6 research outputs found
''Amis du monde'' : un projet collaboratif
Notre proposition dâintervention a comme but de montrer et de faire connaĂźtre un projet collaboratif dont les acteurs principaux ont Ă©tĂ© des Ă©tudiants du Centre dâEnseignement de Langues ĂtrangĂšres â Didaskaleio â de lâUniversitĂ© nationale et capodistrienne dâAthĂšnes. Ce projet a Ă©tĂ© rĂ©alisĂ© dans le but de participer au Concours « Amis du Monde » organisĂ© par lâAPF-fu (GrĂšce) et la Commission de lâEurope de lâOuest (CEO) pendant lâannĂ©e universitaire 2015-2016. La production conçue et rĂ©alisĂ©e par les Ă©tudiant-e-s sâinscrit dans le cadre de la perspective actionnelle (« je prĂ©fĂšre personnellement âperspective actionnelleâ Ă âapproche actionnelleâ », Puren, 2011 : 7) et de lâenseignement collaboratif Ă des fins Ă©ducatives ; lâapprentissage de la langue française Ă travers la mise en prioritĂ© des objectifs communicatifs et socio-humanistes ; ces derniers renvoyant aux approches plurielles en classe de langue et Ă lâinterculturalitĂ©. Le projet « Amis du Monde » a Ă©tĂ© lâopportunitĂ© pour les Ă©tudiante-s de se sensibiliser en ce qui concerne les rĂ©fugiĂ©s qui ont quittĂ© la Syrie et qui sont arrivĂ©s en GrĂšce, il y a sept mois. Ainsi, ils ont donnĂ© naissance Ă une Ćuvre, en langue française, aprĂšs avoir suivi toute une dĂ©marche de collecte de matĂ©riel, de recherche bibliographique ainsi que de conception sur le contenu de la production-vidĂ©o. La participation des Ă©tudiant-e-s au concours, a contribuĂ© au renforcement de lâesprit dâĂ©quipe tant des Ă©tudiants que des enseignants, Ă la collaboration entre les enseignants et les Ă©tudiants afin de crĂ©er un produit en langue cible ainsi quâĂ lâautonomie de lâapprenant en langue Ă©trangĂšre. Ă part lâactualitĂ© qui a beaucoup motivĂ© les Ă©tudiants Ă sâoccuper de ce projet, ce sont aussi les enseignants qui les ont conduits Ă la signature dâun contrat pĂ©dagogique â de façon implicite â qui mettait en valeur des objectifs sociaux, communicatifs toujours caractĂ©risĂ©s de ce qui nous semble ĂȘtre indispensable en pĂ©dagogie et en classe de langue, câest-Ă -dire dâune certaine humanitĂ© qui met au centre de lâaction lâĂȘtre humain et qui contribue Ă la connaissance de lâAutre. Par cette prĂ©sentation, nous voulons partager avec vous tant des tĂ©moignages des Ă©tudiant-e-s que leur production, mais nous avons aussi le but de montrer en dĂ©tail lâapproche humaniste qui a Ă©tĂ© suivie pour lâaccomplissement de ce projet collaboratif par un public adulte, universitaire
Hepatic steatosis in patients with acromegaly
Objective
Comorbid NAFLD is increasingly being diagnosed in patients with diabetes and nondiabetic endocrinopathies. The aim of this study was to assess hepatic steatosis noninvasively by transient elastography in patients with acromegaly.
Design
A crossâsectional study including 22 patients with acromegaly.
Methods
Hepatic steatosis was quantified using controlled attenuation parameter (CAP) during elastography. Anthropometric measurements were obtained, serum liver function tests and lipid and hormone profiles were measured, and prosteatogenic gene variants were genotyped using standard assays.
Results
In total, 41% of patients were women (mean age 60 ± 14.7 years, mean BMI 31.2 ± 4.6 kg/m2). Hepatic steatosis, as defined by CAP > 248 dB/m, was present in 66% of patients. Five (45%) of the patients with hepatic steatosis also had fibrosis, and one presented with cirrhosis. Nine patients were carriers of the PNPLA3 p.I148M prosteatogenic [M] risk allele, eight of whom were heterozygotes. CAP values were significantly (P = .045) higher in these patients and corresponded to advanced steatosis, as compared to patients with the wildâtype genotype, who demonstrated CAP values consistent with mild steatosis (311 ± 33 dB/m. vs 254 ± 62 dB/m). CAP values did not differ significantly in carriers of distinct TM6SF2 and MBOAT7 genotypes; however, carriers of the risk alleles displayed higher CAP as compared to wildâtype patients.
Conclusions
This study shows that in patients with acromegaly, carriers of the PNPLA3 susceptibility allele are at risk of developing hepatic steatosis, as assessed by CAP. Comorbid NAFLD might compound prognosis in such patients; thus, further research into the pathomechanisms and treatment of NAFLD in acromegaly is warranted
Hepatic steatosis in patients with acromegaly
Objective
Comorbid NAFLD is increasingly being diagnosed in patients with diabetes and nondiabetic endocrinopathies. The aim of this study was to assess hepatic steatosis noninvasively by transient elastography in patients with acromegaly.
Design
A crossâsectional study including 22 patients with acromegaly.
Methods
Hepatic steatosis was quantified using controlled attenuation parameter (CAP) during elastography. Anthropometric measurements were obtained, serum liver function tests and lipid and hormone profiles were measured, and prosteatogenic gene variants were genotyped using standard assays.
Results
In total, 41% of patients were women (mean age 60 ± 14.7 years, mean BMI 31.2 ± 4.6 kg/m2). Hepatic steatosis, as defined by CAP > 248 dB/m, was present in 66% of patients. Five (45%) of the patients with hepatic steatosis also had fibrosis, and one presented with cirrhosis. Nine patients were carriers of the PNPLA3 p.I148M prosteatogenic [M] risk allele, eight of whom were heterozygotes. CAP values were significantly (P = .045) higher in these patients and corresponded to advanced steatosis, as compared to patients with the wildâtype genotype, who demonstrated CAP values consistent with mild steatosis (311 ± 33 dB/m. vs 254 ± 62 dB/m). CAP values did not differ significantly in carriers of distinct TM6SF2 and MBOAT7 genotypes; however, carriers of the risk alleles displayed higher CAP as compared to wildâtype patients.
Conclusions
This study shows that in patients with acromegaly, carriers of the PNPLA3 susceptibility allele are at risk of developing hepatic steatosis, as assessed by CAP. Comorbid NAFLD might compound prognosis in such patients; thus, further research into the pathomechanisms and treatment of NAFLD in acromegaly is warranted