6 research outputs found

    ''Amis du monde'' : un projet collaboratif

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    Notre proposition d’intervention a comme but de montrer et de faire connaĂźtre un projet collaboratif dont les acteurs principaux ont Ă©tĂ© des Ă©tudiants du Centre d’Enseignement de Langues ÉtrangĂšres – Didaskaleio – de l’UniversitĂ© nationale et capodistrienne d’AthĂšnes. Ce projet a Ă©tĂ© rĂ©alisĂ© dans le but de participer au Concours « Amis du Monde » organisĂ© par l’APF-fu (GrĂšce) et la Commission de l’Europe de l’Ouest (CEO) pendant l’annĂ©e universitaire 2015-2016. La production conçue et rĂ©alisĂ©e par les Ă©tudiant-e-s s’inscrit dans le cadre de la perspective actionnelle («  je prĂ©fĂšre personnellement “perspective actionnelle” Ă  “approche actionnelle” », Puren, 2011 : 7) et de l’enseignement collaboratif Ă  des fins Ă©ducatives ; l’apprentissage de la langue française Ă  travers la mise en prioritĂ© des objectifs communicatifs et socio-humanistes ; ces derniers renvoyant aux approches plurielles en classe de langue et Ă  l’interculturalitĂ©. Le projet « Amis du Monde » a Ă©tĂ© l’opportunitĂ© pour les Ă©tudiante-s de se sensibiliser en ce qui concerne les rĂ©fugiĂ©s qui ont quittĂ© la Syrie et qui sont arrivĂ©s en GrĂšce, il y a sept mois. Ainsi, ils ont donnĂ© naissance Ă  une Ɠuvre, en langue française, aprĂšs avoir suivi toute une dĂ©marche de collecte de matĂ©riel, de recherche bibliographique ainsi que de conception sur le contenu de la production-vidĂ©o. La participation des Ă©tudiant-e-s au concours, a contribuĂ© au renforcement de l’esprit d’équipe tant des Ă©tudiants que des enseignants, Ă  la collaboration entre les enseignants et les Ă©tudiants afin de crĂ©er un produit en langue cible ainsi qu’à l’autonomie de l’apprenant en langue Ă©trangĂšre. À part l’actualitĂ© qui a beaucoup motivĂ© les Ă©tudiants Ă  s’occuper de ce projet, ce sont aussi les enseignants qui les ont conduits Ă  la signature d’un contrat pĂ©dagogique – de façon implicite – qui mettait en valeur des objectifs sociaux, communicatifs toujours caractĂ©risĂ©s de ce qui nous semble ĂȘtre indispensable en pĂ©dagogie et en classe de langue, c’est-Ă -dire d’une certaine humanitĂ© qui met au centre de l’action l’ĂȘtre humain et qui contribue Ă  la connaissance de l’Autre. Par cette prĂ©sentation, nous voulons partager avec vous tant des tĂ©moignages des Ă©tudiant-e-s que leur production, mais nous avons aussi le but de montrer en dĂ©tail l’approche humaniste qui a Ă©tĂ© suivie pour l’accomplissement de ce projet collaboratif par un public adulte, universitaire

    Hepatic steatosis in patients with acromegaly

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    Objective Comorbid NAFLD is increasingly being diagnosed in patients with diabetes and nondiabetic endocrinopathies. The aim of this study was to assess hepatic steatosis noninvasively by transient elastography in patients with acromegaly. Design A cross‐sectional study including 22 patients with acromegaly. Methods Hepatic steatosis was quantified using controlled attenuation parameter (CAP) during elastography. Anthropometric measurements were obtained, serum liver function tests and lipid and hormone profiles were measured, and prosteatogenic gene variants were genotyped using standard assays. Results In total, 41% of patients were women (mean age 60 ± 14.7 years, mean BMI 31.2 ± 4.6 kg/m2). Hepatic steatosis, as defined by CAP > 248 dB/m, was present in 66% of patients. Five (45%) of the patients with hepatic steatosis also had fibrosis, and one presented with cirrhosis. Nine patients were carriers of the PNPLA3 p.I148M prosteatogenic [M] risk allele, eight of whom were heterozygotes. CAP values were significantly (P = .045) higher in these patients and corresponded to advanced steatosis, as compared to patients with the wild‐type genotype, who demonstrated CAP values consistent with mild steatosis (311 ± 33 dB/m. vs 254 ± 62 dB/m). CAP values did not differ significantly in carriers of distinct TM6SF2 and MBOAT7 genotypes; however, carriers of the risk alleles displayed higher CAP as compared to wild‐type patients. Conclusions This study shows that in patients with acromegaly, carriers of the PNPLA3 susceptibility allele are at risk of developing hepatic steatosis, as assessed by CAP. Comorbid NAFLD might compound prognosis in such patients; thus, further research into the pathomechanisms and treatment of NAFLD in acromegaly is warranted

    Hepatic steatosis in patients with acromegaly

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    Objective Comorbid NAFLD is increasingly being diagnosed in patients with diabetes and nondiabetic endocrinopathies. The aim of this study was to assess hepatic steatosis noninvasively by transient elastography in patients with acromegaly. Design A cross‐sectional study including 22 patients with acromegaly. Methods Hepatic steatosis was quantified using controlled attenuation parameter (CAP) during elastography. Anthropometric measurements were obtained, serum liver function tests and lipid and hormone profiles were measured, and prosteatogenic gene variants were genotyped using standard assays. Results In total, 41% of patients were women (mean age 60 ± 14.7 years, mean BMI 31.2 ± 4.6 kg/m2). Hepatic steatosis, as defined by CAP > 248 dB/m, was present in 66% of patients. Five (45%) of the patients with hepatic steatosis also had fibrosis, and one presented with cirrhosis. Nine patients were carriers of the PNPLA3 p.I148M prosteatogenic [M] risk allele, eight of whom were heterozygotes. CAP values were significantly (P = .045) higher in these patients and corresponded to advanced steatosis, as compared to patients with the wild‐type genotype, who demonstrated CAP values consistent with mild steatosis (311 ± 33 dB/m. vs 254 ± 62 dB/m). CAP values did not differ significantly in carriers of distinct TM6SF2 and MBOAT7 genotypes; however, carriers of the risk alleles displayed higher CAP as compared to wild‐type patients. Conclusions This study shows that in patients with acromegaly, carriers of the PNPLA3 susceptibility allele are at risk of developing hepatic steatosis, as assessed by CAP. Comorbid NAFLD might compound prognosis in such patients; thus, further research into the pathomechanisms and treatment of NAFLD in acromegaly is warranted
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