observations of the SN site which shows a reduction by 75 percent in flux at the position of the yellow supergiant coincident with SN 2011dh. The B, V and r band decline rates of 0.0073, 0.0090 and 0.0053 mag/day respectively are consistent with the remaining flux being emitted by the SN. Hence we find that the star was indeed the progenitor of SN 2011dh as previously suggested by Maund et al. (2011) and which is also consistent with the results from the hydrodynamical modelling.Comment: 38 pages, 27 figures, 18 tables, accepted for publication by A&

8-year multicenter retrospective study on partial laminate veneers

Purpose: This retrospective study aimed to evaluate the survival and success rates of ceramic partial laminate veneers. Scanning electron microscopy was used to evaluate fractures and marginal defects. Methods: In total, 31 patients received 79 partial laminate veneers on the maxillary anterior teeth. After adhesive luting, restorations were evaluated by calibrated clinicians for up to eight years using modified United States Public Health Service (USPHS) criteria. In addition, epoxy resin replicas were fabricated from silicone impressions and analyzed using scanning electron microscopy. Survival analyses were performed using the Kaplan-Meier and log-rank tests (α = 0.05). Success was analyzed in percentages by comparing the baseline and last follow-up. Results: The cumulative survival rates were 100% after 1 year; 95.9% (SE 2.8%) after 5 years; and 61.4% (SE 25.3%) after 8 years. No significant differences (P &gt; 0.05) were observed between functional and non-functional restorations. Changes in the USPHS criteria evaluation were only observed for adaptation: 12.5% (SE 4.7%), marginal discoloration: 4.2% (SE 3.0%), color match: 4.2% (SE 3.0%), and fractures: 16.7% (SE 5.3%). Scanning electron microscopy evaluations revealed undetected initial cracks and deficiencies in the restorations. Conclusions: Partial laminate veneers displayed good survival rates during the long-term follow-up. The main problems observed were related to the quality of the margins, color mismatch, and restoration integrity. However, in most cases, restoration replacement was not required.</p

The beta Pictoris association: Catalog of photometric rotational periods of low-mass members and candidate members

We intended to compile the most complete catalog of bona fide members and candidate members of the beta Pictoris association, and to measure their rotation periods and basic properties from our own observations, public archives, and exploring the literature. We carried out a multi-observatories campaign to get our own photometric time series and collected all archived public photometric data time series for the stars in our catalog. Each time series was analyzed with the Lomb-Scargle and CLEAN periodograms to search for the stellar rotation periods. We complemented the measured rotational properties with detailed information on multiplicity, membership, and projected rotational velocity available in the literature and discussed star by star. We measured the rotation periods of 112 out of 117 among bona fide members and candidate members of the beta Pictoris association and, whenever possible, we also measured the luminosity, radius, and inclination of the stellar rotation axis. This represents to date the largest catalog of rotation periods of any young loose stellar association. We provided an extensive catalog of rotation periods together with other relevant basic properties useful to explore a number of open issues, such as the causes of spread of rotation periods among coeval stars, evolution of angular momentum, and lithium-rotation connection.Comment: Forthcoming article, Received: 20 June 2016 / Accepted: 09 September 2016; 40 pages, 2 figures. The online figures A1-A73 are available at CD