Asymmetric spin-wave dispersion due to Dzyaloshinskii-Moriya interaction in an ultrathin Pt/CoFeB film

Employing Brillouin spectroscopy, strong interfacial Dzyaloshinskii-Moriya interactions have been observed in an ultrathin Pt/CoFeB film. Our micromagnetic simulations show that spin-wave nonreciprocity due to asymmetric surface pinning is insignificant for the 0.8nmthick CoFeB film studied. The observed high asymmetry of the monotonic spin wave dispersion relation is thus ascribed to strong Dzyaloshinskii-Moriya interactions present at the Pt/CoFeB interface. Our findings should further enhance the significance of CoFeB as an important material for magnonic, spintronic and skyrmionic applications.Comment: 12 pages, 4 figure

Visualising urban air quality using aermod, calpuff and CFD models: A critical review

Degradation of air quality level can affect human's health especially respiratory and circulatory system. This is because the harmful particles will penetrate into human's body through exposure to surrounding. The existence of air pollution event is one of the causes for air quality to be low in affected urban area. To monitor this event, a proper management of urban air quality is required to solve and reduce the impact on human and environment. One of the ways to manage urban air quality is by modelling ambient air pollutants. So, this paper reviews three modelling tools which are AERMOD, CALPUFF and CFD in order to visualise the air pollutants in urban area. These three tools have its own capability in modelling the air quality. AERMOD is better to be used in short range dispersion model while CALPUFF is for wide range of dispersion model. Somehow, it is different for CFD model as this model can be used in wide range of application such as air ventilation in clothing and not specifically for air quality modelling only. Because of this, AERMOD and CALPUFF model can be classified in air quality modelling tools group whereas CFD modelling tool is classified into different group namely a non-specific modelling tool group which can be implemented in many fields of study. Earlier air quality researches produced results in two-dimensional (2D) visualization. But there are several of disadvantages for this technique. It cannot provide height information and exact location of pollutants in three-dimensional (3D) as perceived in real world. Moreover, it cannot show a good representation of wind movement throughout the study area. To overcome this problem, the 3D visualization needs to be implemented in the urban air quality study. Thus, this paper intended to give a better understanding on modeling tools with the visualization technique used for the result of performed research

The Influence of Adjacent Segment on the Reliability of Cu Dual Damascene Interconnects

Three terminal âdotted-I’ interconnect structures, with vias at both ends and an additional via in the middle, were tested under various test conditions. Mortalities (failures) were found in right segments with jL value as low as 1250 A/cm, and the mortality of a dotted-I segment is dependent on the direction and magnitude of the current in the adjacent segment. Some mortalities were also found in the right segments under a test condition where no failure was expected. Cu extrusion along the delaminated Cu/Si₃N₄ interface near the central via region was believed to cause the unexpected failures. From the time-to-failure (TTF), it is possible to quantify the Cu/Si₃N₄ interfacial strength and bonding energy. Hence, the demonstrated test methodology can be used to investigate the integrity of the Cu dual damascene processes. As conventionally determined critical jL values in two-terminal via-terminated lines cannot be directly applied to interconnects with branched segments, this also serves as a good methodology to identify the critical effective jL values for immortality.Singapore-MIT Alliance (SMA

A review on measuring entrepreneurs' social behaviour via spatial analysis techniques

This article reviews the subject of entrepreneur with a focus on the components of the entrepreneurial personality traits that are reflected in entrepreneur behaviour. Human behaviour receives a warm welcome in social psychology for examination and measurement of individual social behaviour. There are a number of tools to measure human behaviour in social science such as Likert scale, Indices, Social Network Analysis, E-scan and lastly most popular Big Five Factor Model. In entrepreneurship, entrepreneur's personality can be reflected in their action, activity, and behaviour in certain space such as traveling to find raw resources in certain distance or their decision on size of the shop. Using in-depth observation and examination of this behaviour, there are several spatial elements that could lead to the possibility in implementing spatial measurement in entrepreneur behaviour. However, there is a scarcity of research and implementation of the spatial measurement on entrepreneur behaviour, even though it is already acknowledged that space influences human behaviour and vice versa human behaviour has an impact on space. Thus, this article aims to highlight the possibility of implementing spatial measurement in entrepreneur behaviour and current exploration of spatial measurement for human behaviours

Towards 3D smart campus via 3D city modelling

The smart city concept may aid in improving the city management, enhance the efficiency and thus increase the effectiveness of the city, where it is mainly focused on both information and technologies. This concept appears to be applicable for a smaller area such as university campus. Based on this idea, this research tries to implement the 3D smart campus for Universiti Teknologi Malaysia (UTM). This is an initial research towards a real implementation of 3D smart campus and conceivably 3D smart cities. This research focuses on the development of UTM smart campus by using 3D city modelling. The QGIS software was used to develop the 3D models. Then, the 3D model is viewed in a web browser for better 3D visualization and navigation. Furthermore, the results show that the 3D developed models for UTM smart campus can be a reliable platform to manage the spatial query and viewing the attributes of UTM campus buildings and facilities. This can be seen beneficial to the physical future development of the UTM campus area

Interethnic differences in neuroimaging markers and cognition in Asians, a population-based study

We examined interethnic differences in the prevalence of neuroimaging markers of cerebrovascular and neurodegenerative disease in 3 major Asian ethnicities (Chinese, Malays, and Indians), as well as their role in cognitive impairment. 3T MRI brain scans were acquired from 792 subjects (mean age: 70.0 ± 6.5years, 52.1% women) in the multi-ethnic Epidemiology of Dementia In Singapore study. Markers of cerebrovascular disease and neurodegeneration were identified. Cognitive performance was evaluated using Mini Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and a neuropsychological assessment. Compared to Chinese, Malays had a higher burden of intracranial stenosis (OR: 2.28. 95%CI: 1.23-4.20) and cortical atrophy (β: -0.60. 95%CI: -0.78, -0.41), while Indians had a higher burden of subcortical atrophy (β: -0.23. 95%CI: -0.40, -0.06). Moreover, Malay and Indian ethnicities were likely to be cognitively impaired (OR for Malays: 3.79. 95%CI: 2.29-6.26; OR for Indians: 2.87. 95%CI: 1.74-4.74) and showed worse performance in global cognition (β for Malays: -0.51. 95%CI: -0.66, -0.37; and Indians: -0.32. 95%CI: -0.47, -0.17). A higher burden of cerebrovascular and neurodegenerative markers were found in Malays and Indians when compared to Chinese. Further research is required to fully elucidate the factors and pathways that contribute to these observed differences

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis

Psoriasis is an immune-mediated skin disorder associated with severe systemic comorbidities. Whereas IL-36 is a key disease driver, the pathogenic role of this cytokine has mainly been investigated in skin. Thus, its effects on systemic immunity and extracutaneous disease manifestations remain poorly understood. To address this issue, we investigated the consequences of excessive IL-36 activity in circulating immune cells. We initially focused our attention on generalized pustular psoriasis (GPP), a clinical variant associated with pervasive upregulation of IL-36 signaling. By undertaking blood and neutrophil RNA sequencing, we demonstrated that affected individuals display a prominent IFN-I signature, which correlates with abnormal IL-36 activity. We then validated the association between IL-36 deregulation and IFN-I over-expression in patients with severe psoriasis vulgaris (PV). We also found that the activation of IFN-I genes was associated with extracutaneous morbidity, in both GPP and PV. Finally, we undertook mechanistic experiments, demonstrating that IL-36 acts directly on plasmacytoid dendritic cells, where it potentiates toll-like receptor (TLR)-9 activation and IFN-α production. This effect was mediated by the upregulation of PLSCR1, a phospholipid scramblase mediating endosomal TLR-9 translocation. These findings identify an IL-36/ IFN-I axis contributing to extracutaneous inflammation in psoriasis.</p

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre-specified patient subgroups in the Effisayil 1 study

Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with a generalized pustular psoriasis (GPP) flare. Previously published data from this study revealed that within 1 week, rapid pustular and skin clearance were observed in patients receiving spesolimab versus placebo. In this pre‐specified subgroup analysis, the efficacy of spesolimab was evaluated according to patient demographic and clinical characteristics at baseline in patients receiving spesolimab (n = 35) or placebo (n = 18) on Day 1. Efficacy was by assessed by achievement of primary endpoint (Generalized Pustular Psoriasis Physician Global Assessment [GPPGA] pustulation subscore of 0 at Week 1) and key secondary endpoint (GPPGA total score of 0 or 1 at Week 1). Safety was assessed at Week 1. Spesolimab was found to be efficacious and had a consistent and favourable safety profile in patients presenting with a GPP flare, regardless of patient demographics and clinical characteristics at baseline

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design

A