984 research outputs found
Lp-cohomology of negatively curved manifolds
We compute the -cohomology spaces of some negatively curved manifolds.
We deal with two cases: manifolds with finite volume and sufficiently pinched
negative curvature, and conformally compact manifolds
The critical Ising lines of the d=2 Ashkin-Teller model
The universal critical point ratio is exploited to determine positions of
the critical Ising transition lines on the phase diagram of the Ashkin-Teller
(AT) model on the square lattice. A leading-order expansion of the ratio in
the presence of a non-vanishing thermal field is found from finite-size scaling
and the corresponding expression is fitted to the accurate perturbative
transfer-matrix data calculations for the square clusters with
.Comment: RevTex, 4 pages, two figure
A user-friendly and accurate machine learning tool for the evaluation of the worldwide yearly photovoltaic electricity production
While traditional methods for modelling the thermal and electrical behaviour of photovoltaic (PV) modules rely on analytical and empirical techniques, machine learning is gaining interest as a way to reduce the time, expertise, and tools required by designers or experts while maintaining high accuracy and reliability. This research presents a data-driven machine learning tool based on artificial neural networks (ANNs) that can forecast yearly PV electricity directly at the optimal PV inclination angle without geographic restrictions and is valid for a wide range of electrical characteristics of PV modules. Additionally, empirical correlations were developed to easily determine the optimal PV inclination angle worldwide. The ANN algorithm, developed in Matlab, systematically and quantitatively summarizes the behaviour of eight PV modules in 48 worldwide climatic conditions. The algorithm's applicability and robustness were proven by considering two different PV modules in the same 48 locations. Yearly climatic variables and electrical/thermal PV module parameters serve as input training data. The yearly PV electricity is derived using dynamic simulations in the TRNSYS environment, which is a simulation program primarily and extensively used in the fields of renewable energy engineering and building simulation for passive as well as active solar design. Multiple performance metrics validate that the ANN-based machine learning tool demonstrates high reliability and accuracy in the PV energy production forecasting for all weather conditions and PV module characteristics. In particular, by using 20 neurons, the highest value of R-square of 0.9797 and the lowest values of the root mean square error and coefficient of variance of 14.67 kWh and 3.8%, respectively, were obtained in the training phase. This high accuracy was confirmed in the ANN validation phase considering other PV modules. An R-square of 0.9218 and values of the root mean square error and coefficient of variance of 31.95 kWh and 7.8%, respectively, were obtained. The results demonstrate the algorithm's vast potential to enhance the worldwide diffusion and economic growth of solar energy, aligned with the seventh sustainable development goal
A phase I clinical and pharmacological study evaluating vinflunine in combination with doxorubicin as first line treatment in metastatic breast cancer
Vinfunine (VFL) is a novel bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer. We conducted a phase I study combining VFL with doxorubicin (DXR) to define the recommended dose (RD), safety, pharmacokinetic (PK) interaction and efficacy. Two schedules (day 1 every 3weeks; days 1 and 8 every 3weeks) were investigated as first line chemotherapy in metastatic breast cancer patients. Thirty-two patients received a total of 162 cycles of the VFL-DXR combination (median 6). The RDs were VFL 250mg/m2/DXR 40mg/m2 every 3weeks for schedule 1 and VFL 120mg/m2/DXR 25mg/m2 days 1 and 8 every 3weeks for schedule 2. The main dose-limiting toxicity was neutropenia. The most frequent non-hematological adverse events were nausea, fatigue, constipation, vomiting, anorexia, stomatitis and dyspnea. Objective response rate was reached in 47.1% of the patients. No PK interaction was observed. VFL-DXR combination is feasible with manageable toxicity. The antitumor activity was promising and supports further evaluatio
Fermions and Disorder in Ising and Related Models in Two Dimensions
The aspects of phase transitions in the two-dimensional Ising models modified
by quenched and annealed site disorder are discussed in the framework of
fermionic approach based on the reformulation of the problem in terms of
integrals with anticommuting Grassmann variables.Comment: 11 pages, 1 table, no figures. The discussion is merely based on a
talk given at the International Bogoliubov Conference on Problems of
Theoretical and Mathematical Physics, MIRAS--JINR, Moscow--Dubna, Russia,
August 21--27, 200
Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase
Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs. leukemia effect and graft vs. host disease could be separated. We here identified four new HLA class II-restricted minor histocompatibility antigens using whole genome association scanning. For one of the new antigens, i.e., LB-PIP4K2A-1S, we measured strong T-cell recognition of the donor variant PIP4K2A-1N when pulsed as exogenous peptide, while the endogenously expressed variant in donor EBV-B cells was not recognized. We showed that lack of T-cell recognition was caused by intracellular cleavage by a protease named asparagine endopeptidase (AEP). Furthermore, microarray gene expression analysis showed that PIP4K2A and AEP are both ubiquitously expressed in a wide variety of healthy tissues, but that expression levels of AEP were lower in primary acute myeloid leukemia (AML). In line with that, we confirmed low activity of AEP in AML cells and demonstrated that HLA-DRB1*03:01 positive primary AML expressing LB-PIP4K2A-1S or its donor variant PIP4K2A-1N were both recognized by specific T-cells. In conclusion, LB-PIP4K2A-1S not only represents a novel minor histocompatibility antigen but also provides evidence that donor T-cells after allogeneic stem cell transplantation can target the autologous allelic variant as leukemia-associated antigen. Furthermore, it demonstrates that endopeptidases can play a role in cell type-specific intracellular processing and presentation of HLA class II-restricted antigens, which may be explored in future immunotherapy of AML
Elliptic operators on manifolds with singularities and K-homology
It is well known that elliptic operators on a smooth compact manifold are
classified by K-homology. We prove that a similar classification is also valid
for manifolds with simplest singularities: isolated conical points and fibered
boundary. The main ingredients of the proof of these results are: an analog of
the Atiyah-Singer difference construction in the noncommutative case and an
analog of Poincare isomorphism in K-theory for our singular manifolds.
As applications we give a formula in topological terms for the obstruction to
Fredholm problems on manifolds with singularities and a formula for K-groups of
algebras of pseudodifferential operators.Comment: revised version; 25 pages; section with applications expande
On "many black hole" space-times
We analyze the horizon structure of families of space times obtained by
evolving initial data sets containing apparent horizons with several connected
components. We show that under certain smallness conditions the outermost
apparent horizons will also have several connected components. We further show
that, again under a smallness condition, the maximal globally hyperbolic
development of the many black hole initial data constructed by Chrusciel and
Delay, or of hyperboloidal data of Isenberg, Mazzeo and Pollack, will have an
event horizon, the intersection of which with the initial data hypersurface is
not connected. This justifies the "many black hole" character of those
space-times.Comment: several graphic file
The critical amplitude ratio of the susceptibility in the random-site two-dimensional Ising model
We present a new way of probing the universality class of the site-diluted
two-dimensional Ising model. We analyse Monte Carlo data for the magnetic
susceptibility, introducing a new fitting procedure in the critical region
applicable even for a single sample with quenched disorder. This gives us the
possibility to fit simultaneously the critical exponent, the critical amplitude
and the sample dependent pseudo-critical temperature. The critical amplitude
ratio of the magnetic susceptibility is seen to be independent of the
concentration of the empty sites for all investigated values of . At the same time the average effective exponent is found
to vary with the concentration , which may be argued to be due to
logarithmic corrections to the power law of the pure system. This corrections
are canceled in the susceptibility amplitude ratio as predicted by theory. The
central charge of the corresponding field theory was computed and compared well
with the theoretical predictions.Comment: 6 pages, 4 figure
Holographic Uniformization
We derive and study supergravity BPS flow equations for M5 or D3 branes
wrapping a Riemann surface. They take the form of novel geometric flows
intrinsically defined on the surface. Their dual field-theoretic interpretation
suggests the existence of solutions interpolating between an arbitrary metric
in the UV and the constant-curvature metric in the IR. We confirm this
conjecture with a rigorous global existence proof.Comment: 52 pages, 3 figure
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