Crystal and Molecular Docking Studies of 3-[ Bis-(2-Hydroxy-4,4-Dimethyl-6-Oxo-Cyclohex-1-Enyl)-Methyl]Benzonitrilewith Focal Adhesion Kinase Inhibitors

In the present study crystal structure of 3-[Bis-(2-hydroxy-4,4-dimethyl-6-oxo-cyclohex-1-enyl)-methyl]benzonitrile was determined using single crystal X-ray diffraction. Further the structural features was extrapolated to molecular docking studies with focal adhesion kinase (FAK) domain using Autodock to study its anticancerous property. The compound exhibited considerable bacterial inhibition of lower to moderate concentrations. We conclude that these derivatives can be used in medicine and have enormous potential as pharmaceutical agents due to their biological activities. The above titled receptor gain functional and structural insights into their mechanism of inhibition and explore its potential as an anticancer agent

Crystal and molecular docking studies of 3-​[Bis-​(2-​hydroxy-​4,​4-​dimethyl-​6-​oxo-​cyclohex-​1-​enyl)​-​methyl]​benzonitrile with focal adhesion kinase inhibitors

In the present study crystal structure of 3-​[Bis-​(2-​hydroxy-​4,​4-​dimethyl-​6-​oxo-​cyclohex-​1-​enyl)​-​methyl]​benzonitrile was detd. using single crystal X-​ray diffraction. Further the structural features was extrapolated to mol. docking studies with focal adhesion kinase (FAK) domain using Autodock to study its anticancerous property. The compd. exhibited considerable bacterial inhibition of lower to moderate concns. We conclude that these derivs. can be used in medicine and have enormous potential as pharmaceutical agents due to their biol. activities. The above titled receptor gain functional and structural insights into their mechanism of inhibition and explore its potential as an anticancer agent

Sonographic Evaluation of Lower Extremity Interosseous Membrane Injuries

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135663/1/jum200322121369.pd

Effects of nitrogen, plant density, moisture stress and artificial inoculation with macrophomina phaseohna on charcoal rot incidence in grain sorghum

Effects of different levels of nitrogen, plant density, soil moisture stress and of anificial inoculation with Macrophomina phaseolina on charcoal rot incidence in grain sorghum were studied in a split-split-split field plot design. Nitrogen levels were applied to main plots; plant densities, moisture stresses and inoculations were replicated in sub, sub-sub and sub-sub-sub plots. A gradient of soil moisture stress was created during grain filling by line-source sprinkler irrigation. Analysis of variance indicated significant effects of moisture stress, plant density and their interactions on charcoal rot disease incidence as measured by piant lodging. Lodging increased linearly along the gradient of water supply suggesting a positive relationship between moisture stress and disease development. Lodging was also significantly (P < 0.01) and highly correlated with other charcoal rot disease parameters (soft stalk, number of nodes crossed, root infection and plant senescence). There were no significant differences (P < 0.05) in charcoal rot incidence among inoculation treatments. Lodging increased in both high nitrogen and high plant population treatments under moisture stress condition

Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials

An amendment to this paper has been published and can be accessed via the original article

Users’ opinion towards resources and services of corporate libraries: A case study of HCL technologies information centre, Bangalore

The main purpose of this paper is to explore the users opinion towards HCL technology, Bangalore library resources and services. A structured questionnaire was personally distributed among 100 HCL library users by using convenient random sampling, out of that 60 filled questionnaire were returned accounting 60%. The study reveals that majority45(75%) of respondents are male, about 20(33.33%) respondents are belongs to more than 40 years of age, Users are satisfied with the services offered by the information center accounting 246(37.27%) respondents opine agree and nearly 216(32.72%) respondents state strongly agree. Majority of users 288(95.99%) are fully satisfied with the quality of library staff who render library services. And users are not satisfied with collection of CD/DVD, reference books and they are also not satisfied with the printer and scanner facility provided in the library

Effect of structural changes in proteins derived from gata4 nonsynonymous single nucleotide polymorphisms in congenital heart disease

Congenital heart disease is the most common type of birth defect. The single nucleotide polymorphism in GATA4 is associated with various congenital heart disease phenotypes. In the present study, we analysed the nonsynonymous single nucleotide polymorphism of GATA4, which are involved in congenital heart disease by predicting the changes in protein structures. Total of 49 nonsynonymous single nucleotide polymorphisms of GATA4 was screened from congenital heart disease patients of Mysore and also globally reported nonsynonymous single nucleotide polymorphisms. To understand the role of nonsynonymous single nucleotide polymorphisms, we mutated the sequence and translated into amino acids. Further the mutated protein secondary structure is predicted and tertiary structure is predicted using homology modeling. The quantitative evaluation of protein structure quality was verified with Volume Area Dihedral Angle Reporter server. Results revealed the secondary, tertiary structural changes along with changes in free energy of folding, volume and accessible surface area. Thus, the structural changes in the mutated proteins impaired the normal function of GATA4

MHD Heat and Mass Transfer Flow of a Viscoelastic Fluid Past an Impulsively Started Infinite Vertical Plate with Chemical reaction

ABSTRACT: The objective of the present study, we discuss the heat and mass transfer on MHD unsteady visco-elastic second order Rivlin-Erickson fluid past an impulsively started infinite vertical plate in the presence of a foreign mass and constant mass flux on taking into account of viscous dissipative heat at the plate under the influence of a uniform transverse magnetic field in the presence of chemical reaction. The flow is governed by a coupled non-linear system of partial differential equations. These equations are solved by using perturbation technique. The velocity, temperature, concentration, skin -friction and the rate of heat transfer are derived. The results are graphically discussed for various values of physical parameters