Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness

How high Is high enough? Assessing financial risk for vertical farms using imprecise probability

Vertical farming (VF) is a method of indoor agricultural production, involving stacked layers of crops, utilising technologies to increase yields per unit area. However, this emerging sector has struggled with profitability and a high failure rate. Practitioners and academics call for a comprehensive economic analysis of vertical farming, but efforts have been stifled by a lack of valid and available data as existing studies are unable to address risks and uncertainty that may support risk-empowered business planning. An adaptable economic analysis is necessary that considers imprecise variables and risks. The financial risk analysis presented uses with a first-hitting-time model with probability bounds to evaluate quasi-insolvency for two unique vertical farms. The UK farm results show that capital injection, robust data collection, frequent cleaning, efficient distribution and cheaper packaging are pathways to profitability and have a safer risk profile. For the Japanese farm, diversification of revenue streams like tours or education reduce financial risk associated with yield and sales. This is the first instance of applying risk and uncertainty quantification for VF business models and it can support wider agricultural projects. Enabling this complex sector to compute with uncertainty to estimate financials could improve access to funding and help other nascent industries

Auto-segmentation of the brachial plexus assessed with TaCTICS - A software platform for rapid multiple-metric quantitative evaluation of contours

La revue Clio a largement œuvré (voir le n° 15 Chrétiennes) pour contrer l’ignorance réciproque entre l’histoire des femmes et du genre et l’histoire religieuse en France, voie ouverte pour la période contemporaine avec la publication de la thèse de Claude Langlois sur les congrégations de vie active au XIXe siècle. Pourtant la bonne sœur reste une figure mal connue des historiennes des femmes en France. Carmen Mangion commence son livre sur le même constat outre-Manche, qu’elle généralise à ..

Constructing measures for school process variables: the potential of multilevel confirmatory factor analysis

School process variables, Secondary education, Multilevel confirmatory factor analysis, Educational effectiveness research,

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer’s disease (rg=−0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness