174 research outputs found
Molecular Mechanisms of Preeclampsia
Preeclampsia is one of the leading causes of maternal morbidity/mortality. The pathogenesis of preeclampsia is still under investigation. The aim of this paper is to present the molecular mechanisms implicating in the pathway leading to preeclampsia
Maternal Serum Levels of TNF-Alpha and IL-6 Long after Delivery in Preeclamptic and Normotensive Pregnant Women
Aim. To evaluate maternal TNF-alpha and IL-6 plasma levels in normotensive pregnant women, women with preeclampsia, and to examine the temporal changes in their levels from theantepartum to the postpartum period correlated with the regression of preeclampsia. Method. A prospective study was performed in the 2nd Department of Obstetrics and Gynecology, University of Athens. Blood samples were obtained: (1) antepartum at the time of clinical diagnosis of the syndrome, 2. 12-14 weeks postpartum. Results. No statistically significant differences were found in IL-6 levels, whereas a difference was found in TNF-alpha levels between preeclamptic and controls in antepartum period (0.80 pg/ml versus 0.60 pg/ml, P : .04). Long after delivery, TNF-alpha levels were significantly higher in preeclamptic compared to normotensive controls (0.86 pg/ml versus 0.60 pg/ml, P : .004). No difference was observed in TNF-alpha before and after delivery in both groups. No difference was noticed in IL-6 levels in women of normotensive group long after delivery compared to that before delivery. Long after delivery IL-6 levels were statistically significant higher in preeclamptic women compared to normal controls (3.53 ± 0.52 pg/ml versus 1.69 ± 0.48 pg/ml, P : .02). Conclusion. Preeclamptic women remain under a status of increased inflammatory stress up to 12-14 weeks postpartum despite the fact that all the other signs of preeclampsia are resolved
CONTRIBUTION OF EMPIRICAL METHODS AND SATELLITE DATA USE FOR ESTIMATING DAILY REFERENCE EVAPOTRANSPIRATION
Στην παρούσα εργασία χρησιμοποιούνται επίγεια και δορυφορικά μετεωρολογικά δεδομένα του έτους 2014 από την περιοχή της Βοιωτίας. Τα επίγεια δεδομένα προέρχονται από τον αυτόματο αγρομετεωρολογικό σταθμό (ΑΑΣ) μέτρησης της εξατμισοδιαπνοής αναφοράς (ΕΤο) του Γεωπονικού Πανεπιστημίου Αθηνών (ΓΠΑ). Τα μετεωρολογικά δορυφορικά δεδομένα (SAT) αντιστοιχούν σε πολύγωνο 0.25οΧ0.25ο εντός του οποίου λειτουργεί και ο ΑΑΣ. Χρησιμοποιώντας τα επίγεια αλλά και τα δορυφορικά δεδομένα, υπολογίσθηκε η ΕΤο με τη μέθοδο FAO-56 PM, αλλά και με τρεις εμπειρικές μεθόδους (Copais, Valiantzas και Hargreaves-Samani) και πραγματοποιήθηκαν συγκρίσεις με σκοπό να αξιολογηθεί η αξιοπιστία των μοντέλων. Ως βάση των συγκρίσεων υιοθετήθηκε η μέθοδος FAO-56 PM με χρήση επίγειων δεδομένων. Από την εργασία προκύπτει ότι τόσο για τα επίγεια όσο και για τα δορυφορικά δεδομένα η μέθοδος Copais δίνει τις καλύτερες εκτιμήσεις ακολουθούμενη από την μέθοδο Valiantzas και με σοβαρή υπερεκτίμηση η Hargreaves-Samani. In the present study we used ground and satellite meteorological data of the year 2014 from the region of Viotia-Greece. The ground data were obtained from the automatic grass reference evapotranspiration station (AAS) of the Agricultural University of Athens. The satellite data (SAT) cover an area of 0,25ο x 0,25ο that includes the AAS. By using the ground and the satellite data we calculated the reference evapotranspiration, ΕΤο, with the method FAO-56 PM and with three empirical methods (Copais, Valiantzas and Hargreaves-Samani). The FAO-56 PM was used as a benchmark method to compare and validate the performances of the others methods. The results show that for both the ground and the satellite data, Copais method is the most accurate followed by Valiantzas and Hargreaves-Samani, indicated by serious overestimation
Mild gestational diabetes in pregnancy and the adipoinsular axis in babies born to mothers in the ACHOIS randomised controlled trial
BACKGROUND: Mild gestational diabetes is a common complication of pregnancy, affecting up to 9% of pregnant women. Treatment of mild GDM is known to reduce adverse perinatal outcomes such as macrosomia and associated birth injuries, such as shoulder dystocia, bone fractures and nerve palsies. This study aimed to compare the plasma glucose concentrations and serum insulin, leptin and adiponectin in cord blood of babies of women (a) without gestational diabetes mellitus (GDM), (b) with mild GDM under routine care, or (c) mild GDM with treatment. METHODS: 95 women with mild GDM on oral glucose tolerance testing (OGTT) at one tertiary level maternity hospital who had been recruited to the ACHOIS trial at one of the collaborating hospitals and randomised to either Treatment (n = 46) or Routine Care (n = 49) and Control women with a normal OGTT (n = 133) were included in the study. Women with mild GDM (treatment or routine care group) and OGTT normal women received routine pregnancy care. In addition, women with treated mild GDM received dietary advice, blood glucose monitoring and insulin if necessary. The primary outcome measures were cord blood concentrations of glucose, insulin, adiponectin and leptin. RESULTS: Cord plasma glucose was higher in women receiving routine care compared with control, but was normalized by treatment for mild GDM (p = 0.01). Cord serum insulin and insulin to glucose ratio were similar between the three groups. Leptin concentration in cord serum was lower in GDM treated women compared with routine care (p = 0.02) and not different to control (p = 0.11). Adiponectin was lower in both mild GDM groups compared with control (Treatment p = 0.02 and Routine Care p = 0.07), while the adiponectin to leptin ratio was lower for women receiving routine care compared with treatment (p = 0.08) and control (p = 0.05). CONCLUSION: Treatment of women with mild GDM using diet, blood glucose monitoring and insulin if necessary, influences the altered fetal adipoinsular axis characteristic of mild GDM in pregnancy
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Polycystic ovarian syndrome and pregnancy outcome
Introduction: Polycystic ovarian syndrome (PCOS) is a common disease of the endocrine system among the women of reproductive age with an incidence ranging from 5 to 10%. Method: This study is a mini-review of pregnancy and perinatal outcome in women with PCOS. Results: The syndrome is associated with increased risk of pregnancy complications such as gestational diabetes, gestational hypertension, preeclampsia, and preterm labor, while no strong association was found with congenital anomalies or spontaneous miscarriages. Furthermore, women with PCOS seem to experience increased risk of cesarean delivery while their newborns face increased perinatal morbidity and mortality. Metformin use seems to reduce the risk of obstetrical complications; however, prospective studies are necessary on the field. Conclusion: Further studies should be organised in order to evaluate the role of PCOS in pregnancy. © Springer-Verlag 2010
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