Gradual crossover in molecular organization of stable liquid H2O at moderately high pressure and temperature

Using the literature raw data of the speed of sound and the specific volume, the isothermal compressibility, κT, a second derivative thermodynamic quantity of G, was evaluated for liquid H2O in the pressure range up to 350 MPa and the temperature to 50 ºC. We then obtained its pressure derivative, dκT/dp, a third derivative numerically without using a fitting function to the κT data. On taking yet another p-derivative at a fixed T graphically without resorting to any fitting function, the resulting d2κT/dp2, a fourth derivative, showed a weak but clear step anomaly, with the onset of the step named point X and its end point Y. In analogy with another third and fourth derivative pair in binary aqueous solutions of glycerol, dαp/dxGly and d2αp/dxGly2, at 0.1 MPa (αp is the thermal expansivity and xGly the mole fraction of solute glycerol) in our recent publication [J. Solution Chem. 43, 663-674 (2014); DOI:10.1007/s10953-013-0122-7], we argue that there is a gradual crossover in the molecular organization of pure H2O from a low to a high p-regions starting at point X and ending at Y at a fixed T. The crossover takes place gradually spanning for about 100 MPa at a fixed temperature. The extrapolated temperature to zero p seems to be about 70 – 80 °C for points X and 90 – 110 °C for Y. Furthermore, the mid-points of X and Y seem to extrapolate to the triple point of liquid, ice Ih and ice III. Recalling that the zero xGly extrapolation of point X and Y for binary aqueous glycerol at 0.1 MPa gives about the same T values respectively, we suggest that at zero pressure the region below about 70 °C the hydrogen bond network is bond-percolated, while above about 90 ºC there is no hydrogen bond network. Implication of these findings is discussed

Thermodynamics of Calcium Ferrite Slags at 1200 and 1300℃

Oxygen isobars and liquidus isotherms of the system CaO-FeO-Fe_2O_3 at 1200 and 1300℃ were determined by quenching samples equilibrated with CO_2-CO mixtures. The iron liquidus and the melt coexisting with two solids were carefully examined in terms of their composition as well as the equilibrium oxygen partial pressures, po_2. At 1200℃, po_2 was 10^ atm when the slag coexisted with magnetite and dicalcium ferrite. At 1300℃, the melt region extends to the CaO-Fe_2O_3 join, where po_2 was 10^ atm (air) or higher. Within the range of po_2 from one order above that at iron saturation to 10^ atm, the slag composition, po_2, and the temperature T are related by the equation : log(Fe^/Fe^) ≈ 0.170logpo_2 + 0.018(wt % CaO) + 5500/T - 2.52. Activities of CaO(s), FeO(l), and Fe_3O_4(s) in the slag were calculated from the po_2 data by combining the available thermal data and/or by Gibbs-Duhem equation

Changes in Membrane Potentials and Mechanical Responses of Guinea Pig Atria During Anaphylaxis in Vitro

The anaphylactic reaction in the isolated atria of sensitized guinea pigs is principally to cause acceleration of cardiac activities as already reported. The present attempt was made to observe changes in transmembrane action potentials (AP) and mechanical responses of the atria during the anaphylaxis. Four types of changes in AP were found in spontaneously beating atria that is prolongation of AP at all points of the repolarization, prolongation of the duration with proceeding of repolarization, shortening of the duration at first half, and no change at all in AP pattern. However the change in electrically driven left atria was only a parallel prolongation of the duration to the control in repolarization phase. On the other hand, an increase in the rate shortend the duration of AP in the normal preparation electrically driven. The essential change of the contour of AP in the anaphylactic reaction is the prolongation of AP in repolarization phase. Histamine induced a similar reaction in electrical and mechanical responses to the anaphylactic reaction

Thalidomide Prevents the Progression of Peritoneal Fibrosis in Mice

Thalidomide is clinically recognized as a therapeutic agent for multiple myeloma and has been known to exert anti-angiogenic actions. Recent studies have suggested the involvement of angiogenesis in the progression of peritoneal fibrosis. The present study investigated the effects of thalidomide on the development of peritoneal fibrosis induced by injection of chlorhexidine gluconate (CG) into the mouse peritoneal cavity every other day for 3 weeks. Thalidomide was given orally every day. Peritoneal tissues were dissected out 21 days after CG injection. Expression of CD31 (as a marker of endothelial cells), proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), α-smooth muscle actin (as a marker of myofibroblasts), type III collagen and transforming growth factor (TGF)-β was examined using immunohistochemistry. CG group showed thickening of the submesothelial zone and increased numbers of vessels and myofibroblasts. Large numbers of VEGF-, PCNA-, and TGF-β-positive cells were observed in the submesothelial area. Thalidomide treatment significantly ameliorated submesothelial thickening and angiogenesis, and decreased numbers of PCNA- and VEGF-expressing cells, myofibroblasts, and TGF-β-positive cells. Moreover, thalidomide attenuated peritoneal permeability for creatinine, compared to the CG group. Our results indicate the potential utility of thalidomide for preventing peritoneal fibrosis

Discovery and informing research participants of incidental findings detected in brain magnetic resonance imaging studies : Review and multi‐institutional study

Background: Brain imaging studies using magnetic resonance imaging (MRI ) sometimes reveal incidental findings (IFs) that might be relevant to some of the health issues in research participants. Although professional communities have discussed how to manage these IFs, there is no global consensus on the concrete handling procedures including how to inform participants of IFs. Methods: First, this study reviewed previous studies for the number of IFs discovered in brain imaging studies using MEDLINE. Second, a multi‐institutional study determined the number of IF discoveries and evaluated the method of informing participants at multiple institutions, which participated in a national brain science project in Japan. Results: Both the review and multi‐institutional study showed that IFs with a high urgency level were discovered in 0–2.0% of participants, including healthy volunteers, and that the rate of IF discovery in general was higher in studies conducted in elderly population. Moreover, multi‐institutional study suggested the criteria used to judge whether or not to inform participants of IFs may differ by institution. Conclusions: Our results suggest that in order to ensure informing the participants of high urgency IFs, physicians who are capable of interpreting brain images clinically should review all brain images, and the establishment of a support system is required for brain imaging studies at nonmedical institutions. Since the method of informing participants of IFs might affect their understanding and acceptance of IFs, which are related to managing risks of false “clean bill of health” or psychological impacts of informing IFs, further research focusing on communication of IFs is needed

Narratives on the Current Medical Situation in Japan According to Highly Specialized Foreign Professionals

In order to understand the difficulties faced by highly skilled foreign professionals when dealing with the Japanese healthcare system and to identify the support they require therein, university health center staff members of the Okinawa Institute of Science and Technology Graduate University conducted semi-structured interviews with faculty, staff, and students from the Institute. Data from the interviews were analyzed by subject matter analysis using a narrative-oriented approach. In total, 13 participants were interviewed, and five themes and 15 subthemes were generated from the 40 codes extracted. Although participants considered themselves to be accepting of other cultures and made little mention of the need for cultural and religious considerations that previous studies have identified as important, they reported that their experiences receiving healthcare in Japan were fraught with many difficulties. They felt that the capacity to communicate in Japanese was a prerequisite for receiving appropriate healthcare and that hospitals should assume the responsibility of providing language support. While they reported satisfaction with the easy and inexpensive access to advanced medical equipment and specialists in Japan, they also noted challenges in selecting medical institutions and departments, the flow and procedures in the hospital, and building open and direct relationships with doctors. In addition, based on the present study, people with chronic illnesses felt isolated from the community, worried about a lack of privacy, and wanted a primary care physician they could trust. In order to provide appropriate healthcare to foreigners, we require an accurate understanding of their needs, how to address these comprehensively and in a multifaceted manner, and how the communication responsibilities should be shared among the involved parties (i.e., foreign care recipients and Japanese medical professionals)

An Exploratory Quantitative Study of Factors Associated with Dissatisfaction with Japanese Healthcare among Highly Skilled Foreign Professionals Living in Japan

Background: To identify factors necessary for the proper inclusion of foreigners in Japanese healthcare, we conducted a survey to determine whether foreign residents, even those with high socioeconomic status, referred to as “Highly Skilled Foreign Professionals”, experience difficulties when visiting medical institutions in Japan, using satisfaction level as an indicator. Method: A five-point Likert-scale, anonymous, online questionnaire was administered to faculty and doctoral students enrolled at the Okinawa Institute of Science and Technology Graduate University (OIST). The respondents’ demographics and their opinions on what they found difficult or important during medical examinations, their impression of Japanese medical personnel, their requirements for language support and interpretation, and their opinions about local healthcare delivery systems were collected. The questionnaires were distributed and collected using Microsoft Forms. Results: Responses were obtained from 90 respondents (response rate: 20.7%). The percentage of respondents who were dissatisfied (bottom two of five Likert scales) with medical care in Japan was 23.4%. In univariate logistic regression analysis, 11 of 35 questions were significantly correlated with dissatisfaction with medical care (p < 0.1). Duration of stay, presence of family members living with the patient, satisfaction with life, and perceived usefulness of language support were negatively correlated with dissatisfaction with medical care, while communication problems with medical personnel, need for medical personnel to respect patients’ culture, religion, and privacy, and difficulty in getting to medical facilities were positively correlated with dissatisfaction with medical care. No significant correlations were found with age, gender, or Japanese language level. Multiple logistic regression analysis showed that the presence of family members living with the subject (AOR = 0.092, p = 0.010), the desire for multilingual documentation (AOR = 0.177, p = 0.046), the physician’s concern for the patient’s culture and religion (AOR = 8.347, p = 0.029), and difficulty in communication with healthcare providers (AOR = 6.54, p = 0.036) were significantly correlated with overall dissatisfaction with medical care. Discussion: On average, the targeted Highly Skilled Foreign Professionals did not have strong levels of dissatisfaction with Japanese healthcare, but when they did have dissatisfaction, it was related to language barriers, lack of cultural and religious considerations, and difficulty in communication with healthcare providers. We believe that the results indicate the focus points of support necessary for the inclusion of foreigners. We also believe that the finding that family cohabitation is associated with satisfaction with medical care is a useful insight into effective reciprocal support on the part of patients

Quantum fluctuation effects on hyperfragment formation from Xi^- absorption at rest on 12C

Formation mechanisms of single, twin, and double hypernuclei from Xi^- absorption at rest on 12C are investigated with an refined microscopic transport model, that incorporates the recently developed Quantal Langevin treatment into Antisymmetrized Molecular Dynamics. The quantum fluctuations suppress the formation probability of double hyperfragments to around 10%, which is comparable to the experimental data, and the dynamical formation of twin hyperfragment can be described qualitatively.Comment: 30 pages, PTP-TeX with epsf, and embedded 8 PS figures, Largely revise

When to help juveniles, adults, or both: analyzing the evolutionary models of stage-structured mutualism

Mutualism is common in nature and is crucial for population dynamics, community structure, and ecosystem functioning. Studies have recently pointed out that life-history stage structure (e.g., juveniles and adults) is a key factor to better understand the ecological consequences of mutualism (termed stage-structured mutualism). Despite the potential importance, little is known about what kinds of stage-structured mutualism can evolve and when it is likely to occur. Here, we theoretically investigated how a mutualistic partner species should allocate efforts of mutualistic associations for different life-history stages of its host species to maximize its fitness. We assessed the partner’s optimal strategy by using a one host–one partner model with the host’s juvenile-adult stage structure. The results showed that different forms of stage-structured mutualism can evolve, such as juvenile-specialized association, adult-specialized association, and inter-stage partner sharing (i.e., the partner associates with both the juvenile and adult stages of the host) depending on the shape of association trade-off, i.e., how much association with one stage is weakened when the partner strengthens its association with the other stage. In general, stage-specialized association (either juvenile-specialized or adult-specialized association) tends to evolve when being associated with that stage is relatively beneficial. Meanwhile, when the association trade-off is weak, inter-stage partner sharing can occur if the mutualistic benefits of juvenile-specific and adult-specific associations are sufficiently large. We also found that when the association trade-off is strong, alternative stable states occur in which either juvenile-specialized or adult-specialized associations evolve depending on the initial trait value. These results suggest that pairwise interspecific mutualism is more complicated than previously thought, implying that we may under-or overestimate the strength of mutualistic interactions when looking at only certain life-history stages. This study provides a conceptual basis for better understanding the mechanisms underlying ontogenetic shifts of mutualistic partners and more complex mutualistic networks mediated by the life-history stages of organisms and their stage-structured interactions