540 research outputs found
On a new compactification of moduli of vector bundles on a surface, IV: Nonreduced moduli
The construction for nonreduced projective moduli scheme of semistable
admissible pairs is performed. We establish the relation of this moduli scheme
with reduced moduli scheme built up in the previous article and prove that
nonreduced moduli scheme contains an open subscheme which is isomorphic to
moduli scheme of semistable vector bundles.Comment: 20 pages, additions and removal
Synthesis and characterization of ZnBTC-based MOFs: effect of solvents and salt
In this work, we studied the optimization of synthetic approaches to creating structurally modified metal-organic frameworks under various synthesis conditions. We investigated the influence of the various solvents and zinc salts on the structural characteristics of the metal-organic framework based on benzene-1,3,5-tricarboxylic acid (H3BTC). The results indicate that the variation of the types of both solvent and salt is a parameter affecting the crystallinity, phase purity, and morphology of the metal-organic framework. This was confirmed by comprehensive structural characterization (SEM, EDX, PXRD)
ΠΠ± ΠΎΠ΄Π½ΠΎΠΌ ΠΈΠ·ΠΎΠΌΠΎΡΡΠΈΠ·ΠΌΠ΅ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ ΡΡ Π΅ΠΌΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ
A morphism of the reduced GiesekerΒ - Maruyama moduli functor (of semistable coherent torsion-free sheaves) on the surface to the reduced moduli functor of admissible semistable pairs with the same Hilbert polynomial, is constructed. It is shown that main components of reduced moduli scheme for semistable admissible pairs ((eS; eL); eE) are isomorphic to main components of the reduced GiesekerΒ - Maruyama moduli scheme.ΠΠΎΡΡΡΠΎΠ΅Π½ ΠΌΠΎΡΡΠΈΠ·ΠΌ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ³ΠΎ ΡΡΠ½ΠΊΡΠΎΡΠ° ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΠ° β ΠΠ°ΡΡΡΠΌΡ (ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΡΡ
ΠΏΡΡΠΊΠΎΠ² Π±Π΅Π· ΠΊΡΡΡΠ΅Π½ΠΈΡ) Π½Π° ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΠΉ ΡΡΠ½ΠΊΡΠΎΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π΄ΠΎΠΏΡΡΡΠΈΠΌΡΡ
ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΏΠ°Ρ c ΡΠ΅ΠΌ ΠΆΠ΅ ΠΏΠΎΠ»ΠΈΠ½ΠΎΠΌΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΡΠ°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΉ ΡΡ
Π΅ΠΌΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
Π΄ΠΎΠΏΡΡΡΠΈΠΌΡΡ
ΠΏΠ°Ρ ((S; L); E) ΠΈΠ·ΠΎΠΌΠΎΡΡΠ½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ°ΠΌ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΠΎΠΉ ΡΡ
Π΅ΠΌΡ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΠ° β ΠΠ°ΡΡΡΠΌΡ
ΠΠ·ΠΎΠΌΠΎΡΡΠΈΠ·ΠΌ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ: Π½Π΅ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΡΡ Π΅ΠΌΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ
We continue the study of the compactiο¬cation of the moduli scheme for Gieseker-semistable vectorΒ bundles on a nonsingular irreducible projective algebraic surface S with polarization L, by locally freeΒ sheaves. The relation of main components of the moduli functor or admissible semistable pairs and mainΒ components of the Gieseker β Maruyama moduli functor (for semistable torsion-free coherent sheaves)Β with the same Hilbert polynomial on the surface S is investigated.Β The compactiο¬cation of interest arises when families of Gieseker-semistable vector bundles E on theΒ nonsingular polarized projective surface (S, L) are completed by vector bundles E on projective polarizedΒ schemes (S, L) of special form. The form of the scheme S, of its polarization L and of the vector bundleΒ E is described in the text. The collection ((S, L), E) is called a semistable admissible pair. VectorΒ bundles E on the surface (S, L) and E on schemes (S, L) are supposed to have equal ranks and HilbertΒ polynomials which are compute with respect to polarizations L and L, respectively. Pairs of the formΒ ((S, L), E) named as S-pairs are also included into the class under the scope. Since the purpose is toΒ study the compactiο¬cation of moduli space for vector bundles, only families which contain S-pairs areΒ considered.Β We build up the natural transformation of the moduli functor for admissible semistable pairs to theΒ Gieseker β Maruyama moduli functor for semistable torsion-free coherent sheaves on the surface (S, L),Β with same rank and Hilbert polynomial. It is demonstrated that this natural transformation is inverseΒ to the natural transformation built in the preceding paper and deο¬ned by the standard resolutionΒ of a family of torsion-free coherent sheaves with a possibly nonreduced base scheme. The functorialΒ isomorphism constructed determines the scheme isomorphism of compactiο¬cations of moduli space forΒ semistable vector bundles on the surface (S, L).Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΎ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΡΡ
Π΅ΠΌΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΏΠΎ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΡΒ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ Π½Π° Π½Π΅ΠΎΡΠΎΠ±ΠΎΠΉ Π½Π΅ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΠΏΡΠΎΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ Π°Π»Π³Π΅Π±ΡΠ°ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ S ΡΒ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠ΅ΠΉ L, Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎ ΡΠ²ΠΎΠ±ΠΎΠ΄Π½ΡΠΌΠΈ ΠΏΡΡΠΊΠ°ΠΌΠΈ. ΠΡΡΠ»Π΅Π΄ΡΠ΅ΡΡΡ ΡΠ²ΡΠ·Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ ΡΡΠ½ΠΊΡΠΎΡΠ°Β ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π΄ΠΎΠΏΡΡΡΠΈΠΌΡΡ
ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΏΠ°Ρ ΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½Ρ ΡΡΠ½ΠΊΡΠΎΡΠ° ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΠ° βΠΠ°ΡΡΡΠΌΡ (ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΡΡ
ΠΏΡΡΠΊΠΎΠ² Π±Π΅Π· ΠΊΡΡΡΠ΅Π½ΠΈΡ) Ρ ΡΠ΅ΠΌ ΠΆΠ΅ ΠΏΠΎΠ»ΠΈΠ½ΠΎΠΌΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΡΠ° Π½Π°Β ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ S.Β Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΠΌΠ°Ρ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΠΎΠ»ΡΡΠ°Π΅ΡΡΡ, Π΅ΡΠ»ΠΈ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΏΠΎ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΡΒ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ E Π½Π° ΠΏΠΎΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π΅ΠΎΡΠΎΠ±ΠΎΠΉ ΠΏΡΠΎΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ (S,L) ΠΏΠΎΠΏΠΎΠ»Π½ΡΡΡΡΡ Π²Π΅ΠΊΡΠΎΡΠ½ΡΠΌΠΈ ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΡΠΌΠΈ E Π½Π° ΠΏΡΠΎΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΏΠΎΠ»ΡΡΠΈΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΡΡ
Π΅ΠΌΠ°Ρ
(S,L) ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎΒ Π²ΠΈΠ΄Π°. ΠΠΈΠ΄ ΡΡ
Π΅ΠΌΡ S, ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΈ L ΠΈ ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΡ E ΠΎΠΏΠΈΡΠ°Π½ Π² ΡΠ΅ΠΊΡΡΠ΅ ΡΠ°Π±ΠΎΡΡ. ΠΠ°Π±ΠΎΡ ((S,L),E)Β Π½Π°Π·Π²Π°Π½ ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΠΉ Π΄ΠΎΠΏΡΡΡΠΈΠΌΠΎΠΉ ΠΏΠ°ΡΠΎΠΉ. ΠΠ΅ΠΊΡΠΎΡΠ½ΡΠ΅ ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΡ E Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ (S,L) ΠΈ EΒ Π½Π° ΡΡ
Π΅ΠΌΠ°Ρ
(S,L) ΠΏΡΠ΅Π΄ΠΏΠΎΠ»Π°Π³Π°ΡΡΡΡ ΠΈΠΌΠ΅ΡΡΠΈΠΌΠΈ ΡΠ°Π²Π½ΡΠ΅ ΡΠ°Π½Π³ΠΈ ΠΈ ΠΏΠΎΠ»ΠΈΠ½ΠΎΠΌΡ ΠΠΈΠ»ΡΠ±Π΅ΡΡΠ°, Π²ΡΡΠΈΡΠ»ΡΠ΅ΠΌΡΠ΅Β ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ»ΡΡΠΈΠ·Π°ΡΠΈΠΉ L ΠΈ L ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ. ΠΠ°ΡΡ Π²ΠΈΠ΄Π° ((S,L),E), Π½Π°Π·ΡΠ²Π°Π΅ΠΌΡΠ΅ S-ΠΏΠ°ΡΠ°ΠΌΠΈ,Β ΡΠ°ΠΊΠΆΠ΅ Π²Ρ
ΠΎΠ΄ΡΡ Π² ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°Π΅ΠΌΡΠΉ ΠΊΠ»Π°ΡΡ. ΠΠΎΡΠΊΠΎΠ»ΡΠΊΡ ΡΠ΅Π»ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π° ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ, ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠΎΠ»ΡΠΊΠΎ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π°,Β ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠ΅ S-ΠΏΠ°ΡΡ.Β ΠΠΎΡΡΡΠΎΠ΅Π½ΠΎ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΎΡΠ° ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ Π΄ΠΎΠΏΡΡΡΠΈΠΌΡΡ
ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΏΠ°ΡΒ Π² ΡΡΠ½ΠΊΡΠΎΡ ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΠΈΠ·Π΅ΠΊΠ΅ΡΠ° β ΠΠ°ΡΡΡΠΌΡ ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΡΡ
ΠΏΡΡΠΊΠΎΠ² Π±Π΅Π· ΠΊΡΡΡΠ΅Π½ΠΈΡ Π½Π°Β ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ (S,L), ΠΈΠΌΠ΅ΡΡΠΈΡ
ΡΠ΅ ΠΆΠ΅ ΡΠ°Π½Π³ ΠΈ ΠΏΠΎΠ»ΠΈΠ½ΠΎΠΌ ΠΠΈΠ»ΡΠ±Π΅ΡΡΠ°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΠΎ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅Β ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ Π΄Π²ΡΡΡΠΎΡΠΎΠ½Π½ΠΈΠΌ ΠΎΠ±ΡΠ°ΡΠ½ΡΠΌ ΠΊ Π΅ΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΌΡ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΏΠΎΡΡΡΠΎΠ΅Π½Π½ΠΎΠΌΡ Π² ΠΏΡΠ΅Π΄ΡΠ΅ΡΡΠ²ΡΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΠ΅ ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΠΎΠΌΡ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΡΠΌ ΡΠ°Π·ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° ΠΊΠΎΠ³Π΅ΡΠ΅Π½ΡΠ½ΡΡ
Β ΠΏΡΡΠΊΠΎΠ² Π±Π΅Π· ΠΊΡΡΡΠ΅Π½ΠΈΡ, ΠΈΠΌΠ΅ΡΡΠ΅Π³ΠΎ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ Π½Π΅ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Π½ΡΡ Π±Π°Π·ΠΈΡΠ½ΡΡ ΡΡ
Π΅ΠΌΡ. ΠΠΎΡΡΡΠΎΠ΅Π½Π½ΡΠΉ ΠΈΠ·ΠΎΠΌΠΎΡΡΠΈΠ·ΠΌ ΡΡΠ½ΠΊΡΠΎΡΠΎΠ² ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΠΈΠ·ΠΎΠΌΠΎΡΡΠΈΠ·ΠΌ ΠΊΠΎΠΌΠΏΠ°ΠΊΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΉ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π° ΠΌΠΎΠ΄ΡΠ»Π΅ΠΉ ΠΏΠΎΠ»ΡΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΡ
Π²Π΅ΠΊΡΠΎΡΠ½ΡΡ
ΡΠ°ΡΡΠ»ΠΎΠ΅Π½ΠΈΠΉ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ (S,L) ΠΊΠ°ΠΊ Π°Π»Π³Π΅Π±ΡΠ°ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡ
Π΅ΠΌ
Effect of nitric acid modification of montmorillonite clay on synthesis of solketal from glycerol and acetone
[EN]The effect of acid modification of a natural montmorillonite clay (MM) by HNO3 on the catalytic properties of MM from Dash-Salakhlinsk (Kazakhstan) has been investigated in the synthesis of solketal from glycerol and acetone in solvent free and acetonitrile media. HNO3 concentration allowed to control the chemical composition, the surface acidity, the porous structure of the acid-activated MMs and their catalytic performance. The main reaction product was solketal with 86.6β98% selectivity. Conversion of glycerol depended on the BrΓΈnsted acidity. The most active sample, namely, MM activated with 0.5 mol/dm3 HNO3, showed good reusability for 3 catalyst cycle
Methods of probe microscopy in the study of topography and elastic properties of cold-resistant elastomers
The work was carried out under the financial support of the Russian Science Fund, grant 14-29-00198-Π(sample preparation and scanning electron microscopy) and the Federal Agency of Scientific Organizations - Agreement No 007-ΠΠ/Π§3363/26 (scanning probe microscopy)
About some economic applications of cohort analysis
Nowadays, there is the problem of evaluating the return on advertising costs for industries with a delayed conversion. Cohort analysis is a series of studies which are conducted at certain time intervals. Using cohort analysis we can better assess the effectiveness of advertising channels for industries with a delayed conversion. Cohort analysis can be used to analyze following items: efficiency in the context of "traffic sources", usefulness of changes on the web site; assessment of effectiveness of marketing campaigns; assessment of impact of seasonality on the behavior of the user; the decision-making period. The article presents an overview of tools we can use to collect data for analysis. The article also describes the method of selection and the variants of the cohorts to construct the analysis. For demonstration of the proposed method and calculation variant, there is considered the practical example of building a cohort analysis. Using these method and the example of calculating, the companies with delayed conversion can analyze the effectiveness of Internet advertising for different advertising channels. Β© 2018 Author(s)
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STRA13 Interacts with STAT3 and Modulates Transcription of STAT3-dependent Targets
STRA13 is a pVHL-dependent bHLH transcription factor up-regulated on the mRNA level in multiple cancer cell lines and implicated recently in the regulation of immune cell homeostasis and autoimmunity. In searching for STRA13-interacting proteins with oncogenic potential by the yeast two-hybrid screening, we identified STAT3Ξ² as a STRA13-binding partner. We showed that STRA13 binds predominantly to phosphorylated (active) STAT3 Ξ± and Ξ² isoforms via its HLH and C-terminal regions. We also found that STRA13 was able to activate transcription from STAT-dependent cis-elements. Expression of endogenous STRA13 was shown to be cytokine-inducible, consistent with STRA13 involvement in STAT-dependent transcription regulation. We demonstrated that the STAT3-regulated promoter of the pro-apoptotic Fas gene was activated upon STRA13 over-expression and that co-expression of STRA13 with STAT3Ξ² or STAT3Ξ± modulated the transcriptional outcome. Forced expression of STRA13 induced apoptosis, in agreement with the STRA13 activation effect on the Fas promoter. Simultaneous expression of STRA13 and STAT3Ξ² resulted in alleviation of the STRA13 pro-apoptotic effect. Thus, for the first time, we identify STRA13 as a STAT3 partner and provide a consistent line of evidence for STRA13 involvement into regulation of apoptosis via the STAT pathways
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