Liquid Scintillator Time Projection Chamber Concept

Results are presented from a small-scale experiment to investigate the use of room temperature organic liquid scintillators as the active medium for a time projection chamber (TPC). The optical properties of liquid scintillators have long been known, but their ability to transport charge has remained, until now, largely untested. The idea of using room temperature liquids as an active medium for an ionisation chamber was first presented in \cite{EnglerTMS}. Since then the range of liquid scintillators available has been greatly developed. We present successful transport of ionization charges in a selection of both, pure organic liquid solvents and liquid scintillator cocktails over 20$\,$mm using a variety of electric drift field strengths. The target of this research is to offer a cost effective alternative to liquid noble gas detectors in neutrino physics.Comment: 6 pages, 5 figures, submitted to Proceedings 12th Pisa Meeting on Advanced Detectors, La Biodola, Isola d'Elba, Ital

COMT val158met Polymorphism and Neural Pain Processing

A functional polymorphism (val158met) of the gene coding for Catechol-O-methyltransferase (COM) has been demonstrated to be related to processing of emotional stimuli. Also, this polymorphism has been found to be associated with pain regulation in healthy subjects. Therefore, we investigated a possible influence of this polymorphism on pain processing in healthy persons as well as in subjects with markedly reduced pain sensitivity in the context of Borderline Personality Disorder (BPD). Fifty females (25 patients with BPD and 25 healthy control participants) were included in this study. Genotype had a significant – though moderate - effect on pain sensitivity, but only in healthies. The number of val alleles was correlated with the BOLD response in several pain-processing brain regions, including dorsolateral prefrontal cortex, posterior parietal cortex, lateral globus pallidus, anterior and posterior insula. Within the subgroup of healthy participants, the number of val alleles was positively correlated with the BOLD response in posterior parietal, posterior cingulate, and dorsolateral prefrontal cortex. BPD patients revealed a positive correlation between the number of val alleles and BOLD signal in anterior and posterior insula. Thus, our data show that the val158met polymorphism in the COMT gene contributes significantly to inter-individual differences in neural pain processing: in healthy people, this polymorphism was more related to cognitive aspects of pain processing, whereas BPD patients with reduced pain sensitivity showed an association with activity in brain regions related to affective pain processing

MATRIX Reference Reports

The Multi-HAzard and MulTi-RIsK Assessment MethodS for Europe or MATRIX project (01.10.2010 to 31.12.2013), coordinated by the GFZ, set out to tackle some of the issues associated with multi-hazard and risk assessment. Disaster risk reduction (DDR) activities generally treat different natural hazards and their associated risks separately within what may be termed a "single-type" approach. However, this ignores the spatial and temporal interactions that often arise along the disaster risk chain. For instance, one hazardous event may trigger others, e.g., earthquakes causing tsunamis, or several different types may occur concurrently, e.g., severe weather and earthquakes. Considering vulnerability, an initial event would leave a community more susceptible to future, possibly different, hazards, e.g., an earthquake weakening buildings which are damaged further by windstorms. The temporal dimension may include changes in exposure, e.g., increased urbanisation, altering the total risk to an area, while repeated events lessen a community's resilience. Meanwhile, although losses are estimated by usually only considering direct economic losses or casualties, this ignores less tangible losses such as reduced business activity or the loss of cultural heritage. In short, the total risk estimated when incorporating interactions between multiple hazards and risks is likely to be greater than the sum of the individual parts. Hence, for a more comprehensive risk assessment paradigm, these, and other, interactions need to be considered. Therefore, MATRIX set out to develop concepts, methods, frameworks and tools for dealing with risk assessment within a multi-hazard and risk environment. The focus was on the hazards that most affect Europe, namely earthquakes, landslides, volcanos, tsunamis, wild fires, storms and fluvial and coastal flooding. Interactions at all the different levels were considered, such as cascading events and time dependency in vulnerability. The resulting products were applied at three test cases: Naples, Italy, the French West Indies, and Cologne, Germany. Considerable interaction with end-users was also undertaken, including identifying biases at the individual and institutional level which may hinder employing a multi-type framework for risk governance. This Scientific Technical Report presents two so-called "Reference reports" produced during the MATRIX project. These reports were provided to the European Commission as deliverables, namely D8.4 "MATRIX Results I and Reference Report" and D8.5 "MATRIX Results II and Reference Report". D8.4 presented a series of specific reports outlining the results of the project, written in a manner accessible not only to the specialist but with a broader audience in mind. D8.5 deals with the risk governance within a multi-hazard and risk context and has since been published. We therefore divide with document in two, where part 1 represented the outcomes presented in D8.4 while D8.5 forms part 2. We believe the MATRIX project was a very important step towards the goal of establishing the multi-hazard and risk environment as the norm within a European context, and we hope that the reader will benefit from the results presented here

Asthma and gender impact accumulation of T cell subtypes

<p>Abstract</p> <p>Background</p> <p>The "Th2 hypothesis for asthma" asserts that an increased ratio of Th2:Th1 cytokine production plays an important pathogenic role in asthma. Although widely embraced, the hypothesis has been challenged by various empirical observations and has been described as overly simplistic. We sought to establish whether CD3+CD28-mediated and antigen-independent accumulation of type 1 and type 2 T cells differs significantly between nonasthmatic and asthmatic populations.</p> <p>Methods</p> <p>An ex vivo system was used to characterize the regulation of IFN-γ-producing (type 1) and IL-13-producing (type 2) T cell accumulation in response to CD3+CD28 and IL-2 stimulation by flow cytometry.</p> <p>Results</p> <p>IL-13-producing T cells increased in greater numbers in response to antigen-independent stimulation in peripheral blood lymphocytes from female atopic asthmatic subjects compared with male asthmatics and both male and female atopic non-asthmatic subjects. IFN-γ⁺T cells increased in greater numbers in response to either antigen-independent or CD3+CD28-mediated stimulation in peripheral blood lymphocytes from atopic asthmatic subjects compared to non-asthmatic subjects, regardless of gender.</p> <p>Conclusions</p> <p>We demonstrate that T cells from asthmatics are programmed for increased accumulation of both type 2 and type 1 T cells. Gender had a profound effect on the regulation of type 2 T cells, thus providing a mechanism for the higher frequency of adult asthma in females.</p

Commissioning of the vacuum system of the KATRIN Main Spectrometer

The KATRIN experiment will probe the neutrino mass by measuring the beta-electron energy spectrum near the endpoint of tritium beta-decay. An integral energy analysis will be performed by an electro-static spectrometer (Main Spectrometer), an ultra-high vacuum vessel with a length of 23.2 m, a volume of 1240 m^3, and a complex inner electrode system with about 120000 individual parts. The strong magnetic field that guides the beta-electrons is provided by super-conducting solenoids at both ends of the spectrometer. Its influence on turbo-molecular pumps and vacuum gauges had to be considered. A system consisting of 6 turbo-molecular pumps and 3 km of non-evaporable getter strips has been deployed and was tested during the commissioning of the spectrometer. In this paper the configuration, the commissioning with bake-out at 300{\deg}C, and the performance of this system are presented in detail. The vacuum system has to maintain a pressure in the 10^{-11} mbar range. It is demonstrated that the performance of the system is already close to these stringent functional requirements for the KATRIN experiment, which will start at the end of 2016.Comment: submitted for publication in JINST, 39 pages, 15 figure

Detailed spectral and morphological analysis of the shell type SNR RCW 86

Aims: We aim for an understanding of the morphological and spectral properties of the supernova remnant RCW~86 and for insights into the production mechanism leading to the RCW~86 very high-energy gamma-ray emission. Methods: We analyzed High Energy Spectroscopic System data that had increased sensitivity compared to the observations presented in the RCW~86 H.E.S.S. discovery publication. Studies of the morphological correlation between the 0.5-1~keV X-ray band, the 2-5~keV X-ray band, radio, and gamma-ray emissions have been performed as well as broadband modeling of the spectral energy distribution with two different emission models. Results:We present the first conclusive evidence that the TeV gamma-ray emission region is shell-like based on our morphological studies. The comparison with 2-5~keV X-ray data reveals a correlation with the 0.4-50~TeV gamma-ray emission.The spectrum of RCW~86 is best described by a power law with an exponential cutoff at $E_{cut}=(3.5\pm 1.2_{stat})$ TeV and a spectral index of $\Gamma$~$1.6\pm 0.2$. A static leptonic one-zone model adequately describes the measured spectral energy distribution of RCW~86, with the resultant total kinetic energy of the electrons above 1 GeV being equivalent to $\sim$0.1\% of the initial kinetic energy of a Type I a supernova explosion. When using a hadronic model, a magnetic field of $B$~100$\mu$G is needed to represent the measured data. Although this is comparable to formerly published estimates, a standard E$^{-2}$ spectrum for the proton distribution cannot describe the gamma-ray data. Instead, a spectral index of $\Gamma_p$~1.7 would be required, which implies that ~$7\times 10^{49}/n_{cm^{-3}}$erg has been transferred into high-energy protons with the effective density $n_{cm^{-3}}=n/ 1$ cm^-3. This is about 10\% of the kinetic energy of a typical Type Ia supernova under the assumption of a density of 1~cm^-3.Comment: accepted for publication by A&