Gravitational Geometric Phase in the Presence of Torsion

We investigate the relativistic and non-relativistic quantum dynamics of a neutral spin-1/2 particle submitted an external electromagnetic field in the presence of a cosmic dislocation. We analyze the explicit contribution of the torsion in the geometric phase acquired in the dynamic of this neutral spinorial particle. We discuss the influence of the torsion in the relativistic geometric phase. Using the Foldy-Wouthuysen approximation, the non-relativistic quantum dynamics are studied and the influence of the torsion in the Aharonov-Casher and He-McKellar-Wilkens effects are discussed.Comment: 14 pages, no figur

Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans

From 2nd Latin American Congress of Clinical and Laboratorial Toxicology Porto Alegre, Brazil. 3-6 June 2018Background: Chagas disease (CD) is a tropical parasitic disease. Although the number of people infected is very high, the only drugs available to treat CD, nifurtimox (Nfx) and benznidazole, are highly toxic, particularly in the chronic stage of the disease. Coumarins are a large class of compounds that display a wide range of interesting biological properties, such as antiparasitic. Hence, the aim of this work is to find a good antitrypanosomal drug with less toxicity. The use of simple organism models has become increasingly attractive for planning and simplifying efficient drug discovery. Within these models, Caenorhabditis elegans has emerged as a convenient and versatile tool with significant advantages for the toxicological potential identification for new compounds. Methods: Trypanocidal activity: Forty-two 4-methylamino-coumarins were assayed against the epimastigote form of Trypanosoma cruzi (Tulahuen 2 strain) by inhibitory concentration 50% (IC50). Toxicity assays: Lethal dose 50% (LD50) and Body Area were determined by Caenorhabditis elegans N2 strain (wild type) after acute exposure. Structure-activity relationship: A classificatory model was built using 3D descriptors. Results: Two of these coumarins demonstrated near equipotency to Nifurtimox (IC50 = 5.0 ± 1 μM), with values of: 11 h (LaSOM 266), (IC50 = 6.4 ± 1 μM) and 11 g (LaSOM 231), (IC50 = 8.2 ± 2.3 μM). In C. elegans it was possible to observe that Nfx showed greater toxicity in both the LD50 assay and the evaluation of the development of worms. It is possible to observe that the efficacy between Nfx and the synthesized compounds (11 h and 11 g) are similar. On the other hand, the toxicity of Nfx is approximately three times higher than that of the compounds. Results from the QSAR-3D study indicate that the volume and hydrophobicity of the substituents have a significant impact on the trypanocidal activities for derivatives that cause more than 50% of inhibition. These results show that the C. elegans model is efficient for screening potentially toxic compounds. Conclusion: Two coumarins (11 h and 11 g) showed activity against T. cruzi epimastigote similar to Nifurtimox, however with lower toxicity in both LD50 and development of C. elegans assays. These two compounds may be a feasible starting point for the development of new trypanocidal drugs

ADVANCES IN THE PROPAGATION OF RAMBUTAN TREE

ABSTRACT The reality of Brazilian fruit farming is demonstrating increasing demand for sustainable information about native and exotic fruit, which can diversify and elevate the efficiency of fruit exploitation. Research on propagation of fruits tree is very important so that it can provide a protocol for suitable multiplication of this fruitful. Due to the great genetic diversity of rambutan plants, it is recommended the use of vegetative propagated plants. This research aimed to evaluate the propagation of rambutan by cuttings, layering and grafting, as well as seed germination and viability without storage. The results of this research indicate that this species can be successfully propagated by layering, grafting and seeds. We also observed that the germination percentage of seeds kept inside the fruits for six days were not influenced by the different substrates used in this experiment

Superação de dormência de sementes de Piptadenia moniliformis Benth

O angico-de-bezerro (Piptadenia moniliformis Benth.) é uma espécie arbórea melífera, de crescimento rápido, característica da caatinga do nordeste brasileiro, onde é muito abundante e com dispersão contígua e irregular. Seus ramos finos, junto com as folhas, servem como alimento para animais. Como suas sementes apresentam dormência por impermeabilidade do tegumento à água, objetivou-se neste trabalho avaliar a eficiência de tratamentos pré-germinativos para superar a dormência de suas sementes visando maximizar e uniformizar o processo de germinação. Foram estudados 28 tratamentos pré-germinativos: imersão em água a 70, 80, 90 ºC e fervente por 1, 2, 3, 4 e 5 minutos e imersão em ácido sulfúrico concentrado por 1, 5, 10, 15, 20, 25 e 30 minutos, além da testemunha. A semeadura foi realizada sobre papel em temperatura alternada de 20-30 ºC, utilizando-se quatro repetições de 25 sementes. Foram avaliadas as porcentagens de germinação das sementes considerando a protrusão da raiz primária, de plântulas normais e de sementes duras e o índice de velocidade de germinação. O delineamento experimental utilizado foi o inteiramente casualizado e as médias comparadas pelo teste de Scott-Knott a 5% de probabilidade. Os tratamentos de imersão em água, independentemente da temperatura e do período de imersão, aumentaram a porcentagem de germinação das sementes, comparativamente ao tratamento controle, mas foram menos eficientes que os tratamentos em ácido sulfúrico nos maiores períodos de imersão. Desta forma, a imersão por 20, 25 e 30 minutos em ácido sulfúrico é recomendada para a superação da dormência de sementes de Piptadenia moniliformis Benth.The rapidly-growing honey-tree species Piptadenia moniliformis Benth. is typical of the Brazilian northeastern caatinga (scrubland), where it is found abundantly, contiguously and irregularly dispersed. The thin branches and leaves of this tree are used as animal fodder. The seeds of P. moniliformis present dormancy due to the seed-coat being impermeable to water. We evaluated the efficiency of pre-germinating treatments to overcome P. moniliformis dormancy and maximize and uniformize germination. A total of 28 pre-germination treatments were investigated: immersion in water at 70 ºC, 80 ºC or 90 ºC; boiling for 1, 2, 3, 4 or 5 minutes; immersion in concentrated sulfuric acid for 1, 5, 10, 15, 20, 25 or 30 minutes; and no treatment (control). After treatment, seeds were sown on paper and incubated at alternating temperatures of 20 ºC-30 ºC. Four replicates of 25 seeds were used for each treatment. The factors evaluated were: percentage of seeds with primary root protrusion; percentage of normal seedlings; percentage of hard seeds and the speed of germination index. The experimental design was completely randomized and the means were compared using the Scott-Knott test at a probability of 5%. Immersion in water, independent of the temperature and immersion period, increased germination as compared to control seeds but was less efficient than the longer periods of immersion in sulfuric acid. Thus, the immersion in sulfuric acid for 20, 25 and 30 minutes is recommended for the overcoming of Piptadenia moniliformis Benth. seeds.Unesp/JaboticabalUniversidade Estadual Paulista Departamento de Produção VegetalUniversidade Estadual Paulista Departamento de Biologia Aplicada a AgropecuáriaUnesp/JaboticabalUniversidade Estadual Paulista Departamento de Produção VegetalUniversidade Estadual Paulista Departamento de Biologia Aplicada a Agropecuári