Calcium-permeable channels activated via guanine nucleotide-dependent mechanism in human carcinoma cells

AbstractPatch clamp experiments on human carcinoma A431 cells have revealed two types of Ca2+-permeable channels, the activity of which can be increased by the application of non-hydrolyzable analogues of GTP to the intracellular side of the membrane. With 105 mM Ca2+ in recording pipette at 30–33°C their unitary conductances (in pS) are 1.3 (SG-channels) and 2.4 (G-channels). G- and, possibly, SG-channels are activated from the extracellular side of the membrane with epidermal growth factor (EGF). The data are consistent with the hypothesis that both channels are activated via guanine nucleotide binding (G) proteins

Library and information resources and users of digital resources in the humanities

Purpose – The purpose of this article is to discuss the results of the Log Analysis of Internet Resources in the Arts and Humanities (LAIRAH) study. It aims to concentrate upon the use and importance of information resources, physical research centres and digital finding aids in scholarly research. Design/methodology/approach – Results are presented of web server log analysis of portals for humanities scholars: the arts and humanities data service (AHDS) website and Humbul Humanities Hub. These are used to determine which resources were accessed most often, or seldom. Questionnaire data about perceptions of digital resource use were also gathered. Findings – Information resources such as libraries, archives museums and research centres, and the web pages that provide information about them are vital for humanities scholars. The university library website was considered to be the most important resource, even compared to Google. Secondary finding aids and reference resources are considered more important than primary research resources, especially those produced by other scholars, whose output is less trusted than publications produced by commercial organisations, libraries, archives and museums. Practical implications – Digital resources have not replaced physical information resources and the people who staff them, thus both types of information continue to require funding. Scholars trust the judgment of information professionals, who therefore need to be trained to evaluate and recommend specialist digital research resources. Originality/value – LAIRAH was the first research project to use quantitative data to investigate resource use. Findings about the type of resources used are based on evidence rather than opinions alone. This gives a clearer picture of usage that may be used to plan future information services

Systemic approach to business administration of innovation-oriented enterprise

The authors use the method of regression analysis, with the help of which they determine the dependence of the level and rates of economic growth of modern economic systems on development of innovation-oriented entrepreneurship. The additional methodological instrumentarium includes the proprietary method of evaluation of effectiveness of business administration of innovation-oriented enterprise. The authors offer a systemic approach to business administration of innovation-oriented enterprise and prove its high effectiveness as compared to the usual approach by the example of modern Russian innovation-oriented enterprises.peer-reviewe

Eocene–early Oligocene climate and vegetation change in southern China: Evidence from the Maoming Basin

Although the Eocene-Oligocene climate transition marks a critical point in the development of the ‘icehouse’ global climate of the present little is known about this important change in the terrestrial realm at low latitudes. Our palynological study of the Shangcun Formation shows it to be early Oligocene in age: palyno-assemblages in the lower part of the formation indicate a cool interval dominated by conifer pollen in the earliest Oligocene followed by a warmer regime in the second half of the early Oligocene. To quantify middle Eocene to late early Oligocene climate conditions at low (~ 20°N) palaeolatitudes in southern Asia several thousand leaf fossil specimens from the Maoming Basin, southern China, were subjected to a multivariate (CLAMP) analysis of leaf form. For terrestrial palaeoclimate comparisons to be valid the palaeoaltitude at which the proxy data are obtained must be known. We find that leaves preserved in the Youganwo (middle Eocene), Huangniuling (late Eocene) and Shangcun (early Oligocene) formations were likely to have been deposited well above sea level at different palaeoelevations. In the Youganwo Formation fine-grained sediments were deposited at an altitude of ~ 1.5 km, after which the basin dropped to ~ 0.5 km by the time the upper Huangniuling sediments were deposited. The basin floor then rose again by 0.5 km reaching an altitude of approximately 1 km in which the Shangcun Formation fine-grained sediments were accumulated. Within the context of these elevation changes the prevailing climates experienced by the Youganwo, Lower Huangniuling, Upper Huangniuling and Shangcun fossil floras were humid subtropical with hot summers and warm winters, but witnessed a progressive increase in rainfall seasonality. By the early Oligocene rainfall seasonality was similar to that of the modern monsoonal climate of Guangdong Province, southern China. All floras show leaf physiognomic spectra most similar to those growing under the influence of the modern Indonesia-Australia Monsoon, but with no evidence of any adaptation to today's South or East Asia Monsoon regimes. The Upper Huangniuling Flora, rich in dipterocarp plant megafossils, grew in the warmest conditions with the highest cold month mean temperature and at the lowest altitude

Effects and Risks of Digital Quality of Life in Russian Regions

Widespread digital transformation significantly changed people’s quality of life. We hypothesise that the digital component of people’s quality of life had a positive but differential impact on economic growth in Russian regions during 2015–2019. Moreover, economic and institutional risks occurring at the current stage of digital transformation could negatively affect economic development. The research pays special attention to the institutional factor, namely, project management quality and its influence on real gross domestic product (GDP) per capita in Russian regions. Methods of economic research were used such as index, rating, expert evaluation methods as well as regression and panel data models (including those with dummy variables). Transformation assessment was based on an integral index proposed by the authors called the Russian regional index of digital component of people’s quality of life (RRIDCPQL). The value of this digital index was increasing during 2015–2019. The hypotheses of statistically significant influence of the digital quality of life, regional and temporal unobserved factors on real GDP per capita in 2015–2019 were confirmed. However, the study rejected the hypotheses of the positive impact of digitalisation on the unemployment rate and on the decrease in the share of government employees. Positive influence of digitalisation on the divorce rate was revealed while its negative influence on economic criminality and real income per capita of the population was partially confirmed. The importance of project management quality of the program “Digital economy of the Russian Federation” for regional development was demonstrated. The research results presenting new data on the growth of digital economy can be used to adjust the implementation of digital projects in Russian regions

Effects and Risks of Digital Quality of Life in Russian Regions

Widespread digital transformation significantly changed people’s quality of life. We hypothesise that the digital component of people’s quality of life had a positive but differential impact on economic growth in Russian regions during 2015–2019. Moreover, economic and institutional risks occurring at the current stage of digital transformation could negatively affect economic development. The research pays special attention to the institutional factor, namely, project management quality and its influence on real gross domestic product (GDP) per capita in Russian regions. Methods of economic research were used such as index, rating, expert evaluation methods as well as regression and panel data models (including those with dummy variables). Transformation assessment was based on an integral index proposed by the authors called the Russian regional index of digital component of people’s quality of life (RRIDCPQL). The value of this digital index was increasing during 2015–2019. The hypotheses of statistically significant influence of the digital quality of life, regional and temporal unobserved factors on real GDP per capita in 2015–2019 were confirmed. However, the study rejected the hypotheses of the positive impact of digitalisation on the unemployment rate and on the decrease in the share of government employees. Positive influence of digitalisation on the divorce rate was revealed while its negative influence on economic criminality and real income per capita of the population was partially confirmed. The importance of project management quality of the program “Digital economy of the Russian Federation” for regional development was demonstrated. The research results presenting new data on the growth of digital economy can be used to adjust the implementation of digital projects in Russian regions