Роль газових медіаторів: нітрогену оксиду та гідрогену сульфіду в тонкій кишці щурів за умов інгібуванняциклооксигенази і ліпооксигенази

Inexperimentstherewerecomparedthecyclooxygenaseinhibitionbyindomethacinanddualcycloocygenaseandlipoxygenaseblockageby 4-thiazolidinonederivatives, capabletoreleasehydrogensulfidein small intestine. Itwasshownthatindomethacinwasaccompaniedbytheformationoflesions in the distal part ofsmall intestine, significantactivationofinducibleNO-synthase, thedecreaseofH2Sproduction, riseinmalonicdialdehydeconcentrationand activity of myeloperoxidase. Theadministrationof5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-thyoxo-thiazolidine-2-onand 2-[(4-chlor-phenyl-carbamoyl)-methyl]-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-acrylicaciddidn’tdemonstrateanulcerogenicactioninsmallintestine, thatwasprobablycausedbythereleaseofH2S from these compounds.экспериментахмысравниваливлияниеингибированияциклооксигеназыиндометацином и совмещенногоблокированияциклооксигеназы и липооксигеназыпроизводными 4-тиазолидинона, чтовысвобождают H2S в слизистойоболочкетонкой кишки.Обнаружили, чтодействиеиндометацинасопровождалосьформированием структурно-геморрагическихповреждений,значительнойактивациейиндуцибельной NO-синтазы, снижениемконцентрации H2S, ростом концентрации ТБК-активныхпродуктов и активностимиелопероксидазы.Использованиесоединений 5-(3,5-дитерт-бутил-4-гидроксибензилиден)-4-тиоксо-тиазолидин-2-он и 2-[(4-хлор-фенилкарбамоил)-метил]-3-(3,5-дитертбутил-4-гидроксифенил)-акриловой кислоты не оказывалоульцерогенногодействия в слизистойоболочкетонкой кишки, что, вероятно, былообусловленовысвобождениемиз них H2S.В експериментах ми порівнювали вплив інгібуванняциклооксигеназиіндометациномі поєднаного блокування циклооксигенази та ліпооксигенази похідними 4-тіазолідинону, що вивільняють H2Sу слизовій оболонці тонкої кишки. Виявили, що дія індометацину супроводжувалась формуванням структурно-геморагічних ушкоджень, значною активацією індуцибельноїNO-синтази, зниженням концентрації H2S, зростанням концентрації ТБК-активних продуктів та активності мієлопероксидази. Використання сполук 5-(3,5-дитерт-бутил-4-гідроксибензиліден)-4-тіоксо-тіазолідин-2-он та 2-[(4-хлор-фенілкарбамоїл)-метил]-3-(3,5-дитертбутил-4-гідроксифеніл)-акрилової кислоти не чинило ульцерогенної дії в слизовій оболонці тонкої кишки, що, ймовірно, було зумовлено вивільненням з них H2S

Гипертекстуализация библиотечно-информационной образовательной деятельности как условие реализации Федерального государственного образовательного стандарта

Information structuring is seen as an efficient way to develop social communication. The study task is to reveal theoretical and technological background of hypertextualization of library and information educational environment. The substance, functions, structural elements of hypertext and its advantages for social communication are described. Specifications of using hypertext technologies for education are discussed, along with principles of hypertext design and perception via digital academic complex, digital textbooks, digital bibliographies as the multifunctional open subsystems of digital learning materials interrelated structurally and methodologically in the library and information disciplines.The authors analyzee the experience of Belgorod State Institute of Arts and Culture in designing hypertext resource providing the completeness, accessibility and relevance of using information educational resources and information communication technologies in every type of learning activities. These efforts are seen by the faculty as one of the ways to support professional education methodologically.Статья посвящена структурированию информации, гипертекстовому режиму как одному из способов эффективного освоения социальной коммуникации. Цель исследования – раскрытие теоретических и технологических основ гипертекстуализации библиотечно-информационной образовательной среды как условие реализации Федерального государственного образовательного стандарта. Рассмотрены сущность, функции, структурные единицы гипертекста, его преимущества при социальной коммуникации. Обозначены особенности использования гипертекстовых технологий при обучении. Изложены принципы создания и восприятия гипертекстов через электронные учебно-методические комплексы, электронные учебники, электронные библиографические пособия как многофункциональные открытые подсистемы взаимосвязанных в содержательном и методическом отношении электронных учебных материалов по направлению подготовки «Библиотечно-информационная деятельность». Представлена характеристика деятельности профильной кафедры Белгородского государственного института искусств и культуры по разработке гипертекстового ресурса, обеспечивающего полноту, доступность и оперативность использования информационных образовательных ресурсов и информационно-коммуникационных технологий во всех видах учебной деятельности, что направлено на повышение производительности профессиональной деятельности педагога и самостоятельной деятельности обучающегося. Работа по созданию образовательных ресурсов рассматривается преподавателями кафедры как одна из возможностей учебнометодического обеспечения профессионального образования

A global outlook to the interruption of education due to COVID-19 Pandemic: Navigating in a time of uncertainty and crisis

Uncertain times require prompt reflexes to survive and this study is a collaborative reflex to better understand uncertainty and navigate through it. The Coronavirus (Covid-19) pandemic hit hard and interrupted many dimensions of our lives, particularly education. As a response to interruption of education due to the Covid-19 pandemic, this study is a collaborative reaction that narrates the overall view, reflections from the K12 and higher educational landscape, lessons learned and suggestions from a total of 31 countries across the world with a representation of 62.7% of the whole world population. In addition to the value of each case by country, the synthesis of this research suggests that the current practices can be defined as emergency remote education and this practice is different from planned practices such as distance education, online learning or other derivations. Above all, this study points out how social injustice, inequity and the digital divide have been exacerbated during the pandemic and need unique and targeted measures if they are to be addressed. While there are support communities and mechanisms, parents are overburdened between regular daily/professional duties and emerging educational roles, and all parties are experiencing trauma, psychological pressure and anxiety to various degrees, which necessitates a pedagogy of care, affection and empathy. In terms of educational processes, the interruption of education signifies the importance of openness in education and highlights issues that should be taken into consideration such as using alternative assessment and evaluation methods as well as concerns about surveillance, ethics, and data privacy resulting from nearly exclusive dependency on online solutions

Стан системи NO-синтаза/аргіназа плазми крові та лімфоцитів у жінок із непліддям та аскаридозом

The status of the system NO-synthase/arginase and oxidative processes in blood plasma and lymphocytes lysate in healthy women, women with primary infertility without ascariasis and women with primary infertility and ascariasis was investigated. Obtained data show the increase of eNOS activity in lymphocytes lysate of women with primary infertility. We revealed no significant changes of NO-synthase and arginase activity in lymphocytes lysate and oxidative processes in blood plasma and lymphocytes lysate in women with primary infertility and ascariasis.Показаны изменения состояния системы NO-синтаза/аргиназа и оксидативных процессов в плазме крови и лизате лимфоцитов у здоровых женщин, женщин с первичным бесплодием без аскаридоза и женщин с первичным бесплодием с аскаридозом. Полученные данные свидетельствуют о повышении в лизате лимфоцитов женщин с первичным бесплодием активности еNOS. Выраженных изменений активности NO-синтазы и аргиназы в лизате лимфоцитов и оксидативных процессов в плазме крови и лизате лимфоцитов у женщин с первичным бесплодием с аскаридозом не выявлено.Досліджено стан системи NO-синтаза/аргіназа та оксидативних процесів у плазмі крові та лізаті лімфоцитів у здорових жінок, жінок із первинним непліддям без аскаридозу й жінок із первинним непліддям та аскаридозом. Отримані дані свідчать про зростання в лізаті лімфоцитів жінок із первинним непліддям активності еNOS. Виражених змін NO-синтаз та аргінази в лізаті лімфоцитів та оксидативних процесів у плазмі крові та лізаті лімфоцитів у жінок із первинним непліддям та аскаридозом не виявлено

OCT-Angiography in Early Choroidal Melanoma and Choroidal Nevi

Purpose: To study the features of small choroidal melanoma and choroidal nevi angioarchitectonics using the optical coherence tomography angiography (OCTA).Patients and methods. We examined 128 patients with small choroidal neoplasms: 41 — with small choroidal melanoma (group 1), 42 — with suspicious nevi (group 2) and 45 — with benign nevi (group 3). All patients underwent general ophthalmic examinations and special instrumental diagnostic methods (ultrasound examination (US), fluorescence angiography (FA), spectral optical coherence tomography (SOCT), OCTA).Results. OCTA in all patients with small choroidal melanoma showed neovascular network under retinal pigment epithelium. We found a looped, cranked-twisted, heterogeneous vascular network with uneven clearance and with numerous bends and weaves, located under the vessels of retina. The limiting avascular zone corresponding to the tumor slope was determined in 19 (46.3 %) of 41 cases. There was a rim of dilated hyperreflective choriocapillaries on the periphery of the tumor. We identified hyperreflective homogeneous enlarged choriocapillaries in the focus area with a brighter glow than the surrounding choriocapillaries in 39 (92.9 %) of 42 patients with suspicious choroidal nevus. We detected an avascular zone with surrounding extended hyperreflective choriocapillaries in the center of the nevus in 3 (7.1 %) of 42 cases. We diagnosed homogeneous isoreflective choriocapillaries similar in brightness to the surrounding vessels in all 45 patients with benign nevi.Conclusions. Thus, the complex of clinical and instrumental methods, including OCTA, makes it possible to establish the diagnosis of malignant tumor of the choroid in early stages. At the same time, OCTA: 1) allows to visualize of the tumor vessels in the choroidal layer in 100 % of cases of in small choroidal melanoma; 2) makes it possible to distinguish the newly formed tumor vessels from the choriocapillaries in case of small choroidal melanoma; 3) provides an opportunity to establish the correct diagnosis and provide timely assistance to patients with benign and malignant choroidal tumors

The effect of prolonged oxygen therapy on the clinical course of the disease and diaphragm function in patients with chronic obstructive pulmonary disease and hypoxemic respiratory failure (three-year follow-up)

The objective: to determine the effect of prolonged oxygen therapy (POT) on changes in the clinical and functional status of patients with chronic obstructive pulmonary disease (COPD) and severe hypoxemic chronic respiratory failure.Subjects and methods. 30 patients with COPD were examined during the period of remission of the disease, the average age was 64.8 ± 6.9 years. After the initial examination, patients were prescribed POT at home for 16 hours/day. As a basic therapy, all patients received a combined bronchodilator of long-acting indacaterol/glycopyrronium at a dose of 110/50 μg once a day in combination with beclomethasone dipropionate (BDP) at the dose of 200-400 μg/day. The patients were examined repeatedly 3 times with a 1-year interval. Clinical indicators, gas composition of arterial blood, results of spirometry and ultrasound examination of the diaphragm were evaluated.Results. Initially, disorders of the functional state of the diaphragm were detected in COPD patients with hypoxemia (decrease in the thickening fraction and relaxation rate). After the first year of using POT, an increase in the rates of contraction and relaxation of the diaphragm muscle under tidal respiration was observed. On the 2nd and 3rd year of using POT, it was noted that indicators of the functional state of the diaphragm stabilized. As a result of POT, the number of exacerbations went down and mortality in COPD patients with hypoxemia decreased. Against the background of basic therapy with indacaterol/glycopyrronium in combination with low doses of BDP, no adverse events were observed for the entire period of follow-up.Conclusions. POT in combination with a double long-acting bronchodilator and low-dose inhaled glucocorticosteroids in COPD patients with hypoxemic chronic respiratory failure helps to reduce dyspnea, the number of severe exacerbations, as well as improve pulmonary ventilation functions, blood gas content, and the diaphragm function during the first year of its use. Further, the indicators continued to stabilize

Simultaneous topography-guided photorefractive keratectomy with accelerated collagen cross-linking in the treatment of stage I keratoconus

Purpose: to evaluate the efficiency of simultaneous topography-guided photorefractive keratectomy (PRK) with accelerated collagen cross-linking in the treatment of stage I keratoconus.Material and methods. 38 patients (49 eyes) aged 18 to 44 with stage I keratoconus were treated with simultaneous topography-guided PRK combined with accelerated corneal collagen crosslinking. Along with standard ophthalmological testing, patients underwent aberrometry, confocal microscopy, optical coherence tomography of the cornea, imaging of the anterior eye section on a Scheimpflug analyzer, and examination of the biomechanical properties of the cornea. The follow-up period was 2 years.Results. Two years after surgery, uncorrected visual acuity which originally was 0.23 ± 0.03 showed a statistically significant increase and reached 0.72 ± 0.02; best corrected visual acuity improved from 0.44 ± 0.03 to 0.89 ± 0.02; the refractive power of the cornea fell from 45.03 ± 0.28 to 42.55 ± 0.31 D; the spherical component of refraction reduced from -2.00 ± 0.19 to -0.73 ± 0.09 D; the cylinder component reduced from 2.46 ± 0.14 to 0.79 ± 0.07 mm, the thinnest point of the cornea reduced from 486.30 ± 4.78 to 406.80 ± 6.51 μm. The highest order aberrations showed the following results: Coma index reduced from 0.27 ± 0.12 to 0.08 ± 0.07, Tilt reduced from 0.53 ± 0.11 to 0.10 ± 0,09, and Trefoil reduced from 0.13 ± 0.04 to 0.05 ± 0.02.Conclusion. The analysis of clinical and functional results, biomechanical properties and structures of the cornea confirmed the efficacy and safety of the combined treatment of patients with stage I keratoconus

Correction of microbiocenosis of female reproductive tract during the late stage of pregnancy

Pobedi str., 85, Belgorod, Russia, 308024 Bacteriological examination of cervical canal at 34 women in 38—40 weeks of gestation has been made before and after intravaginal usage of Gynoflor (“Medinova”, Switzerland), containing 50 mg of Lactobacillus acidophilius and 0,03 mg of estriol. It is established, that after usage of Gynoflor significant decrease of number of patients with Staphylococcus epidermidis and Peptococcus has been observed. Furthermore, lowering of number of women with other opportunistic bacteria and yeasts ( Staphylococcus aureus , Klebsiella pneumonia , Enterococcus , Enterobacter , Streptococcus , Bacteroides , Candida albicans ) has been appeared. It was accompanied with decrease of colony forming units number among all opportunistic species