Evaluating the flow stress of electrical steel under cold rolling in terms of the strain-rate hardening effect

The flow stress of the Fe+3%Si electrical steel under actual cold rolling conditions is evaluated on the basis of the approximation of the existing data on the work hardening and strain-rate hardening of this steel during cold tensile testing. It has been discovered that ductility is significant during electrical steel cold rolling and, besides, that its value is lower for large strains and strain rates than for low strains and strain rates. © 2016 Author(s)

The impact of investment climate and financial analysis implications in making investment decisions

У статті відображено необхідні відповідні умови для виробництва та реалізації конкурентоспроможної товарної продукції, за яких вітчизняні підприємства здатні ефективно розвиватися. У статті розкрито економічну сутність управління фінансами підприємства та процесів фінансово-господарської діяльності, які дозволяють виявити динаміку основних параметрів виробництва та реалізації продукції, її постачання, кількісно оцінити вплив зовнішніх та внутрішніх чинників на зміну протягом певного періоду, визначити причини зміни і обґрунтувати тенденції розвитку підприємства, а також визначити напрями та шляхи розвитку підприємства. Розкрито сутність інвестицій, інвестиційної діяльності, інвестиційної привабливості та визначено чинники, які впливають на стабільність економічного розвитку підприємств та активізацію їх інвестиційної діяльності. Розкрита сутність інвестиційного клімату і чинників, які формують інвестиційний клімат країни. Здійснено аналіз інвестиційної привабливості підприємств, виявлені чинники які впливають на альтернативні інвестиційні проекти. У статті на основі дослідження здійснено узагальнену класифікацію рішень щодо інвестиційних проектів, виявлено критерії, які сприяють прийняттю інвестиційних рішень. Розглянуто сутність фінансового аналізу як елементу системи антикризового управління інвестиційними ресурсами, що дозволяє визначити тенденції розвитку підприємства, виявити причини зміни і обґрунтувати розвиток підприємства на перспективу. У статті надано рекомендації щодо прийняття інвестиційних рішень.В статье отражены необходимые соответствующие условия для производства и реализации конкурентоспособной товарной продукции, при которых отечественные предприятия способны эффективно развиваться. В статье раскрыта экономическая сущность управления финансами предприятия и процессов финансово-хозяйственной деятельности, которые позволяют выявить динамику основных параметров производства и реализации продукции, ее поставки, количественно оценить влияние внешних и внутренних факторов на изменение в течение определенного периода, выявить причины изменения и обосновать тенденции развития предприятия, а также определить направления и пути развития предприятия. Раскрыта сущность инвестиций, инвестиционной деятельности, инвестиционной привлекательности и исследованы факторы, которые влияют на стабильность экономического развития предприятий и активизации их инвестиционной деятельности. Раскрыта сущность инвестиционного климата и факторов, которые формируют инвестиционный климат страны. Проведен анализ инвестиционной привлекательности предприятий, выявлены факторы, влияющие на альтернативные инвестиционные проекты. В статье на основе исследования дана обобщенная классификация решений по инвестиционным проектам и названы критерии, способствующие принятию инвестиционных решений. Раскрыта сущность финансового анализа как элемента системы антикризисного управления инвестиционными ресурсами, позволяющего определить тенденции развития предприятия, выявить причины изменения и обосновать перспективы развития предприятия. В статье даны рекомендации по принятию инвестиционных решений.The paper attempts to expose the most favourable conditions for domestic enterprises to be to competitive in manufacturing and selling of competitive goods and products and thus have prospects for further effective development. The study provides insights into the economic nature of enterprise financial management basics as well as explores the processes of financial and economic activities to reveal the key indicators dynamics for production and sales, product supply patterns, to measure the effects from external and internal factors of change over a certain period, to identify the reasons for change and justify the enterprise development trends, together with building pathways to boost the enterprise performance. A thorough study on the roots of investment, investment activity, investment attractiveness and the factors that affect the stability of enterprise business development and investment activity enhancement have been conducted. The findings also present the results of an in-depth study on the investment climate specifics and impact factors that shape the investment climate in Ukraine. The analysis of investment attractiveness of the national businesses and the factors affecting alternative investment projects have been performed. Based on the research results, the paper offers a generalized investment solutions framework as well as suggests the criteria that facilitate effective investment decision making. In this study, financial analysis is viewed as a critical element within the overall crisis management system to ensure investment efficiency and identify enterprise development trends as well as the reasons for change and to be able to justify the enterprise further development prospects. The conclusions provide recommendations for making effective investment decisions

Discovery of the neutron radiative decay

The aim of this work is experimental discovery and research of a rare neutron mode, the radiative beta-decay, where a new particle, the radiative gamma-quantum, is formed along with the expected decay products beta-electron, recoil proton and antineutrino. The discovery of this rare neutron decay mode was conducted through identification of triple coincidences events: simultaneous registration of beta electron, proton and radiative gamma-quantum. The ordinary neutron decay was registered by double coincidences of beta electron and recoil proton. The ratio of triple to double coincidences is connected with relative intensity of radiative neutron decay (branching ratio - B.R.) B.R. = (3.2+1.6)10-3 (with 90 % C.L. and in the gamma energy region greater than 35 keV), which we are the first in the world to measure during the second and third cycles on FRMII (TUM, Germany) in Summer 2005. This value of B.R. is consistent with standard electroweak theory.Comment: Corrected version of this paper was published in JETP Letters 83(1

The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density

This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ Springer-Verlag 2008.In the nuclei of human lymphocytes, chromosome territories are distributed according to the average gene density of each chromosome. However, chromosomes are very heterogeneous in size and base composition, and can contain both very gene-dense and very gene-poor regions. Thus, a precise analysis of chromosome organisation in the nuclei should consider also the distribution of DNA belonging to the chromosomal bands in each chromosome. To improve our understanding of the chromatin organisation, we localised chromosome 7 DNA regions, endowed with different gene densities, in the nuclei of human lymphocytes. Our results showed that this chromosome in cell nuclei is arranged radially with the gene-dense/GC-richest regions exposed towards the nuclear interior and the gene-poorest/GC-poorest ones located at the nuclear periphery. Moreover, we found that chromatin fibres from the 7p22.3 and the 7q22.1 bands are not confined to the territory of the bulk of this chromosome, protruding towards the inner part of the nucleus. Overall, our work demonstrates the radial arrangement of the territory of chromosome 7 in the lymphocyte nucleus and confirms that human genes occupy specific radial positions, presumably to enhance intra- and inter-chromosomal interaction among loci displaying a similar expression pattern, and/or similar replication timing

Integrating transposable elements in the 3D genome

Chromosome organisation is increasingly recognised as an essential component of genome regulation, cell fate and cell health. Within the realm of transposable elements (TEs) however, the spatial information of how genomes are folded is still only rarely integrated in experimental studies or accounted for in modelling. Whilst polymer physics is recognised as an important tool to understand the mechanisms of genome folding, in this commentary we discuss its potential applicability to aspects of TE biology. Based on recent works on the relationship between genome organisation and TE integration, we argue that existing polymer models may be extended to create a predictive framework for the study of TE integration patterns. We suggest that these models may offer orthogonal and generic insights into the integration profiles (or "topography") of TEs across organisms. In addition, we provide simple polymer physics arguments and preliminary molecular dynamics simulations of TEs inserting into heterogeneously flexible polymers. By considering this simple model, we show how polymer folding and local flexibility may generically affect TE integration patterns. The preliminary discussion reported in this commentary is aimed to lay the foundations for a large-scale analysis of TE integration dynamics and topography as a function of the three-dimensional host genome

Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization

This work was supported in part by a Marie Curie CIG grant (PCIG14-GA-2013-631011 CSKFingerprints) and a BBSRC grant (BB/P006108/1). MCK is supported by a PhD studentship from the Life Sciences Initiative at QMUL

Binomial Mitotic Segregation of MYCN-Carrying Double Minutes in Neuroblastoma Illustrates the Role of Randomness in Oncogene Amplification

BACKGROUND: Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development. PRINCIPAL FINDINGS: We show that MYCN-carrying DMs in NB cells translocate from the nuclear interior to the periphery of the condensing chromatin at transition from interphase to prophase and are preferentially located adjacent to the telomere repeat sequences of the chromosomes throughout cell division. However, DM segregation was not affected by disruption of the telosome nucleoprotein complex and DMs readily migrated from human to murine chromatin in human/mouse cell hybrids, indicating that they do not bind to specific positional elements in human chromosomes. Scoring DM copy-numbers in ana/telophase cells revealed that DM segregation could be closely approximated by a binomial random distribution. Colony-forming assay demonstrated a strong growth-advantage for NB cells with high DM (MYCN) copy-numbers, compared to NB cells with lower copy-numbers. In fact, the overall distribution of DMs in growing NB cell populations could be readily reproduced by a mathematical model assuming binomial segregation at cell division combined with a proliferative advantage for cells with high DM copy-numbers. CONCLUSION: Binomial segregation at cell division explains the high degree of MYCN copy-number variability in NB. Our findings also provide a proof-of-principle for oncogene amplification through creation of genetic diversity by random events followed by Darwinian selection