SELNET clinical practice guidelines for bone sarcoma

Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity and low frequency. This approach leads to an improvement in patient's outcome, as demonstrated in several studies. The Sarcoma European Latin-American Network (SELNET), aims to improve clinical outcome in sarcoma care, with a special focus in Latin-American countries. These Clinical Practice Guidelines (CPG) have been developed and agreed by a multidisciplinary expert group (including medical and radiation oncologist, surgical oncologist, orthopaedic surgeons, radiologist, pathologist, molecular biologist and representatives of patients advocacy groups) of the SELNET consortium, and are conceived to provide the standard approach to diagnosis, treatment and follow-up of bone sarcoma patients in the Latin-American context

Components of the leaf area index of marandu palisadegrass swards subjected to strategies of intermittent stocking Componentes do índice de área foliar de pastos de capim-marandu submetidos a estratégias de lotação intermitente

Leaf area index is the main sward characteristic related to the processes of light interception and competition in plant communities. The objective of this experiment was to quantify and evaluate the composition of the leaf area on tillers of marandu palisadegrass (Brachiaria brizantha cv. Marandu) subjected to strategies of intermittent stocking. The experiment was carried out in Piracicaba, state of São Paulo, Brazil, from October/2004 to December/2005. Swards were grazed at 95 and 100% canopy light interception (LI) to post-grazing heights of 10 and 15 cm, following a 2 ' 2 factorial arrangement with four replications in a randomised complete block design. Estimates were made of sward leaf area index, site filling, specific leaf area and the dimensionless ratio between tiller leaf area and volume (R), as well as the relative contribution of basal and aerial tillers to these variables. In early spring, values of leaf area index and specific leaf area were low when compared to the other seasons, and swards grazed at 95% LI presented higher site filling and specific leaf area than those grazed at 100% LI. This resulted in higher tillering activity and increase in leaf area index in late spring, indicating quick recovery and early return of swards grazed at 95% LI to growing conditions. Aerial tillers corresponded to an important morphological adaptation of marandu palisadegrass to increase its competitive ability. Treatment 100/10 resulted in the highest and 95/15 in the lowest R values throughout the experiment, suggesting an allometric pattern of growth of tillers during regrowth in order to compensate low tiller population and optimise the leaf area index. Grazing management practices can benefit from this knowledge by promoting ideal sward conditions to maximise and accelerate growth.<br>O índice de área foliar é a principal característica do dossel relacionada com os processos de interceptação e competição por luz em comunidades de plantas. O objetivo deste experimento foi quantificar e avaliar a composição da área foliar dos perfilhos em pastos de capim-marandu (Brachiaria brizantha cv. Marandu) submetidos a estratégias de lotação intermitente. O experimento foi conduzido em Piracicaba, SP, Brasil, de outubro/2004 a dezembro/2005. Os pastejos foram realizados quando o dossel atingia 95 ou 100% de interceptação luminosa (IL) até as alturas pós-pastejo de 10 e 15 cm, seguindo um arranjo fatorial 2 ' 2 com 4 repetições e um delineamento de blocos completos casualizados. Foram estimados o índice de área foliar, site filling, área foliar específica e a relação adimensional entre área foliar e volume dos perfilhos (R), além da participação relativa de perfilhos basais e aéreos na composição dessas variáveis. No início de primavera os valores de índice de área foliar e área foliar específica foram baixos, e pastos manejados com 95% de IL apresentaram maior site filling e área foliar específica que pastos manejados com 100% de IL. Isso resultou em maior perfilhamento e aumento no índice de área foliar no final de primavera, indicando rápida recuperação e retorno precoce dos pastos manejados com 95% de IL a condições de crescimento. Os perfilhos aéreos corresponderam a uma importante adaptação morfológica do capim-marandu para aumentar sua habilidade competitiva. O tratamento 100/10 resultou nos maiores e o 95/15 nos menores valores de R, sugerindo um padrão alométrico de crescimento dos perfilhos durante a rebrotação para compensar baixa densidade populacional e otimizar o índice de área foliar. Práticas de manejo do pastejo podem se beneficiar desse conhecimento propiciando condições ideais de dossel para maximização e aceleração do crescimento