181 research outputs found

    Quality management manual for the production of gari

    Get PDF

    Blockade of SARS-CoV-2 Spike Protein-Mediated Cell–Cell Fusion Using COVID-19 Convalescent Plasma

    Get PDF
    The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cell–cell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. Importantly, we find that COVID-19 convalescent plasma with high titers of IgG neutralizing antibodies can block cell–cell fusion and virus entry by interfering with the SARS-CoV-2-S/ACE2 or SARS-CoV-S/ACE2 interactions. These findings suggest that COVID-19 convalescent plasma may not only inhibit SARS-CoV-2-S but also cross-neutralize SARS-CoV-S-mediated membrane fusion and virus entry, supporting its potential as a preventive and/or therapeutic agent against SARS-CoV-2 as well as other SARS-CoV infections

    Overproduction of cosmic superstrings

    Full text link
    We show that the naive application of the Kibble mechanism seriously underestimates the initial density of cosmic superstrings that can be formed during the annihilation of D-branes in the early universe, as in models of brane-antibrane inflation. We study the formation of defects in effective field theories of the string theory tachyon both analytically, by solving the equation of motion of the tachyon field near the core of the defect, and numerically, by evolving the tachyon field on a lattice. We find that defects generically form with correlation lengths of order M_s^{-1} rather than H^{-1}. Hence, defects localized in extra dimensions may be formed at the end of inflation. This implies that brane-antibrane inflation models where inflation is driven by branes which wrap the compact manifold may have problems with overclosure by cosmological relics, such as domain walls and monopoles.Comment: 31 pages, 16 figures, JHEP style; References added; Improved discussion of initial condition

    Identification and mitigation of a vibrational telescope systematic with application to spitzer

    Get PDF
    We observed Proxima Centauri with the Spitzer Space Telescope Infrared Array Camera five times in 2016 and 2017 to search for transits of Proxima Centauri b. Following standard analysis procedures, we found three asymmetric, transit-like events that are now understood to be vibrational systematics. This systematic is correlated with the width of the point-response function (PRF), which we measure with rotated and nonrotated-Gaussian fits with respect to the detector array. We show that the systematic can be removed with a novel application of an adaptive elliptical-aperture photometry technique, and compare the performance of this technique with fixed and variable circular-aperture photometry, using both BiLinearly Interpolated Subpixel Sensitivity (BLISS) maps and nonbinned Pixel-Level Decorrelation (PLD). With BLISS maps, elliptical photometry results in a lower standard deviation of normalized residuals, and reduced or similar correlated noise when compared to circular apertures. PLD prefers variable, circular apertures, but generally results in more correlated noise than BLISS. This vibrational effect is likely present in other telescopes and Spitzer observations, where correction could improve results. Our elliptical apertures can be applied to any photometry observations, and may be even more effective when applied to more circular PRFs than Spitzer's.The authors acknowledge support from the following: CATA-Basal/Chile PB06 Conicyt and Fondecyt/Chile project #1161218 (J.S.J.). Spanish MINECO programs AYA2016-79245-C03-03-P, ESP2017-87676-C05-02-R (E.R.), ESP2016-80435-C2-2-R (E.P.) and through the “Centre of Excellence Severo Ochoa” award SEV-2017-0709 (P.J.A.,C.R.-L., E.R.). STFC Consolidated Grant ST/P000592/1 (G.A.E.). NASA Planetary Atmospheres Program grant NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G (R.C., J.H., K.M., M.H.). Spanish Ministry of Science, Innovation and Universities and the Fondo Europeo de Desarrollo Regional (FEDER) through grant ESP2016-80435-C2-1-R and PGC2018-098153-B-C33 (I.R.)

    Uplifting and Inflation with D3 Branes

    Get PDF
    Back-reaction effects can modify the dynamics of mobile D3 branes moving within type IIB vacua, in a way which has recently become calculable. We identify some of the ways these effects can alter inflationary scenarios, with the following three results: (1) By examining how the forces on the brane due to moduli-stabilizing interactions modify the angular motion of D3 branes moving in Klebanov-Strassler type throats, we show how previous slow-roll analyses can remain unchanged for some brane trajectories, while being modified for other trajectories. These forces cause the D3 brane to sink to the bottom of the throat except in a narrow region close to the D7 brane, and do not ameliorate the \eta-problem of slow roll inflation in these throats; (2) We argue that a recently-proposed back-reaction on the dilaton field can be used to provide an alternative way of uplifting these compactifications to Minkowski or De Sitter vacua, without the need for a supersymmetry-breaking anti-D3 brane; and (3) by including also the D-term forces which arise when supersymmetry-breaking fluxes are included on D7 branes we identify the 4D supergravity interactions which capture the dynamics of D3 motion in D3/D7 inflationary scenarios. The form of these potentials sheds some light on recent discussions of how symmetries constrain D term interactions in the low-energy theory.Comment: JHEP.cls, 35 pages, 3 .eps figure

    Inflating in a Better Racetrack

    Full text link
    We present a new version of our racetrack inflation scenario which, unlike our original proposal, is based on an explicit compactification of type IIB string theory: the Calabi-Yau manifold P^4_[1,1,1,6,9]. The axion-dilaton and all complex structure moduli are stabilized by fluxes. The remaining 2 Kahler moduli are stabilized by a nonperturbative superpotential, which has been explicitly computed. For this model we identify situations for which a linear combination of the axionic parts of the two Kahler moduli acts as an inflaton. As in our previous scenario, inflation begins at a saddle point of the scalar potential and proceeds as an eternal topological inflation. For a certain range of inflationary parameters, we obtain the COBE-normalized spectrum of metric perturbations and an inflationary scale of M = 3 x 10^{14} GeV. We discuss possible changes of parameters of our model and argue that anthropic considerations favor those parameters that lead to a nearly flat spectrum of inflationary perturbations, which in our case is characterized by the spectral index n_s = 0.95.Comment: 20 pages, 7 figures. Brief discussion on the non-gaussianity of this model, one more figure of the field trajectories added as well as other minor changes to the tex
    • 

    corecore