Gamow-Teller properties of the double beta-decay partners 116Cd(Sn) and 150Nd(Sm)

The two Gamow-Teller (GT) branches connecting the double-beta decay partners (116Cd, 116Sn) and (150Nd, 150Sm) with the intermediate nuclei 116In and 150Pm are studied within a microscopic approach based on a deformed proton-neutron quasiparticle random-phase approximation built on a Skyrme selfconsistent mean field with pairing correlations and spin-isospin residual forces. The results are compared with the experimental GT strength distributions extracted from charge-exchange reactions. Combining the two branches, the nuclear matrix elements for the two-neutrino double-beta decay are evaluated and compared to experimental values derived from the measured half-lives.Comment: 10 pages, 16 figure

Primary Coenzyme Q10 Deficiency

open4siCLINICAL CHARACTERISTICS: Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive multiple-system atrophy-like phenotype (neurodegeneration with autonomic failure and various combinations of parkinsonism and cerebellar ataxia, and pyramidal dysfunction); and dystonia, spasticity, seizures, and intellectual disability. Steroid-resistant nephrotic syndrome (SRNS), the hallmark renal manifestation, is often the initial manifestation either as isolated renal involvement that progresses to end-stage renal disease (ESRD), or associated with encephalopathy (seizures, stroke-like episodes, severe neurologic impairment) resulting in early death. Hypertrophic cardiomyopathy (HCM), retinopathy or optic atrophy, and sensorineural hearing loss can also be seen. DIAGNOSIS/TESTING: The diagnosis of primary CoQ10 deficiency in a proband is established by identification of biallelic pathogenic variants in one of the nine genes encoding proteins directly involved in the synthesis of coenzyme Q10 or by detection of reduced levels of CoQ10 (ubiquinone) in skeletal muscle or reduced activities of complex I+III and II+III of the mitochondrial respiratory chain on frozen muscle homogenates. MANAGEMENT: Treatment of manifestations: In individuals with primary CoQ10 deficiency early treatment with high-dose oral CoQ10 supplementation (ranging from 5 to 50 mg/kg/day) can limit disease progression and reverse some manifestations; however, established severe neurologic and/or renal damage cannot be reversed. ACE inhibitors may be used in combination with CoQ10 supplementation in persons with proteinuria; renal transplantation is an option for those with ESRD. Treatment of hypertrophic cardiomyopathy, retinopathy, and sensorineural hearing loss is per usual practice. Prevention of primary manifestations: Supplementation with high-dose oral CoQ10 can prevent progression of the renal disease and onset of neurologic manifestations. Surveillance: Periodic neurologic evaluation, urine analysis (for proteinuria) and renal function tests, ophthalmologic evaluation, and audiometry. Evaluation of relatives at risk: Presymptomatic diagnosis for the purpose of early treatment with CoQ10 supplementation is warranted for relatives at risk. GENETIC COUNSELING: Primary coenzyme Q10 deficiency is inherited in an autosomal recessive manner. At conception, each sib of an affected individual has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Carrier testing for at-risk relatives, prenatal testing for pregnancies at increased risk, and preimplantation genetic diagnosis are possible if the pathogenic variants in a family are known.openSalviati, L; Trevisson, E; Doimo, M; Navas, PSalviati, Leonardo; Trevisson, Eva; Doimo, Mara; Navas, P

Evaluación de la evidencia del tratamiento de las lesiones del ligamento cruzado anterior de la rodilla

Introducción: El aumento de la accidentalidad deportiva y viaria ha dado origen a un incremento de las lesiones de rodilla y en particular del ligamento cruzado anterior. La presencia de inestabilidades residuales, los cambios degenerativos de la articulación y las lesiones secundarias, han sido invocadas como razones para justificar una actitud intervencionista. No obstante, la incompleta consecución de los objetivos propuestos ha llevado a que la opción conservadora se siga manteniendo vigente. Objetivos: Analizar la evidencia científica existente en el cuerpo bibliográfico que aborda el tratamiento de las lesiones del LCA de la rodilla. Establecer si se cumplen las motivaciones que inducen la elección del tratamiento, en sus posibilidades quirúrgica o conservadora. Concluir una guía de recomendaciones a la hora de enfocar el tratamiento de estas lesiones. Material y Métodos: Se analiza la evidencia científica existente en la literatura encontrada sobre este tema. Se plantea la realización de un metaanálisis con los resultados aportados por otros autores en estudios seleccionados. Éstos deberán responder a unos criterios de estudios comparativos entre tratamiento quirúrgico y conservador con exigencias de ser estudios prospectivos y aleatorizados, con un seguimiento mínimo de siete años y que tuvieran en cuenta análisis de resultados en los que se incluyeran criterios objetivos, así como consideración de la evaluación subjetiva en cuanto a la satisfacción del enfermo. Resultados: No se ha encontrado ningún estudio que se ajustara exactamente a la propuesta realizada. Si que se han hallado dos trabajos secuenciales, de una evolución más corta de la exigida y en el que la comparación se hacía entre tres tratamientos de las lesiones del ligamento cruzado anterior, si bien ninguno de ellos era una opción totalmente conservadora y además empleaban unas técnicas de reconstrucción que en la actualidad tienen muy pocos seguidores dentro de los que defienden la opción quirúrgica, como es la sutura primaria del ligamento cruzado anterior deteriorado. Conclusiones: La opción que deja menos inestabilidad residual es la realización de sutura directa del LCA acompañada de plastia de apoyo periférica. No obstante, no se encuentra un resultado final con rodillas totalmente estables. También son independientes del tratamiento recibido la reincorporación a actividades deportivas previas, así como la aparición de lesiones estructurales secundarias en la rodilla. Debido a la falta de cumplimentación de las exigencias de evaluación y a la falta de adecuación de las técnicas analizadas, no se puede concluir una guía de recomendación.Introduction. The increase in the sport activities and the traffic accidentability has raised an increase of the injuries of the knee and more precisely of the anterior cruciate ligament. The residual instability, the degenerative changes in the joint and the secondary lesions have been invocated as reasons to justify a surgical approach. But, the incomplete consecution of the aims of this treatment has provoked that the conservative option is still in use. Aims: To analyze the scientific evidence in the bibliography for the treatment of the lesions of the knee ACL, to establish if the aims of the treatment are observed in the conservative and surgical options and to conclude with a recommended guide to face these injuries. Material and methods: It is analized the scientific evidence in the reviewed literature in this topic. It is projected a metanalysis with the integrated bibliography for the selected papers. This should assure the criteria of being comparative between the conservative and surgical treatment and should be prospective and randomized, with a minimum follow-up of seven years and taking into account an analysis of the results with objective criteria, as well as an evaluation of the subjective satisfaction of the patient. Results: No papers have been found that properly fit for the exigencies of the design. Two sequential papers have been selected with a shorter follow-up and with a comparison between three different treatments, none of them being a complete conservative treatment. The proposed surgical technique, the suture of the disrupted ACL, is not any more among the preferred by the surgeons. Conclusions: The option with less residual instability is the direct suture with a peripheral plastia. But, they do not provide an absolute stable knee. The reincorporations to the sport activities, as well as the secondary structural lesions are independent to the treatment. Because of the lack of complementation of the exigencies of the evaluation and the lack of adequacy of the proposed surgical techniques, it is not possible to recommend a practical guide

Epidemiología de las fracturas de perfil osteoporótico

Las fracturas osteoporóticas de cadera van acompañadas de una morbimortalidad altas. Entre los factores de riesgo de padecer una fractura de este tipo se encuentra el haber sufrido otra fractura de este tipo con anterioridad. Objetivo: conocer las características epidemiológicas de los pacientes con fractura de perfil osteoporótico en el área sanitaria dependiente del Hospital "Virgen de la Victoria" de Málaga. Pacientes y métodos: se incluyen a las mujeres que han sufrido una fractura de tipo osteoporótico en cualquier localización anatómica. Estudio de tipo indagatorio estadístico. Se utiliza a base de datos del programa GIOS (MSD®), en la que se recogen características antropomórficas de las pacientes, así como los hábitos, factores de riesgo y toma de medicación previa

Search for charginos, neutralinos, and gravitinos at LEP

The hep-ex data base was decided not to be an appropriate place to make DELPHI notes public. Sorry for the inconvenience.Comment: the paper should not have been made publi

Meshfree numerical schemes applied to seepage problems through earth dams

Modelling seepage along with the mechanical responses of deformable Earth Dams under transient conditions is a challenging task, since both coupling between different phases, and computation of free-surface variables are involved. In the present work, we take on the meshfree numerical schemes to establish a framework for solving coupled, transient problems for unconfined seepage through Earth Dams. The equations of Biot are formulated in displacement (or u − w formulation) assuming an elastic solid skeleton. Shape functions based on the principle of Maximum Entropy are implemented for the meshfree framework. The free surface location and its evolution in time, is obtained by interpolation of pore water pressures through the domain. Applications to benchmark problems are compared with available results in the literature. The preliminary simulations for steady flow conditions show promising results

Formulation of exactly balanced solvers for blood flow in elastic vessels and their application to collapsed states

In this work, numerical solvers based on extensions of the Roe and HLL schemes are adapted to deal with test cases involving extreme collapsing conditions in elastic vessels. To achieve this goal, the system is transformed to provide a conservation–law form, allowing to define Rankine–Hugoniot conditions. The approximate solvers allow to describe the inner states of the solution. Therefore, source term fixes can be used to prevent unphysical values of vessel area and, at the same time, the eigenvalues of the system control stability. Numerical solvers of different order are tested using a wide variety of Riemann problems, including extreme vessel collapse and blockage. In all cases, the robustness of the approximate solvers presented here is checked using first and third order methods in time and space, using the WENO reconstruction scheme in combination with the TVDRK3 method

Dynamic consolidation problems in saturated soils solved through u-w formulation in a LME meshfree framework

A meshfree numerical model, based on the principle of Local Maximum Entropy (LME), including a B-bar algorithm to avoid instabilities, is applied to solve axisymmetric consolidation problems in elastic saturated soils. This numerical scheme has been previously validated for purely elastic problems without water (mono phase), as well as for steady seepage in elastic porous media. Hereinafter, an implementation of the novel numerical method in the axisymmetric configuration is proposed, and the model is validated for well known theoretical problems of consolidation in saturated soils, under both static and dynamic conditions with available analytical solutions. The solutions obtained with the new methodology are compared with a finite element commercial software for a set of examples. After validated, solutions for dynamic radial consolidation and sinks, which have not been found elsewhere in the literature, are presented as a novelty. This new numerical approach is demonstrated to be feasible for this kind of problems in porous media, particularly for high frequency, dynamic problems, for which very few results have been found in the literature in spite of their high practical importance

Displasia glenoidea bilateral dolorosa asociada a inestabilidad

La hipoplasia glenoidea es una alteración relativamente infrecuente, de la que han sido descritos menos de 100 casos. Se comunica un caso de una enferma de 17 años de edad con clínica de dolor e inestabilidad en ambos hombros y hallazgo de displasia bilateral de cavidad glenoidea. Se realizó tratamiento conservador mediante pauta de refuerzo muscular con bandas elásticas de resistencia creciente con un resultado excelente calificado según puntuación de tabla de Rowe y cols. Desapareciendo la sensación de inestabilidad y habiendo cedido la clínica álgica.The glenoid hypoplasia is an uncommon condition. Less than 100 cases have been reported. We present the case of a 17 year old girl complaining of pain and instability in both shoulders and radiological findings of bilateral dysplasia of the glenoid. A non-operative treatment has been followed with an exercise program to strengthen the shoulder. This has been achieved with a progressive resistance rubber bands program. The final result has been excellent according to the appraisal table by Rowe et al., disappearing the instability sensation as well as the pain

Development of POD-based Reduced Order Models applied to shallow water equations using augmented Riemann solvers

Reduced-order models (ROMs) based on the proper orthogonal decomposition have been proposed to reduce the computational resources required by the full-order models (FOMs) to approximate partial differential equations. In this paper a Roe-based ROM is developed to solve the shallow water equations in presence of source terms more efficiently than the Roe-based FOM. The well-balanced property and other numerical corrections such as the entropy fix and the wet–dry treatment are taken into account using augmented Riemann solvers to build the Roe-based FOM. In addition to this, a time averaging approach is necessary to develop the Roe-based ROM. This approach is validated by solving some cases and the computed solutions are compared with those ones of Lax–Friedrichs-based ROMs. It is also studied whether the ROM preserves or not the well-balancing, the entropy fix and the wet–dry treatment