181 research outputs found
'Little Story Books' and 'Small Pamphlets' in Edinburgh, 1680-1760:the Making of the Scottish Chapbook
Blockade of SARS-CoV-2 Spike Protein-Mediated CellâCell Fusion Using COVID-19 Convalescent Plasma
The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cellâcell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. Importantly, we find that COVID-19 convalescent plasma with high titers of IgG neutralizing antibodies can block cellâcell fusion and virus entry by interfering with the SARS-CoV-2-S/ACE2 or SARS-CoV-S/ACE2 interactions. These findings suggest that COVID-19 convalescent plasma may not only inhibit SARS-CoV-2-S but also cross-neutralize SARS-CoV-S-mediated membrane fusion and virus entry, supporting its potential as a preventive and/or therapeutic agent against SARS-CoV-2 as well as other SARS-CoV infections
Overproduction of cosmic superstrings
We show that the naive application of the Kibble mechanism seriously
underestimates the initial density of cosmic superstrings that can be formed
during the annihilation of D-branes in the early universe, as in models of
brane-antibrane inflation. We study the formation of defects in effective field
theories of the string theory tachyon both analytically, by solving the
equation of motion of the tachyon field near the core of the defect, and
numerically, by evolving the tachyon field on a lattice. We find that defects
generically form with correlation lengths of order M_s^{-1} rather than H^{-1}.
Hence, defects localized in extra dimensions may be formed at the end of
inflation. This implies that brane-antibrane inflation models where inflation
is driven by branes which wrap the compact manifold may have problems with
overclosure by cosmological relics, such as domain walls and monopoles.Comment: 31 pages, 16 figures, JHEP style; References added; Improved
discussion of initial condition
Identification and mitigation of a vibrational telescope systematic with application to spitzer
We observed Proxima Centauri with the Spitzer Space Telescope Infrared Array Camera five times in 2016 and 2017 to search for transits of Proxima Centauri b. Following standard analysis procedures, we found three asymmetric, transit-like events that are now understood to be vibrational systematics. This systematic is correlated with the width of the point-response function (PRF), which we measure with rotated and nonrotated-Gaussian fits with respect to the detector array. We show that the systematic can be removed with a novel application of an adaptive elliptical-aperture photometry technique, and compare the performance of this technique with fixed and variable circular-aperture photometry, using both BiLinearly Interpolated Subpixel Sensitivity (BLISS) maps and nonbinned Pixel-Level Decorrelation (PLD). With BLISS maps, elliptical photometry results in a lower standard deviation of normalized residuals, and reduced or similar correlated noise when compared to circular apertures. PLD prefers variable, circular apertures, but generally results in more correlated noise than BLISS. This vibrational effect is likely present in other telescopes and Spitzer observations, where correction could improve results. Our elliptical apertures can be applied to any photometry observations, and may be even more effective when applied to more circular PRFs than Spitzer's.The authors acknowledge support from the following: CATA-Basal/Chile PB06 Conicyt and Fondecyt/Chile project #1161218 (J.S.J.). Spanish MINECO programs AYA2016-79245-C03-03-P, ESP2017-87676-C05-02-R (E.R.), ESP2016-80435-C2-2-R (E.P.) and through the âCentre of Excellence Severo Ochoaâ award SEV-2017-0709 (P.J.A.,C.R.-L., E.R.). STFC Consolidated Grant ST/P000592/1 (G.A.E.). NASA Planetary Atmospheres Program grant
NNX12AI69G and NASA Astrophysics Data Analysis Program grant NNX13AF38G (R.C., J.H., K.M., M.H.). Spanish Ministry of Science, Innovation and Universities and the Fondo
Europeo de Desarrollo Regional (FEDER) through grant ESP2016-80435-C2-1-R and PGC2018-098153-B-C33 (I.R.)
Uplifting and Inflation with D3 Branes
Back-reaction effects can modify the dynamics of mobile D3 branes moving
within type IIB vacua, in a way which has recently become calculable. We
identify some of the ways these effects can alter inflationary scenarios, with
the following three results: (1) By examining how the forces on the brane due
to moduli-stabilizing interactions modify the angular motion of D3 branes
moving in Klebanov-Strassler type throats, we show how previous slow-roll
analyses can remain unchanged for some brane trajectories, while being modified
for other trajectories. These forces cause the D3 brane to sink to the bottom
of the throat except in a narrow region close to the D7 brane, and do not
ameliorate the \eta-problem of slow roll inflation in these throats; (2) We
argue that a recently-proposed back-reaction on the dilaton field can be used
to provide an alternative way of uplifting these compactifications to Minkowski
or De Sitter vacua, without the need for a supersymmetry-breaking anti-D3
brane; and (3) by including also the D-term forces which arise when
supersymmetry-breaking fluxes are included on D7 branes we identify the 4D
supergravity interactions which capture the dynamics of D3 motion in D3/D7
inflationary scenarios. The form of these potentials sheds some light on recent
discussions of how symmetries constrain D term interactions in the low-energy
theory.Comment: JHEP.cls, 35 pages, 3 .eps figure
Inflating in a Better Racetrack
We present a new version of our racetrack inflation scenario which, unlike
our original proposal, is based on an explicit compactification of type IIB
string theory: the Calabi-Yau manifold P^4_[1,1,1,6,9]. The axion-dilaton and
all complex structure moduli are stabilized by fluxes. The remaining 2 Kahler
moduli are stabilized by a nonperturbative superpotential, which has been
explicitly computed. For this model we identify situations for which a linear
combination of the axionic parts of the two Kahler moduli acts as an inflaton.
As in our previous scenario, inflation begins at a saddle point of the scalar
potential and proceeds as an eternal topological inflation. For a certain range
of inflationary parameters, we obtain the COBE-normalized spectrum of metric
perturbations and an inflationary scale of M = 3 x 10^{14} GeV. We discuss
possible changes of parameters of our model and argue that anthropic
considerations favor those parameters that lead to a nearly flat spectrum of
inflationary perturbations, which in our case is characterized by the spectral
index n_s = 0.95.Comment: 20 pages, 7 figures. Brief discussion on the non-gaussianity of this
model, one more figure of the field trajectories added as well as other minor
changes to the tex
Adsorption of Cd, Cu, Ni and Zn in tropical soils under competitive and non-competitive systems
Reclaiming international social work in the context of the global agenda for social work and social development:Some critical reflections
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